Bacterial protease alleviate chronic liver fibrosis induced by thioacetamide through suppression of hepatic stellate cells consequently decrease its proliferative index

Salem, Gad Elsayed Mohamed; Azzam, Shaimaa M; Nasser, Mona A F; Malah, Tamer El; El-Latief, Hanan M Abd; Chavanich, Suchana; Khan, Rizwan Hasan; Anwar, Hend Mohamed

doi:10.1016/j.ijbiomac.2023.124243

Cited by 1 publication

(1 citation statement)

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“…In the study of Kazzi et al, the probiotics were Bacillus . It was reported in the study of Salem et al that the released exopolysaccharide by Bacillus alleviated CCl 4 -induced liver injury in mice by lowering the activities of AST levels [ 45 ]. In the study of Crommen and Sherf-Dagan et al, the bacterium types included Lactobacillus and Bifidobacterium .…”

Section: Discussionmentioning

confidence: 99%

Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

Wang,

Zheng,

Kuang

et al. 2023

Int J Obes

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Background Probiotics are commonly used after bariatric surgery. However, uncertainty remains regarding their effects. The purpose of this systematic review was to assess the effect of probiotics in patients with morbid obesity undergoing bariatric surgery. Methods PubMed, Cochrane Library, Embase, Science Direct, and Web of Science were searched from inception to April 4, 2023. No language restrictions were applied. Relevant randomized controlled trials and controlled clinical trials were included. We used the aggregated data extracted from the trials and assessed the heterogeneity. When severe heterogeneity was detected, a random effect model was used. All stages of the review were done by independent authors. Results We screened 2024 references and included 11 randomized controlled trials and controlled clinical trials. Compared with the protocol groups, probiotics showed significant effects on regulating aspartate amino transferase level (MD = −4.32 U/L; 95% CI [−7.10, −1.53], p = 0.002), triglycerides (MD = −20.16 mg/dL; 95% CI [−34.51, −5.82], p = 0.006), weight (MD = −1.99 kg; 95% CI [−3.97, −0.01], p = 0.05), vitamin B12 (MD = 2.24 pg/dL; 95% CI [−0.02, 4.51], p = 0.05), dietary energy (MD = −151.03 kcal; 95% CI [−215.68, −86.37], p < 0.00001), dietary protein (MD = −4.48 g/day, 95% CI [−8.76, −0.20], p = 0.04), dietary carbohydrate (MD = −34.25 g/day, 95% CI [−44.87, −23.62], p < 0.00001), and dietary fiber (MD = −2.17 g/day, 95% CI [−3.21, −1.14], p < 0.0001). There were no severe side effects related to probiotics. Conclusions Our meta-analysis suggested that probiotics may delay the progression of liver function injury, improve lipid metabolism, reduce weight, and reduce food intake, although the effects on other indicators were insignificant. Probiotics may be helpful for patients undergoing bariatric surgery. The review was registered on PROSPERO (International prospective register of systematic reviews): CRD42023407970. No primary source of funding.

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Section: Discussionmentioning

confidence: 99%