Bacterial profiles and risk factors for neonatal sepsis in a rural tertiary care hospital in north India

Abstract

Objectives: To study, the bacterial profile in cases of neonatal sepsis admitted to the neonatal nursery or neonatal intensive care unit (NICU) and to identify the risk factors for early-onset neonatal sepsis. Design: Retrospective survey of hospital records from January 2012 to December 2012. Setting: A neonatal unit of a rural medical college hospital. Subjects: All inborn and outborn neonates who either had clinical signs of sepsis or were born to mothers with risk factors for sepsis and underwent a sepsis screen. Neonatal sepsis was defined as positive blood culture in babies younger than 1 month of age who had clinical signs of sepsis or had maternal risk factors for sepsis. Results: 396 neonates were screened for sepsis during the study period, of which 64 (16%) were culture positive. Of these, 42 (65.6%) had early-onset sepsis while 22 (34.3%) had late-onset sepsis (LOS). There were 6 deaths among those who had sepsis (9.3%). The predominant organisms in both early and LOS were Klebsiella and Staphylococcus aureus followed by Escherichia coli. Conclusion:The pattern of isolates is more or less similar to that seen in other NICU across the country. Klebsiella and S. aureus were two of the commonest organisms isolated in our study.

Bacterial isolates, antibiogram and outcomes of blood culture proven sepsis in neonates at a tertiary institution in South East Nigeria: a cross-sectional study

“…Also, contamination from mothers and caregivers may have led to an increase in the rate of transmission of Staphylococcus aureus in these neonates. However, studies conducted in India 7 and Pakistan, 28 found the presence of Gram-negative bacterial organisms to be more than Gram-positive.…”

“… 5 , 6 The spectrum of causative organisms responsible for neonatal infection varies across different geographical areas and changes over time, even in the same place. 7 Group B Streptococcus was found to be the most prevalent organism causing NNS in a study conducted in England, 8 while in India, 9 it was observed that Klebsiella pneumoniae was the most prevalent organism isolated. From a study in Ethiopia, 2 Staphylococcus aureus was observed to be the most prevalent organism isolated.…”