Bacterial Polyesters: Microbial Polyhydroxyalkanoates and Nonnatural Polyesters (Adv. Mater. 35/2020)

Choi, So Young; Cho, In Jin; Lee, Young Joon; Kim, Yeo-Jin; Kim, Kyung‐Jin; Lee, Sang Yup

doi:10.1002/adma.202070264

Cited by 6 publications

(8 citation statements)

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“…[ 91 ] To quantitatively evaluate the adhesion energy of P‐G hydrogel, lap shear tests and 180° peeling tests are performed between two pieces of P‐G hydrogels, with one hydrogel layer mimicking the biological tissue (Figure S6, Supporting Information). As it is common to use hydrogels as tissue mimics, [ 38,45,92 ] we first measure the peeling strength between two hydrogels to simulate the intranasal environment. We apply the P‐G hydrogel to another layer of P‐G hydrogel simulating the moist nasal mucosa and place it in a humid environment (90% RH, 37 °C) simulating the humidity in the nasal cavity.…”

Section: Resultsmentioning

confidence: 99%

“…[91] To quantitatively evaluate the adhesion energy of P-G hydrogel, lap shear tests and 180°peeling tests are performed between two pieces of P-G hydrogels, with one hydrogel layer mimicking the biological tissue (Figure S6, Supporting Information). As it is common to use hydrogels as tissue mimics, [38,45,92] we and enables long-term adhesion. d) Scanning electron microscopy (SEM) image of P-G hydrogel.…”

Section: Synthesis and Characterization Of P-g Hydrogelmentioning

confidence: 99%

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A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis

Liu,

Yu,

Guo

et al. 2023

Adv Healthcare Materials

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Bioadhesive hydrogels have attracted considerable attention as innovative materials in medical interventions and human‐machine interface engineering. Despite significant advances in their application, it remains critical to develop adhesive hydrogels that meet the requirements for biocompatibility, biodegradability, long‐term strong adhesion and efficient drug delivery vehicles in moist condition. We propose a biocompatible, biodegradable, soft and stretchable hydrogel made from a combination of a biopolymer (unmodified natural gelatin) and stretchable biodegradable poly(ethylene glycol) diacrylate (PEGDA) to achieve durable and tough adhesion, and explore its use for convenient and effective intranasal hemostasis and drug administration. Desirable hemostasis efficacy and enhanced therapeutic outcomes for allergic rhinitis are accomplished. Biodegradation enables spontaneous removal of materials without causing secondary damage and minimize medical waste. Preliminary trials on human subjects provide an essential foundation for practical applications. This work elucidates material strategies for biodegradable adhesive hydrogels, which are critical to achieve robust material interfaces and advanced drug delivery platforms for novel clinical treatments.This article is protected by copyright. All rights reserved

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Characterization Of P-g Hydrogelmentioning

confidence: 99%

A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis

Liu,

Yu,

Guo

et al. 2023

Adv Healthcare Materials

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“…Specifically, most Class-I PHA synthases, such as PhaCs from R. eutropha ( Ushimaru et al, 2014 ), Alcaligenes latus ( Park et al, 2012a ), Aeromonas Caviae and Chromobacterium sp . ( Choi et al, 2020 ), not only show effective activity on SCL PHA accumulation including 3HB, 3HP, 4HB and 3HV units, but also display polymerization capability of MCL PHA like 3HHx ( Antonio et al, 2000 ).…”

Section: Pha Synthasementioning

confidence: 99%

“…Of which, the monomers of SCL-, MCL- and LCL-PHA generally contain 2–5, 6–14 and over 15 carbon atoms, respectively. Because of the competitive material properties, PHA has attracted growing attentions of commercial interests in different application areas, such as medical implant ( Chen and Wu, 2005 ), cosmetic beads ( Choi et al, 2020 ), packaging ( Chen and Patel, 2012 ), agricultural film ( Chen, 2009 ), textile ( Chen, 2009 ), feeding additives ( Chen, 2009 ) and so on. In the past decades, intensive efforts have been made to generate various PHA productions consisting of diverse polymerized units with different carbon-chain-length and structures by genetically modified bacterial ( Chen and Jiang, 2017 ), such as Halomonas spp.…”

Section: Introductionmentioning

confidence: 99%

Advances and trends in microbial production of polyhydroxyalkanoates and their building blocks

Gao

Hao

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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With the rapid development of synthetic biology, a variety of biopolymers can be obtained by recombinant microorganisms. Polyhydroxyalkanoates (PHA) is one of the most popular one with promising material properties, such as biodegradability and biocompatibility against the petrol-based plastics. This study reviews the recent studies focusing on the microbial synthesis of PHA, including chassis engineering, pathways engineering for various substrates utilization and PHA monomer synthesis, and PHA synthase modification. In particular, advances in metabolic engineering of dominant workhorses, for example Halomonas, Ralstonia eutropha, Escherichia coli and Pseudomonas, with outstanding PHA accumulation capability, were summarized and discussed, providing a full landscape of diverse PHA biosynthesis. Meanwhile, we also introduced the recent efforts focusing on structural analysis and mutagenesis of PHA synthase, which significantly determines the polymerization activity of varied monomer structures and PHA molecular weight. Besides, perspectives and solutions were thus proposed for achieving scale-up PHA of low cost with customized material property in the coming future.

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“…[ 2 ] It is more promising by leveraging environmentally friendly and widely adaptable biomaterial tools, involving microorganisms and biomolecules, with quantitative yields, fast kinetics, high selectivity, and fidelity for REE separation. [ 3–17 ] However, there remain significant challenges for biomaterials in industry application due to their inefficiency in extracting high‐performance REE materials from ores. Therefore, developing a new generation of biosynthetic materials for agile biofoundry is necessary to obtain high‐value utilization of REEs.…”

Section: Introductionmentioning

confidence: 99%

The Construction of a Microbial Synthesis System for Rare Earth Enrichment and Material Applications

et al. 2023

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Rare earth materials play an irreplaceable role in biomedical and high technology fields. However, typical mining and extraction approaches to rare earth elements (REEs) often lead to severe environmental problems and resource wastage due to the involvement of hazardous chemicals. Although biomining shows elegant alternatives, there are still grand challenges to sustainably isolate and recover REEs in nature because of insufficient metal‐extracting microbes and RE‐scavenging macromolecular tools. To obtain high‐performance rare earth materials directly from rare earth ore, a new generation of biological synthesis strategies needs to be developed for the efficient preparation of REEs. The microbial synthesis system established here has achieved active biomanufacturing of high‐purity rare earth products. Further, through employing robust affinity columns bioconjugated with structurally engineered proteins, outstanding separation of Eu/Lu and Dy/La is acquired with the purity of 99.9% (Eu), 97.1% (La), and 92.7% (Dy). More importantly, in situ one‐pot synthesis of lanthanide‐dependent methanol dehydrogenase is well harnessed and exclusively adsorbs La, Ce, Pr, and Nd in RE tailing for advanced biocatalysis, indicating high value‐added application. Therefore, this novel biosynthetic platform provides an insightful roadmap to expand the scope of chassis engineering in terms of biofoundry and to manufacture valuable bioproducts related to REEs.

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Bacterial Polyesters: Microbial Polyhydroxyalkanoates and Nonnatural Polyesters (Adv. Mater. 35/2020)

Cited by 6 publications

References 0 publications

A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis

A Biodegradable, Adhesive, and Stretchable Hydrogel and Potential Applications for Allergic Rhinitis and Epistaxis

Advances and trends in microbial production of polyhydroxyalkanoates and their building blocks

The Construction of a Microbial Synthesis System for Rare Earth Enrichment and Material Applications

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