Bacterial polyesters grafted with poly(ethylene glycol): Behaviour in aqueous media

Domenek, Sandra; Langlois, Valérie; Renard, Estelle

doi:10.1016/j.polymdegradstab.2007.03.001

Cited by 24 publications

(15 citation statements)

References 16 publications

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“…The average molar mass of the modified PHAs is given in (7 days) is needed for the removal of no grafted PEG. The pH of the dialysis solution is not controlled and a little decrease of the average molar mass of PHOD-g-PEG was observed, because of some degradation, as explained in a previous study [29].…”

Section: Poly(3-hydroxyalkanoate)s Phasmentioning

confidence: 84%

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Adhesion and proliferation of human bladder RT112 cells on functionalized polyesters

Renard

Vergnol

Langlois

2011

IRBM

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Section: Poly(3-hydroxyalkanoate)s Phasmentioning

confidence: 84%

“…In a further reaction, poly(ethyleneglycol) (PEG) was grafted onto PHOD-COOH [28,29]. 257 mg of PHOD-COOH were dissolved in 12.8 mL of anhydrous methylene chloride.…”

Section: Methodsmentioning

confidence: 99%

Adhesion and proliferation of human bladder RT112 cells on functionalized polyesters

Renard

Vergnol

Langlois

2011

IRBM

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“…The weight loss was recorded and compared to the weight loss of the non graft polymer PHOD under similar conditions. 33 The PHOD sample was degraded into soluble fragments after three months whereas the grafted films remained stable during the same period of time. The results are shown in Fig.…”

Section: Graft Copolymersmentioning

confidence: 99%

Chemical modifications of bacterial polyesters: from stability to controlled degradation of resulting polymers

Renard¹,

Langlois²,

Guérin³

2007

Corrosion Engineering, Science and Technology

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Polyhydroxyalkanoates (PHAs) form an enlarged family of biopolyesters, which are biocompatible, biodegradable and non-toxic. Polyhydroxyalkanoates biodegradation corresponds to a hydrolysis involving endo-or exo-enzymatic systems in the breaking cleavage of esters bonds. This type of degradation is needed for environmental applications. In the case of therapeutic and biomedical uses, a simple hydrolysis is required. Hydrolytic degradation of PHAs is not evident as shown on poly(3-hydroxyoctanoate) (PHO) and is depending on the structure of the polyester and more particularly on the nature of the side chains. In some cases, blending with others polymers has decreased PHAs crystallinity and has made easier hydrolysis. Another route consists in the preparation of unsaturated PHAs which can be chemically modified. Pendant double bonds have been turned into carboxylic, hydroxyl or epoxy groups. Moreover these reactive functions were used for grafting oligomers of hydrolysable polylactic acid (PLA) or hydrophilic polyethylene glycol (PEG). Otherwise block copolymers with polycaprolactone (PCL) have been prepared, aiming at nanoparticles formation in the view of drug release. Therefore, the hydrophilic/ hydrophobic balance of these materials was controlled by chemical modification and their stability/hydrolysis has been studied. Results have shown that the most suitable products in regard to hydrolysis concern PHAs containing carboxylic groups in side chains, noted poly(3hydroxyoctanoate-co-9-carboxy-3-hydroxydecanoate) and its derivatives. Carboxylic groups promote water penetration into the polymer and participate to ester groups hydrolysis through better water penetration and catalysis.

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“…Original compositions were obtained, which included high levels of unsaturated monomers. The unsaturated mcl PHAs can be easily modified to produce functionalized polymers and constitute a promising approach to expend bacterial polyesters to be used in the medical and environmental areas [52,53].…”

Section: Bacterial Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

Microbial mats in French Polynesia and their biotechnological applications

Guézennec

Moppert

Raguénès

et al. 2011

Process Biochemistry

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a b s t r a c tIt is well known that microorganisms well-adapted to survival in extreme ecosystems could be considered as new sources of biomolecules that have biotechnological importance. On French Polynesian atolls, microbial mats are developing in water ponds exposed to fluctuations in physical and chemical parameters. In these microbial mats, which are called "kopara" by the inhabitants, bacteria coexist with cyanobacteria, and a synergistic relationship may exist between these two types of living microorganisms. A large number of cyanobacteria and bacteria have been isolated from different mats. Under laboratory conditions, these microorganisms were shown to produce various exopolymers, including exopolysaccharides and poly-␤-hydroxyalkanoates, along with pigments for further commercial developments. This manuscript gives an overview of substances isolated and characterized from these bacteria and cyanobacteria and discusses their potential applications in biotechnology.

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Bacterial polyesters grafted with poly(ethylene glycol): Behaviour in aqueous media

Cited by 24 publications

References 16 publications

Adhesion and proliferation of human bladder RT112 cells on functionalized polyesters

Adhesion and proliferation of human bladder RT112 cells on functionalized polyesters

Chemical modifications of bacterial polyesters: from stability to controlled degradation of resulting polymers

Microbial mats in French Polynesia and their biotechnological applications

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