Bacterial Pneumonia Due to<i>Bordetella bronchiseptica</i>in a Patient with Acute Leukemia

Gómez, Lucía; Grazziutti, Monica; Sumoza, David; Beran, Miloslav; Rolston, Kenneth V. I.

doi:10.1086/517630

Cited by 24 publications

(23 citation statements)

References 4 publications

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“…In a review of the literature, the majority of patients infected with B. bronchiseptica had at least one predisposing disease such as acute lymphocytic leukemia,3 chronic lymphocytic leukemia,4,5 lymphopenia associated with temolozolide treatment for glioblastoma,6 cystic fibrosis7 or had undergone hematopoietic stem cell transplantation (HSCT),8,9 or lung transplantation 10. Our study adds three new cases of B. bronchiseptica pneumonia to the current literature, which includes a patient with malignant thymoma, a patient with adenocarcinoma of unknown primary origin with brain metastases, and a patient with a history of lung and supraglottic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The response to various antimicrobials is similar to that expected of a gram-negative non-fermentative organism, but it is essential to choose one that has good intracellular penetration 3,4. Though B. bronchiseptica is an extracellular organism, recent studies have shown that this organism is able to invade and persist in eukaryotic cells, like phagocytes and even epithelial cells 35,36.…”

Section: Discussionmentioning

confidence: 99%

“…Such animals include guinea pigs, rats, mice, ferrets, horses, chicken, mice, primates and koala bears. The spectrum of illnesses caused by B. bronchiseptica in susceptible animals includes tracheobronchitis of rabbits and guinea pigs (snuffles) and dogs (kennel cough), as well as turbinate atrophy in swine 1–3…”

Section: Introductionmentioning

confidence: 99%

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Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Yacoub

Katayama

Tran

et al. 2014

Mediterr J Hematol Infect Dis

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Organisms that are not known to cause serious infection in the immunocompetent population can, in fact, cause devastating illness in immunosuppressed neutropenic populations especially those who are undergoing hematopoietic stem cell transplantation (HSCT), and solid organ transplantation or a history of malignancy. One organism of interest isolated from immunosuppressed patients at our institution was Bordetella bronchiseptica. It is known to cause respiratory tract disease in the animal population which includes dogs, cats, and rabbits. This organism rarely causes serious infection in the immunocompetent population. However; in immunosuppressed patients, it can cause serious pulmonary disease. We present three cases of B. bronchiseptica pneumonia in patients with a history of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Yacoub

Katayama

Tran

et al. 2014

Mediterr J Hematol Infect Dis

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“…Several authors have reported complete eradication of infection with 2 weeks of therapy (5,15,19). Neutropenic or other immunocompromised patients may require prolonged antibiotic therapy of 4 or more weeks to attain complete clinical recovery (9). This case represents the first report of an infected branchial cleft cyst due to B. bronchiseptica in an immunocompetent patient, expanding the spectrum of clinical disease that may be seen with this organism.…”

Section: Case Reportmentioning

confidence: 83%

“…There are no definitive radiographic features associated with B. bronchiseptica pulmonary infections, but diffuse infiltrates (4), interstitial pneumonia (5,6), and lobar pneumonia (1,6,9,19) are the most frequent findings. Cavitary lesions are rarely identified (6,7).…”

Section: Case Reportmentioning

confidence: 99%

Infected Branchial Cleft Cyst Due to Bordetella bronchiseptica in an Immunocompetent Patient

Brennan

Wadlin

et al. 2001

J Clin Microbiol

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A healthy 23-year-old man with fever and a tender mass in his right anterior neck was found to have a branchial cleft cyst infected with Bordetella bronchiseptica. Initial testing suggested a Brucella species, but further laboratory testing identified the organism definitively. B. bronchiseptica infection in healthy adults is an unusual event. CASE REPORTA previously healthy 23-year-old man was admitted to our hospital with a fever of 39°C (102°F) and a tender mass in his right anterior neck. The patient initially noted a small, painless swelling in his right neck 10 days prior to presentation. Over the ensuing week, the mass progressively enlarged, becoming increasingly erythematous and tender, and the patient noted daily spiking fevers. An immigrant from rural Mexico, he had been living in the United States for 6 months, working on a farm in central Pennsylvania as a mushroom collector. He reported no sick contacts. There were numerous goats, dogs, and cats on the farm, but he denied having been bitten or scratched by any of them. He denied having consumed unpasteurized dairy products.Physical examination revealed a young, thin male in no acute distress. He was normotensive, with a temperature of 39.1°C (102.2°F) on admission. The right anterior neck mass measured 2 by 4 cm and was firm, tender, and nonmobile. The skin overlying the mass was warm and erythematous. No draining sinus or fistula was present, and he had no associated lymphadenopathy or rashes. The remainder of his exam was unremarkable.The patient had an elevated white blood cell count of 13,200/ l, with 78% polymorphonuclear leukocytes. Tests of liver function were normal, and 2 sets of blood cultures showed no growth. A rapid plasma reagin test was negative, and tests for human immunodeficiency virus were nonreactive. The patient's chest radiograph was normal. A computed tomographic scan of the neck showed a 2.5-by 4.5-cm multilocular, necrotic mass in the right neck with associated induration of the adjacent soft tissues and deviation of the trachea (Fig. 1). No lymphadenopathy was present.Fine-needle aspiration of the mass was performed, the material was stained with Papanicolaou stain, and numerous neutrophils and squamous epithelial cells were evident. The large number of squamous epithelial cells in the aspirate confirmed the presence of a branchial cleft cyst. Acid-fast bacilli were not seen by Kinyoun staining of the specimen. Gram staining of the aspirate showed leukocytes with intracellular, pleomorphic, gram-negative coccobacilli. Based on this Gram stain and the patient's history of animal exposures, a presumptive diagnosis of brucellosis was made. The patient was subsequently begun on intravenous doxycycline and rifampin.A sample of the aspirate was inoculated onto blood, chocolate, and brucella agar plates and incubated at 37°C in an atmosphere of 5 to 10% carbon dioxide for 5 days. Multiple translucent, spheroidal colonies approximately 2 to 3 mm in diameter were isolated. The isolate was positive in tests for catalase, oxidase, an...

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Rhodococcus equi and Bordetella bronchiseptica

Touchie

Community-Acquired Pneumonia

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Bacterial Pneumonia Due toBordetella bronchisepticain a Patient with Acute Leukemia

Cited by 24 publications

References 4 publications

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Bordetella Bronchiseptica in the Immunosuppressed Population – A Case Series and Review.

Infected Branchial Cleft Cyst Due to Bordetella bronchiseptica in an Immunocompetent Patient

Rhodococcus equi and Bordetella bronchiseptica

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