Bacterial pneumonia complicating adenoviral pneumonia

Ellenbogen, Charles; Graybill, John R.; Silva, Joseph; Homme, P J

doi:10.1016/0002-9343(74)90594-4

Cited by 28 publications

(3 citation statements)

References 27 publications

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“…Similarly, human bacterial respiratory disease often requires a predisposing insult to the tracheobronchial tree. Viral infections (4,11) endotracheal intubation (8), and chemical injury (2) are some of the recognized antecedents of bacterial respiratory infections. In light of the association between these various insults and respiratory disease, we have studied the adherence of bacteria to the normal and injured tracheobronchial tree.…”

mentioning

confidence: 99%

Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation

Ramphal¹,

Small²,

Shands³

et al. 1980

Infect Immun

161

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Adherence of Pseudomonas aeruginosa to normal, injured, and regenerating tracheal mucosa was examined by scanning electron microscopy. Uninfected and influenza-infected murine tracheas were exposed to six strains of P. aeruginosa isolated from human sources and one strain of plant origin. All of the strains tested adhered to desquamating cells of the infected tracheas, but not to normal mucosa, the basal cell layer, or the regenerating epithelium. Adherence increased when the incubation time of the bacteria with the trachea was prolonged. Strains isolated from human tracheas appeared to adhere better than strains derived from the urinary tract. After endotracheal intubation of ferrets, P. aeruginosa adhered only to the injured cells and to areas of exposed basement membrane. We call this phenomenon "opportunistic adherence" and propose that alteration of the cell surfaces or cell injury facilitates the adherence of this bacterium and that adherence to injured cells may be a key to the pathogenesis of opportunistic Pseudomonas infections.

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mentioning

confidence: 99%

Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation

Ramphal¹,

Small²,

Shands³

et al. 1980

Infect Immun

161

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“…Minocycline given prophylactically failed to prevent invasion. 91 Mycoplasma caused fatal sepsis, pericarditis, diaphragmatic myonecrosis and patchy pneumonia in a patient.92 Contrary to earlier belief, in one study M. pneumoniae infections were more common in young children than in adults. The lower respiratory tract often was involved.…”

Section: Pneumococcal Pneumoniamentioning

confidence: 89%

Infectious diseases: fortieth and final annual review of significant publications

Reimann

1975

Postgraduate Medical Journal

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According to recent comment, the importance of infections and the interest in them have reached a nadir.1 But, by reviewing these Reviews published annually since 1935, infectious diseases actually have increased in importance, if not in interest. For example, the death rate from infections is about the same now as it was in 1935, but depends upon different causal microbes. Some diseases have almost disappeared only to be replaced by others. Great advances in the knowledge of viral infections, microbic biology and immunology; the multiplicity of vaccines and antimicrobic drugs, their proper use and limited value; the unceasing resurgence of epidemics; the rising incidence of iatrogenic and nosocomial infections; and the recognition of exotic diseases imported from persistent endemic areas are largely beyond the grasp of generalist physicians and surgeons. They require specialized knowledge and undiminished interest.

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“…bacteria include S. pneumoniae, Group A strepto-· cocci, H. influenzae, S. aureus, and Group Y Neisseria meningitidis. 54 In military recruits, an increased frequency of Group Y meningococcal suprainfection has been observed because these microorganisms commonly colonize the nasopharynx in this population. Administration of antibiotics during the course of the adenovirus pneumonia does not prevent bacterial suprainfection.…”

Section: Adenovirus Pneumoniamentioning

confidence: 99%

Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses

Luby

1987

The American Journal of the Medical Sciences

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Pneumonias in adults due to mycoplasma, chlamydiae, and viruses are a common clinical problem. These microorganisms contribute to the etiologies in 6-35% of all cases of pneumonia and are the sole pathogens in 1-17% of hospitalized cases. Important trends and developments in the field include the emergence of a Chlamydia psittaci strain (TWAR) that is passaged from human to human, causes a mycoplasma-like illness, and that is relatively resistant to erythromycin, the recognition of respiratory syncytial virus as a pathogen in nursing home outbreaks and in immunosuppressed adults, the continuing high lethality of fully developed influenza pneumonia, the efficacy of acyclovir and adenine arabinoside in limiting the complications of varicella-zoster virus infections, and the increasing frequency of pneumonia caused by cytomegalovirus and the severity of this disorder in highly immunosuppressed patients. Developments in the rapid diagnosis and therapy of respiratory syncytial virus infections with an aerosolized antiviral drug in children may pave the way for comparable advances in difficult pneumonias in adult patients.

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Bacterial pneumonia complicating adenoviral pneumonia

Cited by 28 publications

References 27 publications

Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation

Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation

Infectious diseases: fortieth and final annual review of significant publications

Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses

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