Bacterial pathogens and their susceptibility to antibiotics among mothers with premature rupture of membranes at a teaching hospital in western uganda

Abstract

Background: Premature rupture of membranes (PROM) remains a great burden to mothers and their unborn children all over the world with several adverse maternal and fetal outcomes. This study aimed at determining common bacterial pathogens and their susceptibility patterns in women with PROM at Kampala International University Teaching Hospital (KIU-TH). Methods: This was a cross-sectional study conducted in the months of September 2019 to November 2019. A total of 334 pregnant mothers above 28 weeks of pregnancy admitted in maternity ward of KIU-TH were consecutively enrolled. Interviewer administered questionnaires and laboratory forms were used to collect data. Endocervical swabs were obtained from those with PROM and taken to the laboratory for culture and susceptibility tests. Descriptive statistics were used using STATA 14.2. Results: 46 (13.8%) mothers had PROM. Of these, the most common bacterial pathogens identified were S. aureus (29.6%), E. coli (25.9%) and N. gonorrhoeae (25.9%). Antibacterial susceptibility tests revealed highest sensitivity to imipenem (100%), nitrofurantoin (92.6%), cloxacillin (85.2%) and azithromycin (81.5%). Total resistance to amoxacillin, ceftriaxone and ampicillin was found. Conclusion: Women with PROM predominatly have Staphylococcus aureus, Escherichia coli and Neisseria gonorrhoeae. Imipenem, nitrofurantoin, cloxacillin and azithromycin are the most effective antibiotics among patients with PROM.

Determinants Impacting the Use of Antibiotics Among Patients Visiting the Dental Clinic at Kampala International University Teaching Hospital in Bushenyi-Ishaka Municipality, Western Uganda

“…Antibiotics are one of the most cost-effective, lifesaving medicines and contribute to the extended lifespan of humankind [2]. However, the effect of antibiotics is compromised by the rapid escalation of antibiotic resistance, which, combined with the paucity of development of new antibiotics (or antibiotic combinations) with novel modes of action is considered a major global threat [3,4]. World Health Organization (WHO) estimated that 80% of antibiotics are used in the community, of which about 20-50% are used inappropriately.…”