Bacterial oxidation of polyethylene glycol

Kawai, Fusako; Kimura, Takuhei; Fukaya, Masahiro; Tani, Yoshiki; Ogata, Kôichi; Ueno, Tamio; Fukami, Hiroko

doi:10.1128/aem.35.4.679-684.1978

Cited by 95 publications

(42 citation statements)

References 9 publications

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“…The fact that only one hydroxyl group was attacked and other remained intact gets support from stoichiometry of the reaction as well. Literature survey shows that similar types of oxidative products were reported [20][21][22][24][25][26] .…”

Section: Product Analysissupporting

confidence: 53%

Catalytic Effect of Cetyltrimethylammonium Bromide on the Oxidation of Triethylene glycol by Chloramine‐T in Acidic Medium

Sharma¹,

Sharma²,

Bhagwat³

2008

Journal of Chemistry

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The kinetics and mechanism of cetyltrimethylammonium bromide catalyzed oxidation of triethylene glycol [2,2'-ethylene diqxybis(ethanol)] by chloramine-T in acidic acid medium have been investigated. The reaction is first order dependence on chloramine-T and fractional order for triethylene glycol with excess concentration of other reactants. The catalytic effect due to cetyletrimethylammonium bromide has been studied. The small salt effect and increase in the reaction rate with increasing dielectric constant suggest the involvement of neutral molecule in the rate-determining step. The addition ofp-toluene sulfonamide retards the reaction rate. The effect of chloride ion on the reaction also studied. The effect of temperature on the reaction has been investigated in the temperature range 313-333K and thermodynamic parameters were calculated from the Arrhenious plot. A tentative mechanism consistent with the experimental results has been proposed.

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Section: Product Analysissupporting

confidence: 53%

Catalytic Effect of Cetyltrimethylammonium Bromide on the Oxidation of Triethylene glycol by Chloramine‐T in Acidic Medium

Sharma¹,

Sharma²,

Bhagwat³

2008

Journal of Chemistry

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“…However, some studies found that PEG can be oxidized by enzymes and some proteins still adsorb on to it. 10,14,15 Natural products as bovine serum albumin (BSA) are also exploited to form a protective layer on the NPs to improve biocompatibility and transport of the NPs; 16 for instance, novel commercial drugs, such as Abraxane, incorporate albumin in the drug formulation to efficiently accumulate the drug in the tumor due to an enhanced permeability and retention and to reduce the risk of hypersensitivity reactions. Drug release in albumin carriers can be triggered naturally by protease digestion or pH-responsive systems; the payload can be tuned by the amount of albumin on the NPs, and the unfolding of the protein on the NP can facilitate their clearance by phagocytes.…”

Section: Introductionmentioning

confidence: 99%

Albumin-coated SPIONs: an experimental and theoretical evaluation of protein conformation, binding affinity and competition with serum proteins

Perálvarez-Marín

Minelli

et al. 2016

Nanoscale

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The variety of nanoparticles (NPs) used in biological applications is increasing and the study of their interaction with biological media is becoming more important. Proteins are commonly the first biomolecules that NPs encounter when they interact with biological systems either in vitro or in vivo. Among NPs, super-paramagnetic iron oxide nanoparticles (SPIONs) show great promise for medicine. In this work, we study in detail the formation, composition, and structure of a monolayer of bovine serum albumin (BSA) on SPIONs. We determine, both by molecular simulations and experimentally, that ten molecules of BSA form a monolayer around the outside of the SPIONs and their binding strength to the SPIONs is about 3.5 × 10(-4) M, ten times higher than the adsorption of fetal bovine serum (FBS) on the same SPIONs. We elucidate a strong electrostatic interaction between BSA and the SPIONs, although the secondary structure of the protein is not affected. We present data that supports the strong binding of the BSA monolayer on SPIONs and the properties of the BSA layer as a protein-resistant coating. We believe that a complete understanding of the behavior and morphology of BSA-SPIONs and how the protein interacts with SPIONs is crucial for improving NP surface design and expanding the potential applications of SPIONs in nanomedicine.

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“…Examples of Class 4 communities in which the community, but not its individual species, effects a concerted attack on the substrate, are abundant [see reviews by Bull (1980) and Bull & Slater (1982)l. Such communities have, for instance, been incriminated in the degradation of xenobiotics as diverse as poly(ethy1ene glycol) (Kawai et al, 1977) and nylon polymers (Kinoshita et al, 1975), linear alkylbenzene sulphonate detergents (Johanides & Hrsak, 1976), phenols such as orcinol (Osman et af., 1976), cyanideand acrylonitrile-containing wastes, herbicides such as pichloram (Lovatt er al., 1978), dalapon (Senior et af., 1976) and the related 2-chloropropionamide (Reanney et af., 1983).…”

Section: Nj Ukmentioning

confidence: 99%

Xenobiotic breakdown by mixed cultures

Cain

1984

Biochemical Society Transactions

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Bacterial oxidation of polyethylene glycol

Cited by 95 publications

References 9 publications

Catalytic Effect of Cetyltrimethylammonium Bromide on the Oxidation of Triethylene glycol by Chloramine‐T in Acidic Medium

Catalytic Effect of Cetyltrimethylammonium Bromide on the Oxidation of Triethylene glycol by Chloramine‐T in Acidic Medium

Albumin-coated SPIONs: an experimental and theoretical evaluation of protein conformation, binding affinity and competition with serum proteins

Xenobiotic breakdown by mixed cultures

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