Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects

Saltzman, John R.; Kowdley, Kris V.; Pedrosa, Marcos; Sepe, Thomas; Golner, B B; Perrone, Gayle; Russell, Robert M.

doi:10.1016/0016-5085(94)90693-9

Cited by 146 publications

(72 citation statements)

References 36 publications

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“…We chose 20 ppm of H 2 above the baseline as our definition of a positive test in keeping with previous studies [12][13][14]. This is higher than some studies, which have used 12 ppm [11] and 10 ppm [10,15,16]. The exact figure chosen will of course influence the number of positive tests and thus the sensitivity and specificity of the test.…”

Section: Discussionmentioning

confidence: 99%

Small bowel bacterial overgrowth in subjects living in residential care homes

Lewis¹

1999

Age and Ageing

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Objectives: in elderly people, bacterial overgrowth of the small bowel may be occult. The significance of positive breath tests are uncertain: many fit elderly subjects with positive tests show no evidence of malabsorption. We assessed the prevalence and significance of bacterial overgrowth in the small bowel in a relatively unselected elderly population. Methods: residents of seven elderly people's homes had a glucose hydrogen breath test. A medical history and anthropomorphic measurements were recorded. Volunteers with positive breath tests were given doxycycline. After 4 months all volunteers were reassessed. Results: of 140 residents, 62 were tested. Nine (14.5%) had a positive breath test. There was no difference in anthropomorphic and bowel habit data between those with positive and those with negative breath tests. After 4 months of antibiotic treatment, volunteers with a positive breath test had increased weight and body mass index, while those with a negative test had decreased weight and body mass index. Conclusions: the percentage of volunteers with a positive breath test was much lower than in previous studies. This may be due to the relatively unselected nature of the volunteers. Treatment of bacterial overgrowth resulted in a small but significant improvement in anthropometric indices. The lack of association of positive breath tests with baseline anthropomorphic measurements or bowel habit highlights the occult nature of the bacterial overgrowth and questions its clinical importance.

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Section: Discussionmentioning

confidence: 99%

Small bowel bacterial overgrowth in subjects living in residential care homes

Lewis¹

1999

Age and Ageing

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“…También se ha asociado a trastornos en la motilidad gastrointestinal, en especial del complejo motor migratorio (CMM) 11 y frente a una disminución de la secreción gástrica de ácido clorhídrico 12 . En la mayoría de los pacientes esta condición produce síntomas, que incluyen alteraciones del hábito intestinal, principalmente diarrea, dolor abdominal, distensión y meteorismo, síntomas que son similares a los que presentan los pacientes con SII.…”

Section: N V E S T I G a C I ó Nunclassified

Sobrecrecimiento bacteriano en trastornos funcionales del intestino

Madrid

et al. 2007

Rev. méd. Chile

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“…This condition occurs primarily as a result of low intestinal motility, with hypochlorhydria having less clinical importance [57]. Low gastrointestinal motility can result from gastrointestinal surgery, including gastric bypass, jejunal diverticulosis, and blind-loop syndrome after intestinal surgery, or structural abnormalities, including diverticulosis in the duodenum or jejunum.…”

Section: Bacterial Overgrowthmentioning

confidence: 99%