Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut

Kim, Eun Kyoung; Lee, Kyung Ah; Hyeon, Do Young; Kyung, Minsoo; Jun, Kyu Yeon; Seo, Seung Hee; Hwang, Daehee; Kwon, Young Joo; Lee, Won Jae

doi:10.1016/j.chom.2020.01.025

Cited by 42 publications

(34 citation statements)

References 67 publications

(84 reference statements)

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“…Finally, the Drosophila immune system can recognize metabolites that are specific to pathogens, and absent from commensals. Uracil, which is only produced by opportunistic pathogens as a by-product of quorum-sensing [50 ] triggers a Duox-dependant release of ROS through Hedgehog-induced signaling upon infection [51,52].…”

Section: Commensal Microbes and Immune Signalingmentioning

confidence: 99%

How commensal microbes shape the physiology of Drosophila melanogaster

Grenier

Leulier

2020

Current Opinion in Insect Science

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The interactions between animals and their commensal microbes profoundly influence the host's physiology. In the last decade, Drosophila melanogaster has been extensively used as a model to study host-commensal microbes interactions. Here, we review the most recent advances in this field. We focus on studies that extend our understanding of the molecular mechanisms underlying the effects of commensal microbes on Drosophila's development and lifespan. We emphasize how commensal microbes influence nutrition and the intestinal epithelium homeostasis; how they elicit immune tolerance mechanisms and how these physiological processes are interconnected. Finally, we discuss the importance of diets and microbial strains and show how they can be confounding factors of microbe mediated host phenotypes.

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Section: Commensal Microbes and Immune Signalingmentioning

confidence: 99%

How commensal microbes shape the physiology of Drosophila melanogaster

Grenier

Leulier

2020

Current Opinion in Insect Science

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“…Further work is needed to identify which affected host functions contribute to longevity, and whether similar longevity phenotypes may obscure other trait differences. Host-microbe interactions become even more complex when some members of the microbiome shift from a 320 commensal to a pathogen status and vice versa [117]. This can happen due to temperature, presence of pathogens, and other unknown factors [118,119].…”

Section: Adult Nutrition and Fitnessmentioning

confidence: 99%

The Microbiome and Mosquito Vectorial Capacity: Rich Potential for Discovery and Translation

Cansado-Utrilla

Zhao

McCall

et al. 2020

Preprint

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Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. Similar to higher organisms, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence and pathogen extrinsic incubation period all influence pathogen transmission. Interestingly, the mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps in the biology of the mosquito – microbe symbiosis that need to be addressed in order to understand these interactions more thoroughly and exploit them efficiently. Here, we review current evidence of the impacts of the microbiome on aspects of vectorial capacity highlighting opportunities for novel vector control strategies and areas where further studies are required.

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“…Both types of bacteria can produce the furanyl dibasic compound (2S, 4S)-2-methyl-2,3,3,4tetrahydroxytetrahydrofuran borate (AI-2). Intestinal microbiota also communicates with each other via quorum sensing signals, transforming intestinal pathogenic commensal bacteria into pathogenic bacteria, and thus impacts on host health (Kim et al, 2020). While V. cholerae itself can produce three QS signal molecules, including inter-species communication autoinducer AI-2 (Schauder et al, 2001;Chen et al, 2002), intra-genusspecific autoinducer (S)-3-hydroxytridecan-4-one (CAI-1) (Kelly et al, 2009) and 3,5-dimethylpyrazin-2-ol (DPO) (Herzog et al, 2019).…”

Section: Qs-depended Crosstalk Between Gut Microbiota and V Choleraementioning

confidence: 99%

Crosstalks Between Gut Microbiota and Vibrio Cholerae

Qin

Yang

Chen

et al. 2020

Front. Cell. Infect. Microbiol.

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Vibrio cholerae, the causative agent of cholera, could proliferate in aquatic environment and infect humans through contaminated food and water. Enormous microorganisms residing in human gastrointestinal tract establish a special microecological system, which immediately responds to the invasion of V. cholerae, through "colonization resistance" mechanisms, such as antimicrobial peptide production, nutrients competition, and intestinal barrier maintenances. Meanwhile, V. cholerae could quickly sense those signals and modulate the expression of relevant genes to circumvent those stresses during infection, leading to successful colonization on the surface of small intestinal epithelial cells. In this review, we summarized the crosstalks profiles between gut microbiota and V. cholerae in the terms of Type VI Secretion System (T6SS), Quorum Sensing (QS), Reactive Oxygen Species (ROS)/pH stress, and Bioactive metabolites. These mechanisms can also be applied to molecular bacterial pathogenesis of other pathogens in host.

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Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut

Cited by 42 publications

References 67 publications

How commensal microbes shape the physiology of Drosophila melanogaster

How commensal microbes shape the physiology of Drosophila melanogaster

The Microbiome and Mosquito Vectorial Capacity: Rich Potential for Discovery and Translation

Crosstalks Between Gut Microbiota and Vibrio Cholerae

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