Bacterial Nanocellulose: The Future of Controlled Drug Delivery?

Pötzinger, Yvette; Kralisch, Dana; Fischer, Dagmar

doi:10.4155/tde-2017-0059

Cited by 63 publications

(28 citation statements)

References 47 publications

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“…Nevertheless, biocellulose is well suited for, and mainly used in, the food and cosmetics industries and is traded worldwide. The utilization of this type of BNC in medical, pharmaceutical, and advanced technical applications is, however, hampered by varying culture conditions and feedstock qualities, possible impurities, and a comparatively low material stability [49].…”

Section: Bnc Production and Designmentioning

confidence: 99%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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Nanocelluloses are natural materials with at least one dimension in the nano-scale. They combine important cellulose properties with the features of nanomaterials and open new horizons for materials science and its applications. The field of nanocellulose materials is subdivided into three domains: biotechnologically produced bacterial nanocellulose hydrogels, mechanically delaminated cellulose nanofibers, and hydrolytically extracted cellulose nanocrystals. This review article describes today's state regarding the production, structural details, physicochemical properties, and innovative applications of these nanocelluloses. Promising technical applications including gels/foams, thickeners/stabilizers as well as reinforcing agents have been proposed and research from last five years indicates new potential for groundbreaking innovations in the areas of cosmetic products, wound dressings, drug carriers, medical implants, tissue engineering, food and composites. The current state of worldwide commercialization and the challenge of reducing nanocellulose production costs are also discussed.

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Section: Bnc Production and Designmentioning

confidence: 99%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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“…Last but not least, the attractiveness of this innovative biofabricated material has further increased due to its animal and human-free origin [47]. Its biosynthesis opens up the opportunity to develop biotechnological production to significantly influence and control the final BC shape and material features.…”

Section: Bacterial Cellulosementioning

confidence: 99%

“…Furthermore, an increasing number of studies report on drug delivery systems based on BC for dermal applications [47]. To avoid the risk of bacterial infections, e.g.…”

Section: Drug-delivery Systemsmentioning

confidence: 99%

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Antón-Sales

Beekmann

Laromaine

et al. 2019

CDT

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In this mini-review, we highlight the potential of the biopolymer bacterial cellulose to treat damaged epithelial tissues. Epithelial tissues are cell sheets that delimitate both the external body surfaces and the internal cavities and organs. Epithelia serve as physical protection to underlying organs, regulate the diffusion of molecules and ions, secrete substances and filtrate body fluids, among other vital functions. Because of their continuous exposure to environmental stressors, damage to epithelial tissues is highly prevalent. Here, we first compare the properties of bacterial cellulose to the current gold standard, collagen, and then we examine the use of bacterial cellulose patches to heal specific epithelial tissues; the outer skin, the ocular surface, the oral mucosa and other epithelial surfaces. Special emphasis is made on the dermis since, to date, this is the most widespread medical use of bacterial cellulose. It is important to note that some epithelial tissues represent only the outermost layer of more complex structures such as the skin or the cornea. In these situations, depending on the penetration of the lesion, bacterial cellulose might also be involved in the regeneration of, for instance, inner connective tissue.

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“…The hydroxyl groups on the surface of BC provide the possibility of interaction by chemical bonds and electrostatic adsorption [26,27]. In spite of growing number of publications about BC modifications for wound healing, there is a limiting application of BC composites as drugdelivery systems [28].…”

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing

Zmejkoski

Spasojević

Orlovska

et al. 2018

International Journal of Biological Macromolecules

124

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Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.

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Bacterial Nanocellulose: The Future of Controlled Drug Delivery?

Cited by 63 publications

References 47 publications

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing

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