2023
DOI: 10.1101/2023.02.16.528894
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Bacterial multispecies invasion of human epithelial bladder cells

Abstract: Urinary tract infections (UTIs) are a worsening global health problem. Multispecies bacterial UTIs are common but are poorly recognized and understood. Here we developed host cell co-infection models combined with high resolution imaging to compare single- and multi-species infections with common uropathogens, uropathogenicEscherichia coli(UPEC),Klebsiella pneumoniaeandEnterococcus faecalis. We demonstrate cooperation and direct interactions specifically between UPEC andE. faecaliswithin host cells that corres… Show more

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