Bacterial microleakage and pulpal inflammation in experimental cavities

Browne, R.M.; Tobias, R. S.; Crombie, I.K.; Plant, C G

doi:10.1111/j.1365-2591.1983.tb01318.x

Cited by 59 publications

(29 citation statements)

References 22 publications

(17 reference statements)

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“…This leakage is commonly referred to as microleakage. Articles by Brannstrom and Nyborg (1973), Skogedal andEriksen (1976), Bergenholtz et al (1982), Browne et al (1983), andBrdnnstrom (1984) indicate that pulpal inflammation in restored teeth is due to the penetration of bacteria and their by-products along the tooth/restoration interface rather than to the direct effects of the restorative material.…”

Section: Introductionmentioning

confidence: 99%

Microleakage of Three Cement Bases

Heys

Fitzgerald

1991

J Dent Res

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The purpose of this study was to evaluate the ability of a glassionomer cement-base material to prevent bacterial penetration along the dentin interface and to compare it with two conventional cement-base materials. A total of 107 Class 5 restorations was placed in Rhesus monkey teeth by means of three test materials [zinc oxide-eugenol (ZOE), copalite varnish + zinc phosphate cement base (V + ZP), and a glass-ionomer lining cement (GI)], with unetched and unbonded resin composite used alone as a control material and as a final restoration over the test base materials. Following disinfection, Class 5 cavities were prepared on the buccal surfaces of the teeth to the inner one-half of dentin. A sterile filter-paper disk was then placed on the axial wall and covered with a Teflon disk. Next, the cavities were based to the dento-enamel junction with one of the test base materials and finally restored with unetched and unbonded resin composite. After five and 16 weeks, the filter-paper disks were retrieved and cultivated for the presence and type of bacteria. The five-week results showed positive growth in two groups: the composite-only controls and the V + ZP group. The 16-week results showed growth in all of the test groups, but only one of nine teeth showed growth in the zinc oxide-eugenol group and one of 16 teeth in the glassionomer group. The results of this study indicate that under the conditions tested, a glass-ionomer base was capable of minimizing bacterial penetration along the material-tooth interface.

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Section: Introductionmentioning

confidence: 99%

Microleakage of Three Cement Bases

Heys

Fitzgerald

1991

J Dent Res

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“…1-4 days, while the observations of Langeland et al (11) and Block et al (4) were made after 75-105 days and 28 days (respectively). In our study such autolysis must have taken place be- m An enzyme iiistociiomicai study et al (14,15) have stressed the cause and effect association that exists between the presence of bacteria at the filling material/cavity wall interface and the presence of pulpal inflammation. IB).…”

Section: Discussionmentioning

confidence: 76%

An enzyme histochemical study of the influence of formocresol and calcium hydroxide on the dental pulp

Eronat

Mallem

Wijnbergen

1988

Dental Traumatology

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Eronat N, van Mullem PJ, Wijnbergen M. An enzyme histochemical study of the infiuence of formocresol and calcium hydroxide on the dental pulp. Endod Dent Traumatol 1988; 4: 37-43.Abstract -Sections of goat incisor pulps were studied after a 5min application of formocresol (FC) or after calcium hydroxide or saline/ZnOE treatment followed by freeze-sectioning. After 3-7 days the incisal part of the pulp was necrotic, as shown by absence of lactate dehydrogenase (LDH) activity. The necrotic zone was much larger after FC than after saline/ZnOE or calcium hydroxide. The LDH negative area after application of FC appeared to consist of a layer showing nuclei that were wellpreserved by the formaldehyde from the FC, and an area of tissue breakdown, which showed no or a reduced structure according to hematoxylin atid eosin. Well-preserved nuclei were not found in the 2 other groups. After 14 days all necrotic tissue, except that subjacent to calcium hydroxide, had been replaced by vital (LDH-positive) tissue. After saline/ZnOE or calcium hydroxide treatment, hard-tissue formation was found in all teeth, and after FC treatment in the majority of teeth.

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“…It is well-documented that the setting reaction of dental restorative materials leads to the formation of contraction gaps at the tooth/restoration interface which can provide an environment for bacterial colonization (Mejare et al, 1979;Browne et al, 1983). Since marginal leakage has now been associated with pulpal inflammation and tooth hypersensitivity (Brannstrom and Nyborg, 1971;Hansen and Bruun, 1971;Browne et al, 1983; for review, see Bergenholtz, 1989), extensive research has been initiated in recent years to develop permanent restorative materials that will seal cavity preparations and prevent marginal leakage.…”

Section: Introductionmentioning

confidence: 99%

“…Since marginal leakage has now been associated with pulpal inflammation and tooth hypersensitivity (Brannstrom and Nyborg, 1971;Hansen and Bruun, 1971;Browne et al, 1983; for review, see Bergenholtz, 1989), extensive research has been initiated in recent years to develop permanent restorative materials that will seal cavity preparations and prevent marginal leakage. GLUMA Dentin Bond is described as a dentin bonding agent that contains 5% w/w glutaraldehyde in a solution of 35% betahydroxyethyl methacrylate (Munksgaard and Asmussen, 1984).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Bacterial Growth under Composite Restorations Following GLUMA Pretreatment

1989

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The purpose of this investigation was to test in five adult monkeys the effects of a glutaraldehyde-containing dentin bonding agent, GLUMA, on bacterial colonization in Class V cavities restored with composite resin. Experimental groups consisted of immediate placement of GLUMA and composite resin as well as placement of GLUMA or Scotchbond (control) in acid-etched cavities that had been left open to the oral environment for 48 hours. Various procedures for pretreatment of the cavities were included. Tissue specimens were prepared for light microscopy for observation of bacterial presence and pulp tissue reactions after eight days and 90 days. Bacteria were not detected in any of the 54 cavities treated with GLUMA regardless of observation period or use of enamel-etching procedure prior to placement of composite resin. When cavities were restored with composite resin without prior GLUMA pretreatment or with Scotchbond, bacteria were present under the majority of restorations at both time intervals. Pulpal inflammation of varying extent and character was seen after eight days in teeth that had been previously infected. At 90 days, pulps showed repair and healing regardless of treatment protocol. Data indicate that GLUMA has a distinct in vivo antibacterial effect that seems to prevent bacterial growth in tooth/restoration interfaces.

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Bacterial microleakage and pulpal inflammation in experimental cavities

Cited by 59 publications

References 22 publications

Microleakage of Three Cement Bases

Microleakage of Three Cement Bases

An enzyme histochemical study of the influence of formocresol and calcium hydroxide on the dental pulp

Inhibition of Bacterial Growth under Composite Restorations Following GLUMA Pretreatment

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