Bacterial metabolism as responsible of beneficial effects of phytoestrogens on human health

Peirotén, Ángela; Bravo, Daniel; Landete, José María

doi:10.1080/10408398.2019.1622505

Cited by 41 publications

(32 citation statements)

References 156 publications

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“…For example, it is well known that differences in the composition of gut microbiota can affect lignan biotransformation in the gut, as reviewed by Peirotén et al. (2020). This is especially relevant to the nonextractable polyphenols that reach colon.…”

Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

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Seeds play important roles in human nutrition and health since ancient time. The term “specialty” has recently been applied to seeds to describe high‐value and/or uncommon food products. Since then, numerous studies have been conducted to identify various classes of bioactive compounds, including polyphenols in specialty seeds. This review discusses nutrients, fat‐soluble bioactives, polyphenols/bioactives, antioxidant activity, bioavailability, health benefits, and safety/toxicology of commonly consumed eight specialty seeds, namely, black cumin, chia, hemp, flax, perilla, pumpkin, quinoa, and sesame. Scientific results from the existing literature published over the last decade have been compiled and discussed. These specialty seeds, having numerous fat‐soluble bioactives and polyphenols, together with their corresponding antioxidant activities, have increasingly been consumed. Hence, these specialty seeds can be considered as a valuable source of dietary supplements and functional foods due to their health‐promoting bioactive components, polyphenols, and corresponding antioxidant activities. The phytochemicals from these specialty seeds demonstrate bioavailability in humans with promising health benefits. Additional long‐term and well‐design human intervention trials are required to ascertain the health‐promoting properties of these specialty seeds.

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Section: Bioavailability Of Nutrients and Bioactives From Specialty Seedsmentioning

confidence: 99%

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Alasalvar

Chang

Bolling

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…Indeed, microbes that reside in the human gut form a co-metabolism structure with the host to participate in various metabolic processes, including biotransformation of food substances[ 2 ]. There is increasing evidence of the involvement of gut microbiota on the health-beneficial effects of food[ 3 ]. Given this, microbial metabolites have recently been profoundly studied in phytopharmacology as potential sources of novel therapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of UA in rodent colon, intestinal, prostate and even brain tissues has been reported, whereas UA glucuronide was primarily detected in liver and kidney tissues[ 7 , 15 , 16 ]. UA has been demonstrated both in in vitro and in vivo experiments to possess a broad spectrum of bioactivities, including antioxidative, anti-inflammatory, antiproliferative and apoptosis-inducing that might contribute to potential cancer chemoprotection (reviewed in[ 3 ]). Since bioavailability of urolithins and their anti-inflammatory, antioxidant and antiproliferative properties are higher relative to parent compounds, the biological activity of EA and ETs including their chemopreventive and chemotherapeutic effects, have been suggested to be mediated by these metabolites[ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection

Kujawska

Jodynis‐Liebert

2020

WJG

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Urolithin A (UA) is a metabolic compound generated during the biotransformation of ellagitannins by the intestinal bacteria. The physiologically relevant micromolar concentrations of UA, achieved in the plasma and gastrointestinal tract (GI) after consumption of its dietary precursors, have been revealed to offer GI protection. The health benefit has been demonstrated to be principally related to anticancer and anti-inflammatory effects. UA has been shown to possess the capability to regulate multiple tumor and inflammatory signaling pathways and to modulate enzyme activity, including those involved in carcinogen biotransformation and antioxidant defense. The purpose of this review is to gather evidence from both in vitro and in vivo studies showing the potential of UA in GI protection alongside suggested mechanisms by which UA can protect against cancer and inflammatory diseases of the digestive tract. The data presented herein, covering both studies on the pure compound and in vivo generated UA form its natural precursor, support the potential of this metabolite in treatment interventions against GI ailments.

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“…Conversely, others have reported that it is the induction of Bifidobacterium pseudocatenulatum by urolithin A that is required for its production (Gaya, Peirotén, Medina, Álvarez, & Landete, 2018). The beneficial findings of Urolithin A are not surprising in regards to its anticancer effects, as a number of groups have demonstrated its antiinflammatory and anti-oxidative properties, more so than urolithin B F I G U R E 1 Hypothesized use of BRB or their products to improve outcomes in cancer therapy (Peirotén, Bravo, & Landete, 2019). Additionally, urolithin A has been shown to directly induce apoptosis via its ability to activate caspase activity in colon cancer cells in vitro .…”

Section: Modulation Of Human Microbiome By Brb Metabolitesmentioning

confidence: 99%

Modulation of the host microbiome by black raspberries or their components and the therapeutic implications in cancer

Peiffer

2020

Food Frontiers

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Black raspberries (BRB) and their components have been demonstrated to prevent and inhibit the progression of cancers including oral, breast, esophageal, and colon in both preclinical studies and human clinical trials. The mechanism for their anticancer effect appears to vary by organ system, and include their anti-inflammatory, antiproliferative, antiangiogenic, and pro-apoptotic properties. Given findings that suggest that the host microbiome plays a distinct role in the development and progression of cancer, there has been a recent focus on discerning if BRB and their constituents modulate gut microbe levels. This review summarizes the reported effects BRB and their constituents have on the human microbiome and the implications that this has for their use in conjunction with traditional chemotherapies. BRB and their components have been shown to modulate the human gut flora in a positive manner, namely by promoting the population of the gut with "good" bacteria. These include BRB, their major polyphenol anthocyanins (AC), the major metabolite of AC protocatechuic acid (PCA), ellagic acid, and its major metabolite the urolithins. All of these components have been shown to modulate the gut flora, with variations between the individual components. This is in comparison to chemotherapeutic drugs including platinum-based entities and 5-flourouracil, which have been reported to negatively impact the human microbiome, leading to dysbiosis. Given these parallel findings, recent studies have attempted to discern if BRB or their components may reverse the negative effects traditional chemotherapies have on the gut microbiome, and if this results in an improvement in therapeutic outcomes.

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Bacterial metabolism as responsible of beneficial effects of phytoestrogens on human health

Cited by 41 publications

References 156 publications

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review

Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection

Modulation of the host microbiome by black raspberries or their components and the therapeutic implications in cancer

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