Bacterial Metabolic Fitness During Pathogenesis

Pandey, Saurabh; Shukla, Nidhi; Singh, Sanjai; Tripathi, Deeksha; Tripathi, Takshashila; Kant, Sashi

doi:10.1007/978-981-15-3028-9_12

Cited by 2 publications

(4 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…Like immune cells, bacterial pathogens can shift metabolism upon encountering the innate immune system, suggesting metabolic changes may reflect a physiological adaptation of the pathogen that can also modulate the immune response and promote bacterial survival [10, 11]. Bacterial metabolic adaptations are often driven by horizontal gene transfer events that improve microbial sensing of environmental cues and promote enhanced regulation of metabolic pathways, especially in fluctuating conditions [10]. This evolutionary process has allowed several bacterial pathogens to develop a broader repertoire of mechanisms to obtain vital nutrients like transition metals, glucose, free peptides, and lipoic acid compared to nonpathogenic bacteria [10, 12, 13].…”

Section: Introductionmentioning

confidence: 99%

“…Bacterial metabolic adaptations are often driven by horizontal gene transfer events that improve microbial sensing of environmental cues and promote enhanced regulation of metabolic pathways, especially in fluctuating conditions [10]. This evolutionary process has allowed several bacterial pathogens to develop a broader repertoire of mechanisms to obtain vital nutrients like transition metals, glucose, free peptides, and lipoic acid compared to nonpathogenic bacteria [10, 12, 13]. Furthermore, some bacterial pathogens possess remarkable mechanisms to detect and respond to oxygen levels within the host, switching between respiration and fermentation as needed [10, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

“…This evolutionary process has allowed several bacterial pathogens to develop a broader repertoire of mechanisms to obtain vital nutrients like transition metals, glucose, free peptides, and lipoic acid compared to nonpathogenic bacteria [10, 12, 13]. Furthermore, some bacterial pathogens possess remarkable mechanisms to detect and respond to oxygen levels within the host, switching between respiration and fermentation as needed [10, 14, 15]. Thus, many bacterial pathogens have a flexible metabolism, which helps overcome nutrient limitations within the human body and evade immune defenses [9].…”

Section: Introductionmentioning

confidence: 99%

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The Intersection between Bacterial Metabolism and Innate Immunity

Acosta,

Alonzo III

2023

J Innate Immun

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Background: The innate immune system is the first line of defense against microbial pathogens and is essential for maintaining good health. If pathogens breach innate barriers, the likelihood of infection is significantly increased. Many bacterial pathogens pose a threat to human health on account of their ability to evade innate immunity and survive in growth-restricted environments. These pathogens have evolved sophisticated strategies to obtain nutrients as well as manipulate innate immune responses, resulting in disease or chronic infection. Summary: The relationship between bacterial metabolism and innate immunity is complex. Although aspects of bacterial metabolism can be beneficial to the host, particularly those related to the microbiota and barrier integrity, others can be harmful. Several bacterial pathogens harness metabolism to evade immune responses and persist during infection. The study of these adaptive traits provides insight into the roles of microbial metabolism in pathogenesis that extend beyond energy balance. This review considers recent studies on bacterial metabolic pathways that promote infection by circumventing several facets of the innate immune system. We also discuss relationships between innate immunity and antibiotics and highlight future directions for research in this field. Key Messages: Pathogenic bacteria have a remarkable capacity to harness metabolism to manipulate immune responses and promote pathogenesis. While we are beginning to understand the multifaceted and complex metabolic adaptations that occur during infection, there is still much to uncover with future research.

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Section: Introductionmentioning

confidence: 99%