Bacterial meningitis in children under 15 years of age in Nepal

Abstract

BackgroundBacterial meningitis in children is a life-threatening problem resulting in severe morbidity and mortality. For the prompt initiation of antibacterial therapy, rapid and reliable diagnostic methods are of utmost importance. Therefore, this study was designed to find out the rate of bacterial pathogens of meningitis from suspected cases by performing conventional methods and latex agglutination.MethodsA descriptive type of study was carried out from May 2012 to April 2013. Cerebrospinal fluid (CSF) specimens from 252 suspected cases of meningitis were subjected for Gram staining, bacterial culture and latex agglutination test. The identification of growth of bacteria was done following standard microbiological methods recommended by American Society for Microbiology. Antibiotic sensitivity testing was done by modified Kirby-Bauer disk diffusion method.ResultsFrom the total 252 suspected cases, 7.2 % bacterial meningitis was revealed by Gram staining and culture methods whereas latex agglutination method detected 5.6 %. Gram-negative organisms contributed the majority of the cases (72.2 %) with Haemophilus influenzae as the leading pathogen for meningitis. Overall, 33.3 % mortality rate was found.ConclusionsIn conclusion, a significant rate of bacterial meningitis was found in this study prompting concern for national wide surveillance.

Bacteriological profile of acute bacterial meningitis at a tertiary care hospital of North India

“…1,9,21 The mortality rate was 11% and it was found most commonly in early paediatric age group (0 -2 years) as compared with others studies as shown in Table 4. 16,22,23 …”

Investigation of Bacterial Meningitis Agents from Patients with Suspicion of Non-Neonatal Meningitis by Conventional and Molecular Methods

“…En yaygın olan bakteriyel menenjit etkenlerinin antijenlerinin belirlenmesinde LAT'ın duyarlılı-ğının %50-100 arasında değiştiği bildirilmektedir (8) . Yadhav (29) yaptığı çalışmaya beş yaş altı klinik şüpheli 100 çocuğu dâhil etmiş, akut bakteriyel menenjit tanısı alan olguların (n=24) 21 (%87.5)'inin kültür ile, 17 (%70.8)'sinin Gram boyama ile, sekizinin (%33.3) LAT ile pozitif olduğunu, Gram boyama ve LAT'ın birlikte değerlendirildiğinde, olguların %85'inin tespit edildiğini belirtmiştir.…”

“…Bakteriyel menenjitin etiyolojik tanısı bir saatten daha kısa sürede sonuç-lanan Lateks Aglütinasyon Testi (LAT) ile müm-kün olabilmektedir (8) . Bu test bakteriyel menenjitin hızlı tanısında %50-100 arasında değişen duyarlılığa sahiptir.…”

SpontaneousEscherichia colibacterial meningitis mimicking heatstroke in an adult

“…It has been reported secondary to trauma or neurosurgery, but also as a spontaneous illness 8, 9. E. coli is a frequent pathogen in pediatric bacterial meningitis 1 but is rare in adult forms of the disease 2, 3, 4. E. coli may cause infections of the bloodstream, urinary tract, biliary system, and peritoneal space.…”

“…coli ) is a frequent pathogen in pediatric bacterial meningitis 1, but is rare in adult forms of the disease 2, 3, 4. In general, acute bacterial meningitis is diagnosed based on clinical signs and cerebrospinal fluid (CSF) analysis.…”