Bacterial localisation in the kidney with particular reference to <i>Pseudomonas pyocyanea</i>

Gorrill, R. H.

doi:10.1002/path.1700640417

Cited by 21 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intravenous injection of mice with either M. abscessus or M. fortuitum resulted in gross abscess-like lesions in th-e kidneys, whereas other organs apparently remained free from disease. This organ specificity had previously been noticed with M. fortuitum, P. pyocyanea, and staphylococci (2,5,17). The lesions in the kidneys of mice infected with M. abscessus strain 481 were uniform abscesses similar to those observed by Wells and co-workers (17) and Kushner and associates (5) in animals infected with M. fortuitum.…”

Section: Resultssupporting

confidence: 77%

Comparison of the Pathogenicity for Mice of Mycobacterium fortuitum and Mycobacterium abscessus

Saito

Tasaka

1969

J Bacteriol

View full text Add to dashboard Cite

The pathogenicity for mice of 12 strains of Mycobacterium abscessus was compared with that for 8 strains of M. fortuitum. Both species caused lesions in kidneys and produced "spinning disease" resulting from inner ear infections. No major differences in pathogenicity of these two species were demonstrated. Strain to strain variation was marked, especially with M. abscessus. For example, 1.6 x 106 organisms of strain 11188 of M. abscessus produced death in four of five animals within 42 days, whereas strain 380 of M. abscessus failed to produce any deaths within 42 days. In the case of M. fortuitum, the greatest mortality observed was one of five animals, yet the incidence of spinning disease and kidney disease occurred earlier postinfection than in mice infected with M. abscessus. Histologically, abscess formation by a strain of M. abscessus was greater than by a strain of M. fortuitum, but this difference cannot be interpreted as a species difference.

show abstract

Section: Resultssupporting

confidence: 77%

Comparison of the Pathogenicity for Mice of Mycobacterium fortuitum and Mycobacterium abscessus

Saito

Tasaka

1969

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…The possibility of blood-borne infection with P. aeruginosa is supported by the demonstration of brain infection with the organism in the present study and by the reports of Gorrill (1952) and Ediger et al (1971). The lung seems to uptake more bacteria when an animal suffers from thermal injury (McRipley and Garrison, 1965;Verder and Rosenthal, 1961).…”

Section: Discussionsupporting

confidence: 78%

“…26 MIYAKI et al mental infection with other micro-organisms, or transplantable tumors (Flynn, 1963). P. aeruginosa has also been implicated in rolling disease (Gorrill, 1952;Ediger, Rabstein and Olson, 1971). It has been reported that in humans and animals the intestine may be an important source of Pseudomonas causing infections in other sites (Hammond et al, 1954;Wensinck et al, 1957;Darrell and Wahba, 1964;Shooter et al, 1966;Jellards and Churcher, 1967).…”

Section: Introductionmentioning

confidence: 99%

Pseudomonas Aeruginosa Infections in Rats Fed on Monosodium Glutamate With Observations on the Pseudomonas Flora in Their Intestines

Miyaki

Aibara

Shimizu

et al. 1973

JJMSB

View full text Add to dashboard Cite

SUMMARY : During the exeriments on the biochemical influence of monosodium glutamate on rats, Pseudomonas aeruginosa infections broke out affecting 23 of 95 rats, 45 males and 50 females, after long-term feeding with diets containing 5 to 20 % monosodium glutamate.Of the 23 infected animals, five males and 18 females, two males and 17 females had lesions in the lungs, mainly lung abscesses. Other changes observed were hemorrhagic enteritis, suppurative keratitis, suppurative prostatitis, and cerebellum abscess.Of 23 control rats autopsied, only one male had subcutaneous abscess in the abdominal region. A large number of P. aeruginosa organisms were found in the jejunum of rats with lung infections. P, aeruginosa of two particular pyocine types were most frequently recovered from the lesions and intestines of the diseased rats. The results of pyocine typing suggested auto-infection.The possible relationship between P. aeruginosa infection and MSG feeding, age and sex was discussed.

show abstract

“…Earlier work (Gorrill, 1952) had shown that strains derived from different sorts of lesions were efficient at producing mouse-kidney infection, so it would be possible to compare in this model a number of isolates made from a variety of hospital infections.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Virulence of Hospital Strains of Pseudomonas aeruginosa

Klyhn¹,

Gorrill²

1967

Journal of General Microbiology

Self Cite

View full text Add to dashboard Cite

SUMMARYThe virulence of 36 strains of Pseudomonas aeruginosa was studied by intravenous injection into mice; the strains were found to fall into three broad groups, of high, medium and low virulence. This difference could not be related to any biochemical property studied, pyocine type nor antibiotic sensitivity pattern. It was found that 24 of the 30 strains of the high and medium virulence group produced large colonies on agar while 5 of the 6 strains of the low virulence group produced small colonies when plated under similar conditions. To test this observation a further series was collected and the strains were allocated to the high or low virulence category on colonial appearance. Mouse challenge with these fresh strains showed that the prediction was accurate. The large colony type had a faster growth rate on agar and in broth than the small. When a strain was grown in agar it was found to be more virulent than when harvested from broth (P = 0.02-0.01).Chromatography studies on slime derived from all three categories showed that they were apparently chemically similar. The amount of slime produced by a standard number of bacteria was measured for agar and broth grown cultures. The yields for the two media were approximately the same with large-colony forms. Small-colony forms produced similar amounts to the large forms on plates, but up to 15 times as much when grown in broth.The ability to kill mice was derived in part from early toxic death; the remainder died of renal disease. Study of the initiation of kidney infection showed that large-colony types were more successful in maintaining their numbers in the kidneys over the first 5 hr. Strains grown on nutrient agar did not give higher counts in the kidney than those from broth in the first 5 hr but after 24 hr they grew faster, infected more kidneys and killed more mice.

show abstract

Bacterial localisation in the kidney with particular reference to Pseudomonas pyocyanea

Cited by 21 publications

References 8 publications

Comparison of the Pathogenicity for Mice of Mycobacterium fortuitum and Mycobacterium abscessus

Comparison of the Pathogenicity for Mice of Mycobacterium fortuitum and Mycobacterium abscessus

Pseudomonas Aeruginosa Infections in Rats Fed on Monosodium Glutamate With Observations on the Pseudomonas Flora in Their Intestines

Studies on the Virulence of Hospital Strains of Pseudomonas aeruginosa

Contact Info

Product

Resources

About