Bacterial interactions with silver

Slawson, Robin M.; Lee, H.; Trevors, J. T.

doi:10.1007/bf01140573

Cited by 110 publications

(82 citation statements)

References 24 publications

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“…Although not investigated in this study, these antibacterial and bactericidal behaviors of Ag ions may result from the following mechanisms: inhibition of DNA replication and mitosis, effects of the permeability of the cell membrane, and control of the oxidation of glucose as reported by other researchers 26) . The antibacterial and bactericidal effects of the Ag ion-coated wires were confirmed in measuring waterinsoluble glucan (WIG), the main component of biofilm formed by cariogenic bacteria.…”

Section: Discussionmentioning

confidence: 98%

Effect of silver ion coating of fixed orthodontic retainers on the growth of oral pathogenic bacteria

et al. 2014

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Titanium and stainless steel wires used for retainers in orthodontic procedures were coated with Ag ions and the effects of the coating on common oral pathogens and their pathogenicity were investigated. Two species of cariogenic and three species of periodontopathic bacteria were assessed. Biofilms of Streptococcus sobrinus and two VSC gases produced by P. gingivalis were also examined. Ag ioncoated wires showed marked antibacterial activities compared with uncoated wires; in most cases, the differences were statistically significant (p<0.05). All Ag ion-coated wires (Ti+ and SS+ wires) displayed more than 2-mm diameter bacteria growth-resistant zones around them in radial diffusion tests. Ag ion release was 0.043±0.005 ppm in 24 h that didn't show cytotoxicity. Thus, these results suggest that a simple Ag ion coating on pure titanium and stainless steel wires can restrict growth and pathogenic activities of oral pathogenic bacteria, even in the early stages of culture.

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Section: Discussionmentioning

confidence: 98%

Effect of silver ion coating of fixed orthodontic retainers on the growth of oral pathogenic bacteria

et al. 2014

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“…24 Thus, it is likely that the mechanisms of AgNP toxicity are similar to those for copper toxicity. Slawson et al 25 reported that Ag + toxicity was reduced when Cu 2+ is also present, indicating that silver may compete with copper for entry into the cell. There appears to be some promiscuity of bacterial metal transport proteins, the functions of which have not been fully elucidated.…”

Section: Disruption Of Oxidative Balancementioning

confidence: 99%

Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action

Nagy

Harrison²,

Sabbani³

et al. 2011

IJN

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Background The focus of this study is on the antibacterial properties of silver nanoparticles embedded within a zeolite membrane (AgNP-ZM). Methods and Results These membranes were effective in killing Escherichia coli and were bacteriostatic against methicillin-resistant Staphylococcus aureus. E. coli suspended in Luria Bertani (LB) broth and isolated from physical contact with the membrane were also killed. Elemental analysis indicated slow release of Ag + from the AgNP-ZM into the LB broth. The E. coli killing efficiency of AgNP-ZM was found to decrease with repeated use, and this was correlated with decreased release of silver ions with each use of the support. Gene expression microarrays revealed upregulation of several antioxidant genes as well as genes coding for metal transport, metal reduction, and ATPase pumps in response to silver ions released from AgNP-ZM. Gene expression of iron transporters was reduced, and increased expression of ferrochelatase was observed. In addition, upregulation of multiple antibiotic resistance genes was demonstrated. The expression levels of multicopper oxidase, glutaredoxin, and thioredoxin decreased with each support use, reflecting the lower amounts of Ag + released from the membrane. The antibacterial mechanism of AgNP-ZM is proposed to be related to the exhaustion of antioxidant capacity. Conclusion These results indicate that AgNP-ZM provide a novel matrix for gradual release of Ag + .

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“…Although the efforts directed towards the biosynthesis of nanomaterials are recent, the interactions between micro-organisms and metals have been well documented (11)(12)(13)(14) and the ability of micro-organisms to extract and/or accumulate metals is employed in commercial biotechnological processes such as bioleaching and bioremediation.…”

Section: Introductionmentioning

confidence: 99%