Bacterial Infections: Bacterial Contamination, Testing, and Post-Transfusion Complications

Ramírez‐Arcos, Sandra; Goldman, Mindy; Blajchman, Morris A.

doi:10.1016/b978-0-443-06981-9.50052-1

Cited by 2 publications

(4 citation statements)

References 101 publications

(146 reference statements)

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“…A donor can develop a short-time bacteremia after dentistry procedures. Staphylococcus aureus was detected in a platelet concentrate collected from a donor two hours after his tooth was treated conservatively (18). Staphylococcus aureus is not the only bacterium that can be the source of blood component contamination.…”

Section: Sources Of Blood Components Bacterial Contaminationmentioning

confidence: 99%

“…Pseudomonades are Gram-negative bacteria commonly found in water and soil. They can proliferate in temperature 4 o C. They often contribute to red blood cell concentrate contamination during concentrate preparation (18). Serratia marcescens was a causative factor in transfusion-associated sepsis reported in Denmark and Sweden, where bacterially contaminated containers were used at blood donations (19).…”

Section: Bacterial Infections Transmitted With Red Blood Cell Concentmentioning

confidence: 99%

“…Thus, such donors are a potential source of blood component contamination (40,41). Transfusion associated bacterial sepsis may be caused by other intestinal pathogens, such as Campylobacter jejuni and Salmonella Heidelberg, which induce donor's bacteremia (18). They damage the intestinal mucosa and move into blood.…”

Section: Sources Of Blood Components Bacterial Contaminationmentioning

confidence: 99%

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Transfusion-Associated Bacterial Sepsis

Korsak¹

2012

Severe Sepsis and Septic Shock - Understanding a Serious Killer

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Section: Sources Of Blood Components Bacterial Contaminationmentioning

confidence: 99%

Section: Bacterial Infections Transmitted With Red Blood Cell Concentmentioning

confidence: 99%

Section: Sources Of Blood Components Bacterial Contaminationmentioning

confidence: 99%

See 1 more Smart Citation

Transfusion-Associated Bacterial Sepsis

Korsak¹

2012

Severe Sepsis and Septic Shock - Understanding a Serious Killer

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“…17,18 Though rare, these infectious transfusion adverse events are driven by the proliferation of contaminating bacteria in PCs, which is promoted by the storage conditions (20-24°C, agitation, neutral pH, in gas permeable containers) used to maintain platelet quality and functionality. 19,20 At Canadian Blood Services and other blood centers, several strategies have been implemented to mitigate this risk 21 ; however, occasionally, bacterially contaminated PCs are transfused into vulnerable patients leading to septic reactions. 17 Cutibacterium acnes is an anaerobic, aerotolerant member of the skin flora and is the most isolated bacterial contaminant of PCs ($70%).…”

Section: Introductionmentioning

confidence: 99%

Cutibacterium acnes contamination does not enhance the proinflammatory profile of platelet concentrates

Kumaran,

Ramirez‐Arcos

2024

Transfusion

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BackgroundCutibacterium acnes, a common anaerobic platelet concentrate (PC) contaminant, has been associated with rare mild adverse transfusion reactions and is often considered a harmless commensal. Notably, C. acnes can cause chronic infections and has been shown to induce the release of proinflammatory cytokines by immune cells. Since elevated concentrations of proinflammatory factors in PCs have been linked to noninfectious adverse reactions, this study aimed to assess whether C. acnes could elicit the release and accumulation of proinflammatory factors during PC storage, thereby enhancing the risk of such reactions.Study Design/MethodsFour ABO‐matched buffy coat PCs were pooled and split into six units, each were inoculated with either saline (negative control), a Staphylococcus aureus isolate (positive control, 30 colony forming units [CFU]/unit), or four C. acnes PC isolates (10 CFU/mL) and stored at 20–24°C with agitation. Bacterial counts, platelet activation, and concentration of proinflammatory factors were assessed on days 0, 3, and 5. N = 3.ResultsC. acnes counts remained stable, while S. aureus proliferated reaching 108CFU/mL by the end of PC storage. By day 5, no significant differences in platelet activation or proinflammatory cytokine profiles were observed in C. acnes‐contaminated PCs compared to the negative control (p > .05), while there was a significant increase (p ≤ .05) in sCD40L concentration (day 3), and platelet activation and IL‐8 concentration (day 5) in S. aureus‐contaminated units.DiscussionC. acnes contamination does not promote the accumulation of proinflammatory factors in the absence of proliferation during storage and may not enhance the risk of inflammatory reactions when transfused to patients.

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Bacterial Infections: Bacterial Contamination, Testing, and Post-Transfusion Complications

Cited by 2 publications

References 101 publications

Transfusion-Associated Bacterial Sepsis

Transfusion-Associated Bacterial Sepsis

Cutibacterium acnes contamination does not enhance the proinflammatory profile of platelet concentrates

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