Bacterial Infections and Clinical Outcomes Among Febrile Infants up to 90 Days Old With SARS-CoV-2 Infection: A Multicenter Cohort Study

Jacob, Ron; Padeh, Gabi; Kaplan, Or; Koppel, Jordanna H.; Porat, Danit; Weiser, Giora; Levy, Nitai; Cohen, Noy; Capua, Tali; Schnapp, Zeev; Friedman, Nir

doi:10.1097/inf.0000000000004019

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…A small patient series of infants admitted to the hospital reported that two of 18 patients had a secondary late bacterial infection [ 26 ]. For infants seen in emergency departments, secondary bacterial infections were not detected in any patient at the same time or bacterial infections were not seemingly secondary as COVID-19-related complications [ 53 , 81 , 133 ]. A similar study reported no significant difference in frequency of secondary infections when infants presented with versus without COVID-19 [ 60 ].…”

Section: Controversy Regarding Infantsmentioning

confidence: 99%

COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Infants aged <1 year represent a seemingly more susceptible pediatric subset for infections. Despite this, coronavirus disease 2019 (COVID-19) infection has not been proven as more serious in this age group (outside the very early neonatal period) than in others. Indeed, a considerable number of asymptomatic infections have been recorded, and the symptoms and morbidity associated with COVID- 19 differ minimally from those of other respiratory viral infections. Whether due to an abundance of caution or truly reduced susceptibility, infections in infants have not raised the same profile as those in other age groups. In addition to direct severe acute respiratory syndrome coronavirus 2 diagnostic tests, laboratory markers that differentiate COVID-19 from other viral infections lack specificity in infants. Gastrointestinal presentations are common, and the neurological complications of infection mirror those of other respiratory viral infections. There have been relatively few reports of infant deaths. Under appropriate precautions, breastfeeding in the context of maternal infections has been associated with tangible but infrequent complications. Vaccination during pregnancy provides protection against infection in infants, at least in the early months of life. Multi-inflammatory syndrome in children and multi-inflammatory syndrome in neonates are commonly cited as variants of COVID-19; however, their clinical definitions remain controversial. Similarly, reliable definitions of long COVID in the infant group are controversial. This narrative review examines the key clinical and laboratory features of COVID-19 in infants and identifies several areas of science awaiting further clarification.

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Section: Controversy Regarding Infantsmentioning

confidence: 99%

COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022

Demey,

Bruyneel,

Chatzis

et al. 2024

Pediatric Infectious Disease Journal

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Our study aimed to assess the severity of severe acute respiratory syndrome coronavirus 2 infection in hospitalized infants under 40 days old, across 21 Belgian hospitals between 2020 and 2022. Of the 365 infants studied, 14.2% needed respiratory support. The median hospital stay was 3 days (interquartile range, 2–4), and there were no deaths. Infection severity was similar during the Omicron and Alpha/Delta periods.

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Bacterial Infections and Clinical Outcomes Among Febrile Infants up to 90 Days Old With SARS-CoV-2 Infection: A Multicenter Cohort Study

Cited by 2 publications

References 8 publications

COVID-19 among infants: key clinical features and remaining controversies

COVID-19 among infants: key clinical features and remaining controversies

SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022

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