Bacterial Infection of Burn Patients and Their Drug-resistance in South Jiangsu China During 2012-2016

Abstract

Objective: Burn infection is the main cause of morbidity and mortality among burn patients; thus, the control of this type of disease is very important to decrease nosocomial infections. Many opportunistic pathogens are not directly involved in the infection of burn patients, but the drug resistance of these pathogens has been changing worldwide. Methods: In this study, we retrospectively analysed the main bacteria and their drug-resistance that caused infection in burn patients in South Jiangsu China during 2012-2016 by using WHONET 5.6 software, Automatic instrument (France BIOMERIEUX Vitek 2 Compact 30) and SPSS 19.0 software. Results: The results revealed that 5329 strains were significantly isolated during the five years with Gram-negative bacteria, Grampositive bacteria, and fungi accounting for 65.47%, 32.17% and 2.36% of the isolated strains, respectively. The top 3 predominant pathogens of these isolated strains were Staphylococcus aureus (23.29%), Pseudomonas aeruginosa (20.25%), and Acinetobacter baumannii (19.70%). In addition, among these bacteria, we found P. aeruginosa showed the highest drug resistance to Cefoperazone/Sulbactam, Imipenem, Levofloxacin, and Piperacillin/Tazobactam in 2014. Acinetobacter baumannii had the highest drug resistance to Ceftriaxone, Cefoperazone/Sulbactam, Imipenem, and Piperacillin/Tazobactam in 2014. S. aureus showed the highest drug resistance to Oxacillin in 2014. Conclusion: In total, our data showed that the majority of bacteria infecting burn patients included S. aureus, P. Aeruginosa, and A. baumannii, and their drug resistance for some antibiotics is increasing, which is valuable information for both the prevention and treatment of infection caused by these bacteria.