Bacterial Immunotherapy-Antitumoral Potential of the Streptococcal Toxin Streptolysin S-

Maletzki, Claudia; Kreikemeyer, Bernd; Bodammer, Peggy; Emmrich, Joerg; Linnebacher, Michael

doi:10.5772/28730

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Then Coley tried to treat tumors with inactivated bacteria, such as S. pyogenes and Serrati amarcescens and established the foundation of bacterial therapies on cancer (Richardson et al, 1999). In recent years, people find various bacteria with good tumor-targeting property, including Salmonella (Pawelek et al, 1997), Escherichia, Clostridium (Malmgren and Flanigan, 1955;Minton, 2003), Bifidobacterium (Kohwi et al, 1978), Caulobacter, Listeria (Pan et al, 1999;Kim et al, 2009), Proteus (Arakawa et al, 1968), and Streptococcus (Maletzki et al, 2008). Caulobacter crescentus (C. crescentus) as a Gram-negative non-pathogenic bacterium presented tumor suppressive effects in unmodified form (Bhatnagar et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Coating bacteria for anti-tumor therapy

Wang

Guo

Hou

et al. 2022

Front. Bioeng. Biotechnol.

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Therapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-medicated antitumor therapy has been successfully applied on mouse models, but the low therapeutic effect and biosafe limit its application on clinical treatment. With the development of material science, coating living bacteria with suitable materials has received widespread attention to achieve synergetic therapy on tumor. In this review, we summarize various materials for coating living bacteria in cancer therapy and envision the opportunities and challenges of bacteria-medicated antitumor therapy.

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