Bacterial flora in psoriasis

Aly, Raza; Maibach, Howard I.; Mandel, Adrian D.

doi:10.1111/j.1365-2133.1976.tb07031.x

Cited by 66 publications

(31 citation statements)

References 12 publications

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“…The percentage of patients carrying S. aureus on psoriatic plaques was found to be 30% by ALY et al (1976). This is an intermediate between previous estimates of 50% and 26%, but certainly higher than the carriage rate in their control population.…”

Section: Psoriasiscontrasting

confidence: 59%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

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PrefaceThe recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology.We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.It was because of this burgeoning interest in pharmacology of skin and its diseases, that this book came about. Indeed it is long overdue and was planned several years ago; we console ourselves with the thought that the delay may have served to help define certain principles which were then only just emerging.The book is divided into two volumes which are independent but complementary; the first being an account of the general pharmacology of skin, the second volume being more concerned with disease and drugs. The first volume is divided into two parts, the one dealing with the pharmacology of skin systems and their control and the other with autocoids in normal and inflamed skin. This second volume has three parts; the first part deals with the methods of measurement which are becoming of increasing importance both in studying the pharmacological effects of drugs and the clinical pharmacology of skin; the second deals with toxicology in its widest sense -including metabolism and percutaneous absorption; and the third is an account both of specific drugs and the drugs used for specific diseases.

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Section: Psoriasiscontrasting

confidence: 59%

Pharmacology of the Skin II

1989

Handbook of Experimental Pharmacology

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“…Our results demonstrated no down‐regulation of TGF‐β1 in psoriasis compared to normal skin with a significant positive correlation between levels of TGF‐β1 in psoriatic plaques and serum, suggesting that the mechanisms for TGF‐β1 production and release in both these compartments may be related. The discrepancy in reported results among investigators may be explained by: (a) in psoriasis, TGF‐β1–related lack of growth regulation could be either due to down regulation of TGF‐β1 expression in psoriatic skin and/or down regulation of TGF‐β1 receptors in the skin; 8,16 (b) TGF‐β1 is primarily located in the stratum corneum and the granular layer of epidermis, the latter is diminished in older lesions of psoriasis 17 thus lesion's age may be an important determinant factor for TGF‐β1 levels in psoriasis (in this study, we selected most recent developing psoriatic plaques in the patient to examine); (c) different methods of detection of TGF‐β1 in these studies (d) detection of TGF‐β1 in scales is not the best accurate way for measurement of this protein 9 …”

Section: Discussionmentioning

confidence: 96%

Serum and tissue expression of transforming growth factor beta 1 in psoriasis

Zaher¹,

Shaker²,

El-Komy³

et al. 2009

Acad Dermatol Venereol

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“…Xenograft models of psoriasis, in which unaffected skin from psoriasis patients was grafted on immunodeficient mice, showed that stimulation with bacterial antigen could trigger the skin to become lesional (Boehncke et al 1996). Early culture-based studies examining microorganisms associated with psoriasis identified Malassezia, group A and B b-hemolytic streptococci, S. aureus, and Enterococcus faecalis (Aly et al 1976;Rosenberg et al 1994;Nickoloff et al 2000). Culture-independent analysis of fungal microbiota found no conclusive evidence to link Malassezia with psoriasis (Paulino et al 2006(Paulino et al , 2008.…”

Section: Psoriasismentioning

confidence: 99%

Microbial Ecology of the Skin in the Era of Metagenomics and Molecular Microbiology

Hannigan

Grice

2013

Cold Spring Harbor Perspectives in Medicine

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The skin is the primary physical barrier between the body and the external environment and is also a substrate for the colonization of numerous microbes. Previously, dermatological microbiology research was dominated by culture-based techniques, but significant advances in genomic technologies have enabled the development of less-biased, cultureindependent approaches to characterize skin microbial communities. These molecular microbiology approaches illustrate the great diversity of microbiota colonizing the skin and highlight unique features such as site specificity, temporal dynamics, and interpersonal variation. Disruptions in skin commensal microbiota are associated with the progression of many dermatological diseases. A greater understanding of how skin microbes interact with each other and with their host, and how we can therapeutically manipulate those interactions, will provide powerful tools for treating and preventing dermatological disease.

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Bacterial flora in psoriasis

Cited by 66 publications

References 12 publications

Pharmacology of the Skin II

Pharmacology of the Skin II

Serum and tissue expression of transforming growth factor beta 1 in psoriasis

Microbial Ecology of the Skin in the Era of Metagenomics and Molecular Microbiology

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