Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives

Liu, Han; Zhang, Qin; Wang, Sicheng; Weng, Weizong; Jing, Yingying; Su, Jiacan

doi:10.1016/j.bioactmat.2021.12.006

Cited by 91 publications

(88 citation statements)

References 166 publications

(227 reference statements)

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“…There has been an evaluation of the application validity in the fermentation industry by using immobilized enzymes altering different parameters in the case of some food items [ 143 , 144 ]. Over the past decade, there has been an emergent interest due to the great potential such as its gelling behavior and high specific surface area in the use of BC as functional materials in bioprocessing technologies, including the delivery system of bioactive agents [ 27 , 145 ]. A number of studies on the delivery and loading of diverse bioactive agents by BC have been reported recently.…”

Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

Choi

Rao

et al. 2022

Polymers

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The sharp increase in the use of cellulose seems to be in increasing demand in wood; much more research related to sustainable or alternative materials is necessary as a lot of the arable land and natural resources use is unsustainable. In accordance, attention has focused on bacterial cellulose as a new functional material. It possesses a three-dimensional, gelatinous structure consisting of cellulose with mechanical and thermal properties. Moreover, while a plant-originated cellulose is composed of cellulose, hemi-cellulose, and lignin, bacterial cellulose attributable to the composition of a pure cellulose nanofiber mesh spun is not necessary in the elimination of other components. Moreover, due to its hydrophilic nature caused by binding water, consequently being a hydrogel as well as biocompatibility, it has only not only used in medical fields including artificial skin, cartilage, vessel, and wound dressing, but also in delivery; some products have even been commercialized. In addition, it is widely used in various technologies including food, paper, textile, electronic and electrical applications, and is being considered as a highly versatile green material with tremendous potential. However, many efforts have been conducted for the evolution of novel and sophisticated materials with environmental affinity, which accompany the empowerment and enhancement of specific properties. In this review article, we summarized only industry and research status regarding BC and contemplated its potential in the use of BC.

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Section: Applicationsmentioning

confidence: 99%

Bacterial Cellulose and Its Applications

Choi

Rao

et al. 2022

Polymers

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“…Due to their unique physicochemical properties, including an ultra-small size, a large surface area and loading ability, nanomaterials have overcome many limitations of conventional therapeutic and diagnostic strategies ( Dong et al, 2020 ). The key of nanomedicine development is to improve the specific recognition ability for disease tissues ( Liu et al, 2021 ). The combination of aptamers and nanomaterials is a promising progress for targeted drug delivery ( Figure 1 ) ( Mahmoudpoura et al, 2021 ).…”

Section: Aptamer-based Nanomaterials System For Targeted Drug Deliverymentioning

confidence: 99%

Recent advances in aptamer-based targeted drug delivery systems for cancer therapy

Gao

Yin

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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The past decade has become an important strategy in precision medicine for the targeted therapy of many diseases, expecially various types of cancer. As a promising targeted element, nucleic acid aptamers are single-stranded functional oligonucleotides which have specific abilities to bind with various target molecules ranging from small molecules to entire organisms. They are often named ‘chemical antibody’ and have aroused extensive interest in diverse clinical studies on account of their advantages, such as considerable biostability, versatile chemical modification, low immunogenicity and quick tissue penetration. Thus, aptamer-embedded drug delivery systems offer an unprecedented opportunity in bioanalysis and biomedicine. In this short review, we endeavor to discuss the recent advances in aptamer-based targeted drug delivery platforms for cancer therapy. Some perspectives on the advantages, challenges and opportunities are also presented.

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“…Proteomics analysis implied that MVs from different bacterial sources were diverse in composition (Williams et al, 2007 ; Choi et al, 2011 ; Lee et al, 2015 ), indicating that various bacterial infections caused different inflammatory responses. The selectivity of MV cargo seems a deliberate process, rather than a random event, though the biogenesis mechanism of cargo selection is still ambiguous (Liu et al, 2022 ). The biogenesis of MVs is supposed to be regulated by multiple elements, including genetic background and growth conditions such as temperature, stress factors, oxidation state, iron, vasculogenesis, and immune response regulators (VirRs) (Jan, 2017 ; Furuyama and Sircili, 2021 ; Palacios et al, 2021 ).…”

Section: Biogenesis and Composition Of Evsmentioning

confidence: 99%

Extracellular vesicle-mediated regulation of macrophage polarization in bacterial infections

Zhu

Zhang

2022

Front. Microbiol.

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Extracellular vesicles (EVs) are nanoscale membrane-enveloped vesicles secreted by prokaryotic and eukaryotic cells, which are commonly defined as membrane vesicles (MVs) and exosomes, respectively. They play critical roles in the bacteria–bacteria and bacteria–host interactions. In infectious diseases caused by bacteria, as the first line of defense against pathogens, the macrophage polarization mode commonly determines the success or failure of the host's response to pathogen aggression. M1-type macrophages secrete pro-inflammatory factors that support microbicidal activity, while alternative M2-type macrophages secrete anti-inflammatory factors that perform an antimicrobial immune response but partially allow pathogens to replicate and survive intracellularly. Membrane vesicles (MVs) released from bacteria as a distinctive secretion system can carry various components, including bacterial effectors, nucleic acids, or lipids to modulate macrophage polarization in host–pathogen interaction. Similar to MVs, bacteria-infected macrophages can secrete exosomes containing a variety of components to manipulate the phenotypic polarization of “bystander” macrophages nearby or long distance to differentiate into type M1 or M2 to regulate the course of inflammation. Exosomes can also repair tissue damage associated with the infection by upregulating the levels of anti-inflammatory factors, downregulating the pro-inflammatory factors, and regulating cellular biological behaviors. The study of the mechanisms by which EVs modulate macrophage polarization has opened new frontiers in delineating the molecular machinery involved in bacterial pathogenesis and challenges in providing new strategies for diagnosis and therapy.

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Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives

Cited by 91 publications

References 166 publications

Bacterial Cellulose and Its Applications

Bacterial Cellulose and Its Applications

Recent advances in aptamer-based targeted drug delivery systems for cancer therapy

Extracellular vesicle-mediated regulation of macrophage polarization in bacterial infections

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