Bacterial exopolysaccharides in drug delivery applications

Saha, Ishika; Datta, Sriparna

doi:10.1016/j.jddst.2022.103557

Cited by 13 publications

(6 citation statements)

References 155 publications

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“…EPSs can contribute to stabilizing nanoparticles in a colloidal state and reducing metal content [172]. Additionally, EPS-tagged drugs are easily delivered to the appropriate target sites, simply adhering to the mucosal surfaces, resulting in the drug reaching and reacting with them [173].…”

Section: The Potential Applications Of Cyanobacterial Eps In the Phar...mentioning

confidence: 99%

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Manoharan,

Natesan,

Billamboz

et al. 2024

Applied Microbiology

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Instances of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, are rapidly increasing in western and newly industrialized countries. Exopolysaccharides (EPSs) are one of the strategies to enhance the gut microbiota and modulate the immune-inflammatory response deregulation in IBD patients. EPSs are produced by commensal bacteria such as Lactobacillus and Bifidobacterium. Additionally, Cyanobacteria species are promising sources of novel EPS and have potential pharmaceutical and therapeutic applications. The presence of uronic acids and sulphate groups in Cyanobacterial EPSs is an important factor that gives EPSs an anionic charge that is not seen in other prokaryotic species. This feature may impact their physico-chemical characteristics and biological properties. Additionally, Cyanobacterial EPSs have a wide range of biotechnological applications that include use as thickeners, stabilizers, and gelling agents in the food and pharmaceutical sectors. The present review focuses on the role of EPSs in IBD, with a special focus on EPSs derived from Cyanobacteria. This review also covers the biological properties of Cyanobacterial EPS in immuno-inflammatory responses and against pathogens as well as its role in biotechnological applications. Overall, Cyanobacterial EPSs have therapeutic potential against IBD due to their anti-inflammatory and immunoregulatory properties that can reduce inflammation and regulate the immune response and restore the gut microbiota of patients.

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Section: The Potential Applications Of Cyanobacterial Eps In the Phar...mentioning

confidence: 99%

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Manoharan,

Natesan,

Billamboz

et al. 2024

Applied Microbiology

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“…Because of their biocompatibility, biodegradability, and increased physical and biological properties, microbial EPS are being explored as a viable replacement for chemical polymers [ 1 ]. Over the past few decades, a large variety of microbial EPS have been reported with applications in numerous industries, such as food, medicine, pharmaceuticals, petroleum, environmental remediation, and cosmetics [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Xanthan gum is a water-soluble EPS, and it is the earliest bacterial EPS to be produced via aerobic fermentation of simple sugars by Xanthomonas campestris in stirred tank fermenters [ 2 ]. It is also the second microbial EPS to receive FDA approval for use as a thickener and stabilizer in food additives [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Data-driven intelligent modeling, optimization, and global sensitivity analysis of a xanthan gum biosynthesis process

Amenaghawon,

Igemhokhai,

Eshiemogie

et al. 2024

Heliyon

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“…Moreover, EPSs have potential applications in pharmaceuticals, cosmetics, and biotechnology. They can be utilized as encapsulation agents, stabilizers for drug delivery systems, and components in wound healing products [6]. Studies suggest that there are potential health benefits associated with the consumption of probiotic L. mesenteroides exopolysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Immunomodulatory Activity of an Exopolysaccharide Produced by Probiotic Leuconostoc mesenteroides 201607 Isolated from Fermented Food

Vijayalakshmi,

Kim,

Chelliah

et al. 2024

Applied Microbiology

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Fermented foods containing probiotic Leuconostoc mesenteroides 201607 (LM) were used to extract exopolysaccharides. An incomplete understanding exists regarding the immunomodulatory characteristics of exopolysaccharides (EPSs), which are important constituents of bacterial biofilms. In this instance, we examined the immunomodulatory capacity of EPSs from fermented food extracted from L. mesenteroides 201607. Partially purified exopolysaccharide from L. mesenteroides 201607 (PP-LMEPS) consists of glucose (57.1%), rhamnose (29.53%), and galactose (13.36%). The maximum EPS yield was attained after 30 h of incubation at 37 °C and an initial pH of 7.0. When lipopolysaccharide-stimulated RAW264.7 was exposed to PP-LMEPS, the inflammatory cytokines were considerably decreased or elevated dose-dependently. Upon the exposure of lipopolysaccharide-stimulated RAW264.7 cells to PP-LMEPS, a dose-dependent modulation of inflammatory cytokines was observed. This suggests that the extracted EPS possesses immunomodulatory characteristics, as evidenced by a significant decrease or increase in inflammatory cytokine levels. However, further research is warranted to fully elucidate the precise mechanisms and potential therapeutic implications of the immunomodulatory properties of PP-LMEPS.

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Bacterial exopolysaccharides in drug delivery applications

Cited by 13 publications

References 155 publications

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Role of Bacteria-Derived Exopolysaccharides in Inflammatory Bowel Disease with a Special Focus on Cyanobacterial Exopolysaccharides

Data-driven intelligent modeling, optimization, and global sensitivity analysis of a xanthan gum biosynthesis process

Structural Characterization and Immunomodulatory Activity of an Exopolysaccharide Produced by Probiotic Leuconostoc mesenteroides 201607 Isolated from Fermented Food

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