Bacterial disinfection and cell assessment post ultraviolet-C LED exposure for wound treatment

Sheikh, Jahanzeb; Swee, Tan Tian; Saidin, Syafiqah; Yahya, Azli; Malik, Sameen Ahmed; Yin, Joyce Sia Sin; Thye, Matthias Tiong Foh

doi:10.1007/s11517-021-02360-8

Cited by 7 publications

(11 citation statements)

References 23 publications

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“…The SLR's results demonstrate a concentration of studies [3,8,17,[21][22][23][28][29][30][31][32][33][34][35][36][37][38][39][40] in this scientific field. Of these studies, all found some level of decontamination effectiveness.…”

Section: Human Healthmentioning

confidence: 75%

“…Of these studies, all found some level of decontamination effectiveness. In terms of disinfection (at least three log-reduction), we have seven studies [3,24,[33][34][35][36][37][38] indicating it. Meanwhile, ten studies [8,17,21,23,[28][29][30][31][32]39] indicate elimination of biological indicators (sterilization) or growth inhibition.…”

Section: Human Healthmentioning

confidence: 99%

“…The first issue relates to the damage UVC may cause to DNA and its possible toxicity. Although this is a crucial concern, some studies [17,36,37] found no significant results related to neither DNA damage nor cell toxicity. Conversely, these results are dose-dependent when dealing with blood elements [21].…”

Section: Human Healthmentioning

confidence: 99%

“…Gram-negative bacteria were Enterobacter spp. [ [23,34], Legionella pneumophila [32], Pseudomonas aeruginosa [21,22,[28][29][30]34,36,50,57], Pseudomonas alcaligenes [69], Pseudomonas brenneri [54], Raoultella ornithinolytica [54], Salmonella enteritidis [18], Salmonella senftenberg [18], Salmonella tennessee [18], Salmonella typhimurium [1, 6,7,34,43,45,51,56,59,[61][62][63][67][68][69]72], Serratia marcescens [44,46,69], and Vibrio cholerae [57]. Whereas, Gram-positive bacteria were Bacillus anthracis [71], Bacillus atrophaeus [71], Bacillus cereus [56,60], Bacillus pumilus [60], Bacillus subtilis [10], Bacillus spizizenii [67], Enterococcus faecalis [22], Enterococcus faecium [23]<...…”

Section: Bacteriamentioning

confidence: 99%

“…A common approach is the comparison of the decontamination efficacy among representatives of both groups [1, 6,7,10,18,22,23,28,34,36,40,43,44,46,51,54,56,59,61,62,[66][67][68][69]72]. This comparison is important for final users, as they evaluate whether UVC displayed better decontamination rates at one group than at the other, which turned out to be true for Gramnegative for most studies [1, 6,10,18,22,36,43,44,46,51,59,61,62,66,67,72]. Kim et al [1] explain this result by the low appearance of UV products in Gram-positive bacteria.…”

Section: Bacteriamentioning

confidence: 99%

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A Comprehensive Analysis of the UVC LEDs’ Applications and Decontamination Capability

et al. 2022

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The application of light-emitting diodes (LEDs) has been gaining popularity over the last decades. LEDs have advantages compared to traditional light sources in terms of lifecycle, robustness, compactness, flexibility, and the absence of non-hazardous material. Combining these advantages with the possibility of emitting Ultraviolet C (UVC) makes LEDs serious candidates for light sources in decontamination systems. Nevertheless, it is unclear if they present better decontamination effectiveness than traditional mercury vapor lamps. Hence, this research uses a systematic literature review (SLR) to enlighten three aspects: (1) UVC LEDs’ application according to the field, (2) UVC LEDs’ application in terms of different biological indicators, and (3) the decontamination effectiveness of UVC LEDs in comparison to conventional lamps. UVC LEDs have spread across multiple areas, ranging from health applications to wastewater or food decontamination. The UVC LEDs’ decontamination effectiveness is as good as mercury vapor lamps. In some cases, LEDs even provide better results than conventional mercury vapor lamps. However, the increase in the targets’ complexity (e.g., multilayers or thicker individual layers) may reduce the UVC decontamination efficacy. Therefore, UVC LEDs still require considerable optimization. These findings are stimulating for developing industrial or final users’ applications.

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