Bacterial detachment from a wall with a bump line

Yang, Jinyou; Shimogonya, Yuji; Ishikawa, Takuji

doi:10.1103/physreve.99.023104

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…In this quest, detachment of bacterial cells from various surfaces has been studied. 35 − 38 Numerous studies reported that fluid flow can detach adherent bacterial cells from smooth non-textured surfaces. 29 , 36 , 39 − 41 However, adhesion and detachment of bacteria from nanostructured surfaces are less understood.…”

Section: Introductionmentioning

confidence: 99%

Fluid Flow Induces Differential Detachment of Live and Dead Bacterial Cells from Nanostructured Surfaces

2022

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Nanotopographic surfaces are proven to be successful in killing bacterial cells upon contact. This non-chemical bactericidal property has paved an alternative way of fighting bacterial colonization and associated problems, especially the issue of bacteria evolving resistance against antibiotic and antiseptic agents. Recent advancements in nanotopographic bactericidal surfaces have made them suitable for many applications in medical and industrial sectors. The bactericidal effect of nanotopographic surfaces is classically studied under static conditions, but the actual potential applications do have fluid flow in them. In this study, we have studied how fluid flow can affect the adherence of bacterial cells on nanotopographic surfaces. Gram-positive and Gram-negative bacterial species were tested under varying fluid flow rates for their retention and viability after flow exposure. The total number of adherent cells for both species was reduced in the presence of flow, but there was no flowrate dependency. There was a significant reduction in the number of live cells remaining on nanotopographic surfaces with an increasing flowrate for both species. Conversely, we observed a flowrate-independent increase in the number of adherent dead cells. Our results indicated that the presence of flow differentially affected the adherent live and dead bacterial cells on nanotopographic surfaces. This could be because dead bacterial cells were physically pierced by the nano-features, whereas live cells adhered via physiochemical interactions with the surface. Therefore, fluid shear was insufficient to overcome adhesion forces between the surface and dead cells. Furthermore, hydrodynamic forces due to the flow can cause more planktonic and detached live cells to collide with nano-features on the surface, causing more cells to lyse. These results show that nanotopographic surfaces do not have self-cleaning ability as opposed to natural bactericidal nanotopographic surfaces, and nanotopographic surfaces tend to perform better under flow conditions. These findings are highly useful for developing and optimizing nanotopographic surfaces for medical and industrial applications.

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Section: Introductionmentioning

confidence: 99%

Fluid Flow Induces Differential Detachment of Live and Dead Bacterial Cells from Nanostructured Surfaces

2022

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“…There are considerable numbers of studies focusing on microswimmer dynamics near a non-trivial geometrical structures such as curved obstacles [16,46], bumps [18,47] and maze-like micro-devices [9,10], but the lengthscale of the surface topography in the current study features much finer surface structures. We also note that the transitional vertical behaviours in the zdirection, from perturbations of the stable swimming height for a flat wall to topography-following motion at very large surface topography wavelength, necessitates a consideration of a finite-size amplitude of the surface topography.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, motility near surfaces also has a functional role, for instance biofilm formation and initial spread [7], as well as enhanced searching, which in turn is significant for fish egg fertilisation, where sperm need to encounter the egg micropyle [8]. In addition, curved boundaries such as convex walls, corners and obstacles, are easily fabricated in microfluidic devices, which has motivated studies on the effects of such confinements both for biological microorganisms [9][10][11][12][13][14][15][16][17][18] and artificial microswimmers [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Squirmer hydrodynamics near a periodic surface topography

Ishimoto,

Gaffney,

Smith

2021

Preprint

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“…Due to the small size of the Janus particle, we neglect inertial effects in the flow field and assume Stokes flow. A boundary element method was used as in our former study [24]. In the Stokes flow regime, the velocity around the Janus microdimer can be determined by the following boundary integral equation [25]:…”

Section: Basic Equationsmentioning

confidence: 99%

“…A boundary element method was used as in our former study [24]. In the Stokes flow regime, the velocity around the Janus microdimer can be determined by the following boundary integral equation [25]:…”

Section: Basic Equationsmentioning

confidence: 99%

Janus microdimer swimming in an oscillating magnetic field

Yang

2020

R. Soc. open sci.

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Artificial microswimmers powered by magnetic fields have numerous applications, such as drug delivery, biosensing for minimally invasive medicine and environmental remediation. Recently, a Janus microdimer surface walker that can be propelled by an oscillating magnetic field near a surface was reported by Li et al. ( Adv. Funct. Mater. 28 , 1706066. ( doi:10.1002/adfm.201706066 )). To clarify the mechanism for the surface walker, we numerically studied in detail a Janus microdimer swimming near a wall actuated by an oscillating magnetic field. The results showed that a Janus microdimer in an oscillating magnetic field can produce magnetic torque in the y -direction, which eventually propels the Janus microdimer along the x -direction near a wall. Furthermore, we found that the Janus microdimer can also move along a special direction in an oscillating magnetic field with two orientations without a wall. The knowledge obtained in this study is fundamental for understanding the interactions between a Janus microdimer and surfaces in an oscillating magnetic field and is useful for controlling Janus microdimer motion with or without a wall.

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Bacterial detachment from a wall with a bump line

Cited by 9 publications

References 34 publications

Fluid Flow Induces Differential Detachment of Live and Dead Bacterial Cells from Nanostructured Surfaces

Fluid Flow Induces Differential Detachment of Live and Dead Bacterial Cells from Nanostructured Surfaces

Squirmer hydrodynamics near a periodic surface topography

Janus microdimer swimming in an oscillating magnetic field

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