Bacterial culture and antibiotic susceptibility in patients with acute appendicitis

Song, Dae Woon; Park, Byung Kwan; Suh, Sanggyun; Lee, Seung Eun; Kim, Jong Won; Park, Joong-Min; Kim, Hye Ryun; Lee, Mi-Kyung; Choi, Yun-Sang; Kim, Beom Gyu; Park, Yong Gum

doi:10.1007/s00384-018-2992-z

Cited by 29 publications

(48 citation statements)

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“…[22] Common infectious causes of appendicitis have described including Escherichia coli and Pseudomonas aeruginosa . [22,23] In addition, a genome-wide expression analysis study delineated increased mRNA expression of genes associated with neutrophil innate defense systems in acute appendicitis patients. [6] Thus, the increased susceptibility to infection in asthma patients could increase the risk of the infection associated with acute appendicitis.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of appendectomy in patients with asthma

Kim

Park

et al. 2019

Medicine

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Section: Discussionmentioning

confidence: 99%

Increased risk of appendectomy in patients with asthma

Kim

Park

et al. 2019

Medicine

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“…Solo en dos casos (1%) se aisló Pseudomonas aeruginosa , en estudios previos, la frecuencia de esta bacteria es muy variable, en el estudio multicéntrico de Coccolini su frecuencia fue también baja (3,3%) 17 .Sin embargo, otros autores de diferentes latitudes ubican a este microorganismo en un segundo lugar entre los Gram negativos, con proporciones entre el 10 y el 16 % 9 , 15 , 16 , 19 .…”

Section: Discussionunclassified

“…El porcentaje de recuperación de anaerobios (51 %) (n=79) es muy superior a lo reportado, con un rango entre 4,2 % y 20 % 11 , 12 , 14 , 15 . En esta serie, el anaerobio más aislado fue Bacteroides spp., lo cual concuerda con todos los estudios; no obstante, el hallazgo de B. thetaiotaomicron como la especie más frecuente, difiere de lo reportado en otras latitudes.…”

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Recuperación de bacterias aerobias y anaerobias de pacientes con apendicitis aguda mediante botellas de hemocultivo

et al. 2019

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Introduccción. La apendicitis aguda es la primera causa de abdomen agudo; sin embargo, poco se conoce sobre las bacterias asociadas y su perfil de sensibilidad.Objetivo. Identificar y determinar el patrón de resistencia de las bacterias aerobias y anaerobias aisladas en cultivo de líquido periapendicular tomado de los pacientes con apendicitis aguda, y establecer la proporción de bacterias según la fase clínica. Materiales y métodos. Se llevó a cabo un estudio descriptivo y prospectivo en el Hospital Universitario de San José de Bogotá (Colombia), en pacientes mayores de 16 años sometidos a apendicectomía abierta. Se tomaron muestras de líquido periapendicular, las cuales se sembraron directamente en botellas de hemocultivos para aerobios y anaerobios.Resultados. Se incluyeron 154 pacientes. Del total de cultivos, el 87 % (n=134) fueron positivos: 77 % (n=118) para aerobios y 51 % (n=79) para anaerobios. La proporción de cultivos positivos fue inferior en los casos de apendicitis no complicada, en comparación con aquellos de apendicitis complicada (80 % (66/83) Vs. 95 % (67/71); p=0,003). Los microorganismos aislados con mayor frecuencia fueron: Escherichia coli (53 %) (n=84), Bacteroides sp. (25 %) (n=25), Propionibacterium acnes (21 %) (n=21), Staphylococci coagulasa negativo (17 %) (n=27), Enterococcus sp. (10 %) (n=15) y Fusobacterium sp. (11 %) (n=11). La sensibilidad de E. coli a la amplicilina sulbactam fue de 30 %. La sensibilidad de Bacteroides spp. a la clindamicina y la ampicilina sulbactam fue de 91 %. El 100 % de los anaerobios fueron sensibles a piperacilina tazobactam, ertapenem, meropenem y metronidazol.Conclusiones. Los cultivos intraoperatorios son pertinentes en la apendicitis para determinar el patrón epidemiológico local, y establecer los antibióticos profilácticos y terapéuticos para esta enfermedad. Su siembra directa en botellas de hemocultivo permite una gran recuperación de microorganismos.

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“…Conversion to CLA was defined as any additional port insertion during SPLA [10]. The use of antibiotics in our institution was described in a previous study [11].…”

Section: Methodsmentioning

confidence: 99%

Risk factors for additional port insertion in single-port laparoscopic appendectomy.

Choi

Park

Suh

et al. 2018

Videosurgery and Other Miniinvasive Techniques

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Introduction Single-port laparoscopic appendectomy (SPLA) was expected to have reduced risk of wound infection, less postoperative pain, and improved patient’s satisfaction with better cosmesis compared with conventional laparoscopic appendectomy (CLA). When SPLA is converted to CLA, the additional incision for another port insertion can lead to a decrease in the surgical advantages and clinical benefit. Aim To evaluate risk factors for conversion to CLA during SPLA. Material and methods Between August 2015 and December 2016, patients who underwent intended SPLA were retrospectively reviewed. Conversion was defined as any insertion of an additional port, and complicated appendicitis was defined as gangrenous or perforated appendicitis, abscess, or peritonitis in preoperative computed tomography. Postoperative complication was defined as any deviation in the routine postoperative course within 30 days postoperatively. Results Of 409 patients, 65 (15.9%) were treated with additional port insertion. The overall complication rate was 1.5% in each group, of which 1 patient developed superficial SSI and 4 patients developed deep surgical site infections in the SPLA group. After univariable and multivariable analysis, old age, male sex, increased serum C-reactive protein (OR = 2.944; 95% CI: 1.433–6.047; p = 0.003), and complicated appendicitis (OR = 3.330; 95% CI: 1.304–8.503; p = 0.012) were significant risk factors for conversion to CLA. Conclusions The conversion rate to CLA was 15.9%. Serum C-reactive protein level and complicated appendicitis were strong predictive factors for conversion from SPLA in acute appendicitis.

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Bacterial culture and antibiotic susceptibility in patients with acute appendicitis

Abstract: In perforated appendicitis, the use of empirical antibiotics seems to be safe. In some cases of Pseudomonas infection, adequate antibiotics should be considered.

Cited by 29 publications

References 28 publications

Increased risk of appendectomy in patients with asthma

Increased risk of appendectomy in patients with asthma

Recuperación de bacterias aerobias y anaerobias de pacientes con apendicitis aguda mediante botellas de hemocultivo

Risk factors for additional port insertion in single-port laparoscopic appendectomy.

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