Bacterial conversion of CO2 to organic compounds

Choi, Kyeong Rok; Ahn, Yeah-Ji; Lee, Sang Yup

doi:10.1016/j.jcou.2022.101929

Cited by 20 publications

(8 citation statements)

References 69 publications

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“…To date, a variety of natural or artificial SA biosynthesis pathways have been reported, of which four major metabolic pathways are often adopted, as shown in Figure 2 ( Liu et al, 2022 ): 1) reductive TCA cycle; 2) oxidative TCA cycle; 3) the glyoxylate pathway; 4) the 3-hydroxypropionate cycle (3HP cycle) ( Sanchez et al, 2005 ; Ahn et al, 2016 ; Vuoristo et al, 2016 ). The reductive TCA cycle is used by prokaryotes, such as E. coli , to produce SA and utilize CO 2 ( Choi et al, 2022 ). The beneficial effects of CO 2 fixation and SA biosynthesis are reciprocal.…”

Section: Enhanced Co 2 Fixation In Sa Biosynthesismentioning

confidence: 99%

Advances in succinic acid production: the enhancement of CO2 fixation for the carbon sequestration benefits

Lin,

Li,

Wang

et al. 2024

Front. Bioeng. Biotechnol.

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Succinic acid (SA), one of the 12 top platform chemicals produced from biomass, is a precursor of various high value-added derivatives. Specially, 1 mol CO2 is assimilated in 1 mol SA biosynthetic route under anaerobic conditions, which helps to achieve carbon reduction goals. In this review, methods for enhanced CO2 fixation in SA production and utilization of waste biomass for SA production are reviewed. Bioelectrochemical and bioreactor coupling systems constructed with off-gas reutilization to capture CO2 more efficiently were highlighted. In addition, the techno-economic analysis and carbon sequestration benefits for the synthesis of bio-based SA from CO2 and waste biomass are analyzed. Finally, a droplet microfluidics-based high-throughput screening technique applied to the future bioproduction of SA is proposed as a promising approach.

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Section: Enhanced Co 2 Fixation In Sa Biosynthesismentioning

confidence: 99%

Advances in succinic acid production: the enhancement of CO2 fixation for the carbon sequestration benefits

Lin,

Li,

Wang

et al. 2024

Front. Bioeng. Biotechnol.

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“…Increasing the ER size to cope with P450 protein folding and accumulation has yielded a concentration of 31.01 mg/L for parthenolide, a precursor for the anti-glioblastoma drug ACT001 76 . In another study, to maximize the peroxisome membrane storage capacity of S. cerevisiae, the number and size of peroxisomes have been increased through the expression of peroxisome biogenesisassociated peroxins 77 . The peroxisomal compartmentalization of acetyl-CoA, coupled with increased expression of sesquiterpenoid synthase and redirected precursor supply from the mitochondria to the cytosol, has increased production of terpene (+)-valencene 549fold (1.2 g/L) 74 .…”

Section: Rewiring Cellular Networkmentioning

confidence: 99%

A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast

Naseri

2023

Nat Commun

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Secondary natural products (NPs) are a rich source for drug discovery. However, the low abundance of NPs makes their extraction from nature inefficient, while chemical synthesis is challenging and unsustainable. Saccharomyces cerevisiae and Pichia pastoris are excellent manufacturing systems for the production of NPs. This Perspective discusses a comprehensive platform for sustainable production of NPs in the two yeasts through system-associated optimization at four levels: genetics, temporal controllers, productivity screening, and scalability. Additionally, it is pointed out critical metabolic building blocks in NP bioengineering can be identified through connecting multilevel data of the optimized system using deep learning.

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“…For example, autotrophic microbes possess their own cyclic CO 2 assimilation pathway, such as CBB cycle, reductive glycine pathway, reductive acetyl‐CoA pathway, 3‐hydroxypropionate (3‐HP) bicycle, 3‐HP/4‐hydroxybutyrate (4‐HB) cycle, dicarboxylate/4‐HB cycle, reductive tricarboxylic acid (TCA) cycle and reductive monocarboxylic acid cycle. In addition, most heterotrophic microbes possess non‐cyclic CO 2 assimilation pathways, such as anaplerotic pathways and the reductive branch of TCA cycle (Choi, Ahn, & Lee, 2022; Choi, Yu, & Lee, 2022). The CO 2 assimilation rates of such pathways are mainly determined by the rate of carboxylation reaction (Jensen, 2000; Pu & Han, 2022) since carboxylases have a relatively low catalytic efficiency compared to other enzymes (Bar‐Even et al, 2011).…”

Section: Can We Upgrade These Microbes?mentioning

confidence: 99%

“…Livestock farming consumes a lot of agricultural products including grains, and a vast amount of water and a large area of land are dedicated to produce animal feed. On the other hand, production of microbial biomass and single‐cell proteins has been reported to require much less land and water and emit less amount of CO 2 to produce an equivalent amount of nutrients (Choi, Ahn, & Lee, 2022; Choi, Yu, & Lee, 2022). Thus, the use of microbial biomass as animal feed can contribute to reducing GHG emission.…”

Section: How Do Such Microbial Processes Address Real‐world Problems?mentioning

confidence: 99%

Can microbes be harnessed to reduce atmospheric loads of greenhouse gases?

Ahn

Lee

Choi

et al. 2022

Environmental Microbiology

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Reducing atmospheric loads of greenhouse gases (GHGs), especially CO2 and CH4, has been considered the key to alleviating global crises we are facing, such as climate change, sea level elevation and ocean acidification. To this end, development of strategies and technologies for carbon capture, sequestration and utilization (CCSU) is urgently needed. Although physicochemical methods have been the most actively studied in the early stages of developing CCSU technologies, there have recently been growing interests in developing microbe‐based CCSU processes. In this article, we discuss advantages of microbe‐based CCSU technologies over physicochemical approaches and even plant‐based approaches. Next, various parts of the global carbon cycle where microorganisms can contribute, such as sequestering atmospheric GHGs, facilitating the carbon cycle, and slowing down the depletion of carbon reservoirs are described, emphasizing the impacts of microbes on the carbon cycle. Strategies to upgrade microbes and increase their performance in assimilating GHGs or converting GHGs to value‐added chemicals are also provided. Moreover, several examples of exploiting microbes to address environmental crises are discussed. Finally, we discuss things to overcome in microbe‐based CCSU technologies and provide future perspectives.

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Bacterial conversion of CO2 to organic compounds

Cited by 20 publications

References 69 publications

Advances in succinic acid production: the enhancement of CO2 fixation for the carbon sequestration benefits

Advances in succinic acid production: the enhancement of CO2 fixation for the carbon sequestration benefits

A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast

Can microbes be harnessed to reduce atmospheric loads of greenhouse gases?

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