Bacterial contamination of blood components

Septic Transfusion Reactions Involving Burkholderia cepacia Complex: A Review

“…As the growth temperature increased within the range of 25-40 degrees Celsius, there was a corresponding increase in the proportions of molecular species of PE Figure 3. A comprehensive comparison of transfusion-transmitted infection rates was conducted by analyzing hemovigilance reports from multiple countries [16][17][18]. Each point represents the value reported by each country.…”

“…analyzing hemovigilance reports from multiple countries [16][17][18]. Each point represents the value reported by each country.…”

“…These infections can be caused by bacteria, viruses, parasites, fungi, and prions [ 15 ]. The most common TTI is sepsis, which can result from the transfusion of blood components contaminated with bacteria [ 16 ]. Platelet components (PCs) are stored at room temperature (20–24 °C), providing an ideal environment for bacterial growth.…”

“…Previous aerobic culture surveillance studies have revealed that about 1 in 1000–3000 PCs were found to be bacterially contaminated [ 17 ]. However, the actual rates of septic transfusions were much lower, approximately 1 in 25,000 PCs (ranging from 1 in 13,000 to 100,000) [ 16 ]. The reported incidence of contamination varies widely based on location [ 18 ], collection type (e.g., apheresis vs. whole blood derived), and the level of implementation of mitigation measures.…”

“…Extensive research has been conducted on bacterial growth in blood products using in vitro studies [ 16 ]. The behavior of this growth is influenced not only by the type of bacteria [ 19 , 20 , 21 ] but also by factors such as the donor [ 22 , 23 ], the type of matrix (PCs or red blood cells) [ 19 , 20 , 21 ], and the temperature [ 24 ].…”