Bacterial colonization in patients with lower respiratory tract specimens: demographic profile and microbiological pattern

Abstract

found in 4.4% of hospital admissions and 6% of general practitioner consultations. [2] The increase in the antibiotic-resistant strains of bacteria, mainly in hospitals and in the community, poses a serious issue worldwide, thereby, causing difficulty in the control measures and necessitating abundant resources and expenditure for the same. [3] Pseudomonas aeruginosa is a gram-negative aerobic rod, which belongs to the family Pseudomonadaceae. It is an opportunistic pathogen and the predominant causative agent in nosocomial infections. It is also considered as the most challenging pathogen worldwide, because of its high rate of resistance to antimicrobial agent. [4] P. aeruginosa is an opportunistic pathogen with inherent resistance to many antibiotics and disinfectants, including antipseudomonal penicillins, ceftazidime, carbapenems, aminoglycosides, and ciprofloxacin. Globally, the multidrug-resistant bacterial strains prevalent in hospitals and community create Background: Pseudomonas aeruginosa is an opportunistic human pathogen and is the predominant causative agent in nosocomial infections. Resistance to nearly all the available antibiotics has been shown by P. aeruginosa, and multidrug-resistant P. aeruginosa (MDRPA) is the most important source of concern in hospital-acquired infections. Objective:To determine the prevalence of bacterial infection and the antibiotic sensitivity pattern of P. aeruginosa isolated from patients with lower respiratory tract infection. Materials and Methods:This study comprised 270 patients (151 treated as inpatients and 119 as outpatients). Sputum and bronchoalveolar lavage samples were subjected to gram staining, bacterial culture, and antibiotic sensitivity for bacterial isolates as per standard techniques.Result: The growth of pathogens was obtained from 55.9% of inpatients and 44% of outpatients. P. aeruginosa (25.2%) was the major organism isolated from hospitalized patients, whereas Moraxella catarrhalis (6.93%) was the most common pathogen isolated from outpatients. Imipenem was found to be the most effective antibiotic against P. aeruginosa.Conclusion: These findings focused on careful consideration for monitoring of antimicrobial use in order to reduce the occurrence and spread of antimicrobial-resistant pathogen.

A prospective cross-sectional study on assessment of antibiotic susceptibility pattern in patients with respiratory tract infections in Nilgiris district

“…The overall prevalence of isolated bacterial species was 38% S. aureus, 11% E. coli, 9% P. aeruginosa, and 4% K. pneumoniae. In LRTI, the highest pathogenic bacterium is S. aureus, which is dissimilar to the results obtained in studies conducted by Khan et al (2015), Saxena et al (2015), andSrivasthava et al (2013). The same bacterial species were isolated by Bajpai et al (2013) and Manikandan and Amsath (2013) in their study conducted on LRTI samples.…”

Bacteriological profile and antibiotic susceptibility patterns of lower respiratory tract infections in a tertiary care hospital, Central Kerala

“…1,3 It is responsible for 4.4% of all hospital admissions and 6% of general practitioner consultations. 4 It accounts for 3 to 5% of deaths in adults .Globally, about 4.2 million ALRI deaths are estimated to occur among all age groups. 1 The problem is much greater in developing countries where pneumonia is the most common cause of hospital attendance in adults.…”

Current Trend in the Antibiogram of Bacterial Pathogens of Adult Lower Respiratory Tract Infections in a Nigerian Tertiary Hospital

“…They are a significant contributor to out-patient consultation (6%) and all hospital admission (4.4%). Among adults up to 60 years, lower respiratory tract infections (LRTIs) account for 3%-5% of mortality [3]. Globally, it is estimated that about 4.2 million deaths from acute LRTIs occur among all age groups annually.…”