Bacterial cellulose-reinforced hydroxyapatite functionalized graphene oxide: a potential osteoinductive composite

Deepachitra, R.; Sastry, T. P.

doi:10.1007/s10570-014-0313-4

Cited by 61 publications

(38 citation statements)

References 47 publications

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“…Introduction of carboxyl groups to the C6 position by TEMPO oxidation revealed that surface functionalization plays an important role in the initial step of apatite nucleation (Nge et al, 2010). Impregnation of hydroxyapatite grown on a graphene oxide substrate onto a BC surface resulted in the formation of a novel material with osteoinductive potential, due to its improved biocompatibility towards human osteosarcoma MG-63 and fibroblast NIH-3T3 cell cultures (Ramani and Sastry, 2014). Introduction of aminoalkyl groups onto a BC surface through a silane chemical grafting approach led to the formation of a new material with no toxicity to human adiposederived mesenchymal stem cells (ADSCs).…”

Section: Surface Modificationsmentioning

confidence: 99%

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Sulaeva

Henniges

Rosenau

et al. 2015

Biotechnology Advances

363

275

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Section: Surface Modificationsmentioning

confidence: 99%

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Sulaeva

Henniges

Rosenau

et al. 2015

Biotechnology Advances

363

275

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“…The FESEM images (Figure 3c) and (Figure 3d) clearly show the exfoliated GO (Paulchamy et al 2015) and formation of thin wrinkled paper-like structure of GO (Ramani & Sastry, 2014) that occurs after the oxidation of graphene. GO has a different morphology compared with that of reduced GO (rGO), which has a smooth and a flat surface, probably due to the presence of functional groups consisting of oxygen ) and typically folded morphologies at its edge and surface (Cao & Zhang 2015).…”

Section: Absorption Of Fibronectin (Fn)mentioning

confidence: 99%

Adsorption of Extracellular Matrix Protein Fibronectin on the Surface of the Nanocomposite Particle of Graphene Oxide-Hydroxyapatite

Hashim¹,

Sawal²,

Rafie³

et al. 2018

JKUKM

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The study of biomaterials as implants have rapidly increased over recent decades to address the issues of tissue and bone disease. The combination of graphene oxide (GO) with hydroxyapatite (HA) is expected to promote the adsorption of protein fibronectin (FN). GO was produced by Hummer's method. Calcium hydroxide (Ca(OH) 2 at 0.1, 1.0 and 2.0 M) was used as a precursor of HA for the synthesis different GO compositions (0%, 0.1% and 1.0%) through wet chemical precipitation method. The molarity of Ca(OH) 2 and the composition of GO played an important role in the morphology, particle size, distribution of GO on HA surface and absorption of protein. GO and GO-HA composites were characterized using Fourier transform infrared spectroscopy, X-ray diffraction and field-emission scanning electron microscopy. Energy-dispersive X-ray spectroscopy was used to investigate protein adsorption. The average percentage yield of GO-HA composite production was highest (96.93%) at 2.0 M of Ca(OH) 2 . The optimum condition of GO-HA composite was 0.1 M Ca(OH) 2 and 0.1% GO composition, which resulted in needle-like shape with 48.38 nm width and 201.0 nm length, well conjugation, as well as the higher distribution of GO onto the HA surface. The elemental composition of carbon (C) of GO-HA was 44% and that of uncoated HA was 33%, which confirmed the adsorption of FN. Moreover, carbon element mapping proved that the absorption of FN towards GO-HA was successful. GO-HA nanocomposite can be a promising highly biocompatible material for medical implants. ABSTRAKKajian berkenaan biobahan sebagai implan telah berkembang dengan pesat sejak beberapa dekad kebelakangan ini bagi menangani isu-isu penyakit tisu dan tulang. Gabungan antara grafin oksida (GO) dan hidroksiapatit (HA) adalah dijangka dapat menggalakkan penjerapan protein fibronektin (FN). GO telah dihasilkan menerusi modifikasi daripada kaedah Hummer. Kemolaran kalsium hidroksida Ca(OH) 2 pada (0.1M, 1.0M dan 2.0M) digunakan sebagai larutan asas bagi HA untuk sintesis komposisi GO yang berbeza iaitu pada (0%, 0.1% dan 1.0%) melalui kaedah pemendakan kimia basah. Kemolaran Ca(OH) 2 dan komposisi GO adalah memainkan peranan penting dalam menentukan morfologi, saiz partikel, taburan GO terhadap permukaan HA dan penjerapan protein. GO dan komposit GO-HA dicirikan menggunakan Spektroskopi Inframerah Transformasi Fourier, Pembelauan Sinar-X, Mikroskop Electron Sekunder Bidang Emisi. Spektroskopi Serakan Tenaga Sinar-X pula digunakan untuk menganalisa penjerapan protein. Peratusan hasil tindak balas penghasilan komposit GO-HA adalah tertinggi (96.93%) pada molariti Ca(OH) 2 iaitu 2.0M. Kondisi optimum bagi komposit GO-HA adalah 0.1M Ca(OH) 2 dan 0.1% komposisi GO, yang mana menghasilkan GO-HA yang berbentuk seperti jarum dengan lebar 48.38 nm dan panjang saiz 201.0 nm, konjugasi yang baik dan bahkan menghasilkan taburan GO yang tinggi ke atas permukaan HA. Penjerapan FN dibuktikan oleh komposisi elemen karbon (C) bagi GO-HA iaitu 44% dan HA tanpa kehadiran GO adalah 33%. Tambahan pula, ...

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“…Nonetheless, cellulolytic enzymes can be used to degrade the material and this is often employed as are a number of other chemical processing strategies for native BC. One such group has shown that incorporating graphene oxide/hydroxyapatite with BC could help to create an osteoconductive scaffolds that have claimed to improve the biodegradability [54]. A second group used sodium periodate and hyaluronic acid along with BC to synthesize a scaffolding material with improved degradability for bone tissue engineering applications [55].…”

Section: Biodegradabilitymentioning

confidence: 99%

“…By also incorporating within the scaffolds enriched antimicrobial agents like gentamicin the functionalized scaffolds proved bactericidal activity while allowing human fibroblast growth. Osteoinductive BC-based materials have also been developed using a multi-component composite [54]. By utilizing graphene oxide, hydroxyapatite, and BC matrix, a compact scaffold network had been developed showing biocompatibility and osteoinductive potential as well as promoting cell adhesion and cell growth.…”

Section: Ex Situ Modification Techniquesmentioning

confidence: 99%

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Sandhu¹,

Arpa²,

Chen³

et al. 2019

rpm

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Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineering are pushing the value of this biomaterial to new levels. This review provides and in-depth discussion of these most recent approaches in processing as well as physical, chemical, and genetic modification of bacterial cellulose toward further improvement and expansion of its functionality. In addition, we provide specific attention to the marketed applications of the resulting engineered materials for medical research and conclude with prospective areas of consideration for expanding the clinical utility of this biomaterial to new directions.

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Bacterial cellulose-reinforced hydroxyapatite functionalized graphene oxide: a potential osteoinductive composite

Cited by 61 publications

References 47 publications

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Bacterial cellulose as a material for wound treatment: Properties and modifications. A review

Adsorption of Extracellular Matrix Protein Fibronectin on the Surface of the Nanocomposite Particle of Graphene Oxide-Hydroxyapatite

Engineering Bacterial Cellulose for Diverse Biomedical Applications

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