Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: In vitro diffusion studies

Trovatti, Eliane; Freire, Carmen S.R.; Pinto, Pedro Contreiras; Almeida, Isabel F.; Costa, Paulo; Silvestre, Armando J. D.; Neto, Carlos Pascoal; Rosado, Catarina

doi:10.1016/j.ijpharm.2012.01.002

Cited by 170 publications

(107 citation statements)

References 21 publications

(18 reference statements)

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“…BC and BC-Gly membranes were considered in this study, since glycerin is normally used as a plasticizer, to increase malleability, as well as the swelling (by promoting water holding and retention) of topical delivery systems [7,8]. Fig.…”

Section: Membrane Characterizationmentioning

confidence: 99%

“…Moreover, the peculiar nanofibrillar structure of BC should represent a suitable macromolecular support for inclusion of drugs and therefore for the development of specific controlled release systems. Previous studies documented the ability of BC membranes to modulate the release and bioavailability of model drugs for percutaneous administration [7,8], and hence, they were proposed as supports for topical or transdermal drug delivery. Therapeutic feasibility is dependent on the skin compatibility of these supports; however, little information is available concerning the skin compatibility and irritation potential of BC-based biomaterials.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Almeida

Pereira

Silva

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

173

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a b s t r a c tBacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24 h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p = 0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis.

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Section: Membrane Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Almeida

Pereira

Silva

et al. 2014

European Journal of Pharmaceutics and Biopharmaceutics

173

View full text Add to dashboard Cite

show abstract

“…The unique structural and physical properties, including excellent mechanical strength, ultrafine fibers, biodegradability, and high crystallinity, have received a considerable amount of research interest throughout the past decade (2e4). BC has been applied in the food industry (5,6), high-strength paper and electronic paper production (7e9), enzyme immobilization (10), biosensing (11), and in medical applications (3,12,13), such as wound dressings (14), artificial skin (15), artificial blood vessels (16), and drug delivery (17).…”

mentioning

confidence: 99%

Production of bacterial cellulose membranes in a modified airlift bioreactor by Gluconacetobacter xylinus

2015

Journal of Bioscience and Bioengineering

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“…The incorporation of organic/inorganic compounds in its structure is possible due to the network of ribbon-shaped nanosized cellulose fibrils and water presence. A number of studies in the literature report the successful use of BC membranes in biomedical applications due to their unique physical and mechanical properties [11][12][13]. Such membranes are particularly advantageous in the topical drug delivery systems that have the ability to absorb exudates and adhere to irregular skin surfaces, such as the oral mucosa.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Infrared to Visible Up-conversion in Biocellulose–yttrium Vanadate Nanoparticle Composite Membranes. Demonstration of Chloroaluminum Phthalocyanine Light Emission Under Up-converted Light Excitation

Nigoghossian¹,

Peres²,

Primo³

et al. 2014

Colloids and Interface Science Communications

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Biocellulose Chloroaluminum phthalocyanine Yttrium vanadate nanoparticles lanthanide ions photodynamic therapy photosensitizers drug delivery systems biomaterials composite membranes YVO 4 :(Yb 3+ -Er 3+ /Ho 3+ ) nanoparticles were incorporated in biocellulose membranes obtained from Gluconacetobacter xylinus. Materials present the property of converting near-infrared (NIR) into higher-energy visible light. Nanoparticles were prepared by optimizing towards higher emission intensity at the absorption wavelength range of chloroaluminum phthalocyanine (ClAlPc) used as a photosensitizer in the photodynamic therapy. The NIR excitation wavelength is advantageous for biological applications, as it allows deeper penetration into tissues than the UV-visible radiation commonly used for luminescence excitation. Up-conversion emission spectra obtained under excitation at 980 nm showed a preferential green emission for the Yb 3+ -Er 3+ system and a red emission for the Yb 3+ -Ho 3+ one. In the last case, by using mixtures of nanoparticles and ClAlPc the red emission (680 nm) of the phtalocyanine was observed through excitation by the up-converted emission of the nanoparticles (650 nm) which were excited in NIR (980 nm).

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Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: In vitro diffusion studies

Cited by 170 publications

References 21 publications

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

Production of bacterial cellulose membranes in a modified airlift bioreactor by Gluconacetobacter xylinus

Infrared to Visible Up-conversion in Biocellulose–yttrium Vanadate Nanoparticle Composite Membranes. Demonstration of Chloroaluminum Phthalocyanine Light Emission Under Up-converted Light Excitation

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