Bacterial cellulose membrane used as biological dressings on third-degree burns in rats

Brassolatti, Patrícia; Kido, Hueliton Wilian; Bossini, Paulo Sérgio; Gabbai-Armelin, Paulo Roberto; Otterço, Albaiza Nicoletti; Almeida‐Lopes, Luciana; Zanardi, Lisinéia Maria; Napolitano, Marcos Aurélio; Avó, Lucimar Retto da Silva de; Forato, L. A.; Araújo‐Moreira, F. M.; Parizotto, Nivaldo Antônio

doi:10.3233/bme-171710

Cited by 31 publications

(19 citation statements)

References 33 publications

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“…Our study evaluated the fourth day after the wounding and observed COX-2 expression in all groups, corresponding to its physiological response to the inflammatory process [35][36][37][38][39]. The CG group showed the higher immunolabeling, suggesting that the proposed treatments, isolated or in association, had positive effects in this immunoexpression and improved the resolution of the inflammatory phase.…”

Section: Discussionmentioning

confidence: 75%

Effect of photobiomodulation (670 nm) associated with vitamin A on the inflammatory phase of wound healing

et al. 2018

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Wound healing is a complex biological process with specific phases. Photobiomodulation (PBM) decreases the inflammatory infiltrate, stimulating fibroblast proliferation and angiogenesis, and therefore, is indicated for wound healing. Vitamin A is used to reverse the inhibitory effects on wound healing and accelerate the healthy granulation tissue. The study aimed to evaluate the effect of topical vitamin A and PBM (GaAlAs) in inflammatory phase of cutaneous wounds. Forty Wistar male rats were separated into four groups: (1) control (CG); (2) laser group (LG) GaAlAs, 670 nm, 30 mW, energy per point of 0.9 J, radiating by 1 point in 30 s; (3) vitamin A group (VitAG); and (4) laser group plus vitamin A (LG + VitAG). Wounds were surgically made by a punch biopsy with 10 mm of diameter on the back of the animals and all treatments were started according to the experiment. The treatments were administered for four consecutive days and biopsy was performed on day 4. We performed both H&E and immunohistochemistry analysis. The results were compared between groups by one-way analysis of variance ANOVA test with post hoc Tukey (p < 0.05). Inflammatory infiltrate increased significantly in LG compared to CG and VitAG (p < 0.05). Regarding angiogenesis, VEGF expression was increased significantly in LG and LG + VitAG groups, p < 0.01. The results indicate that proposed treatments were effective on the healing process improved by LG and LG + VitAG. We show that laser plus vitamin A enhances healing by reducing the wound area and may have potential application for clinical management of cutaneous wounds.

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Section: Discussionmentioning

confidence: 75%

Effect of photobiomodulation (670 nm) associated with vitamin A on the inflammatory phase of wound healing

et al. 2018

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“…Their results indicated that the use of bacterial cellulose dressings with and without lidocaine had comparable advanced repair outcomes, with both being more effective than the untreated control group. Skin appendages, mild inflammatory cell influx, collagen fiber organization and mild immunostaining were observed [26].…”

Section: Cellulosementioning

confidence: 99%

Smart Wound Dressings for Diabetic Chronic Wounds

Gianino

Miller

Gilmore

2018

Preprint

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Given their severity and non-healing nature, diabetic chronic wounds are a significant concern to the 30.3 million Americans diagnosed with diabetes mellitus (2015). Peripheral arterial diseases, neuropathy, and infection contribute to the development of these wounds, which lead to an increased incidence of lower extremity amputations. Early recognition, debridement, offloading, and controlling infection are imperative for timely treatment. However, wound characterization and treatment are highly subjective and based largely on the experience of the treating clinician. Many wound dressings have been designed to address particular clinical presentations, but a prescriptive method is lacking for identifying the particular state of chronic, non-healing wounds. The authors suggest that recent developments in wound dressings and biosensing may allow for the quantitative, real-time representation of the wound environment, including exudate levels, pathogen concentrations, and tissue regeneration. Development of such sensing capability could enable more strategic, personalized care at the onset of ulceration and limit the infection leading to amputation. This review presents an overview of the pathophysiology of diabetic chronic wounds, a brief summary of biomaterial wound dressing treatment options, and biosensor development for biomarker sensing in the wound environment.

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“…Tactile sensor (simultaneous sensing of temperature and pressure) [126] Strain-sensing protonated aerogels from cellulose nanofibrils [127] Drug delivery Peroral Paracetamol [49] Ibuprofen (colonic release) [70] Methotrexate (colonic release) [128] Transdermal Analgesics, antiphlogistics, corticoids, antihypertensives [50,51] Diclophenac [129] Propranolol [130] Topical Local anesthetics [131] Antiseptics [132,133] Antibiotics (gentamycin, ceftriaxone) [33,43] Antibacterial peptides [134] Other antimicrobial, antiinflammatory and antitumor drugs [135,136] 183…”

Section: Lithium Batteriesmentioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

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Bacterial cellulose membrane used as biological dressings on third-degree burns in rats

Abstract: Thus, was concluded that the bacterial cellulose-based biomaterial both in its pure state and enriched with lidocaine optimizing the full-thickness burn wound healing in rats.

Cited by 31 publications

References 33 publications

Effect of photobiomodulation (670 nm) associated with vitamin A on the inflammatory phase of wound healing

Effect of photobiomodulation (670 nm) associated with vitamin A on the inflammatory phase of wound healing

Smart Wound Dressings for Diabetic Chronic Wounds

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

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