Bacterial cellulose membrane associated with red propolis as phytomodulator: Improved healing effects in experimental models of diabetes mellitus

Picolotto, Aline; Pergher, Dáfiner; Pacheco, Guilherme; Machado, Keilla Gomes; Barud, Hernane da Silva; Roesch‐Ely, Mariana; Gonzalez, Mário H.; Tasso, Leandro; Figueiredo, Jozi Godoy; Moura, Sidnei

doi:10.1016/j.biopha.2019.108640

Cited by 39 publications

(36 citation statements)

References 43 publications

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“…Similar data have been reported using a bacterial cellulose membrane with 1% adsorbed Brazilian red propolis [152]. In the study, STZ-treated rats showed better closure of the lesions after treatment with the bacterial membrane with absorbed propolis than either ethanol or butanol extract [152]. The butanol extract-containing membrane markedly suppressed edema, hyperemia, and exudation, while the ethanol extract-containing membrane showed reduced but significant effects [152].…”

Section: Diabetic Complicationssupporting

confidence: 67%

“…In a similar context, “honey spring” propolis decreased proinflammatory cytokines, such as IL-1β, IL-6, and TNF-α, and also attenuated a cutaneous proteolytic enzyme, MMP9 [150]. Similar data have been reported using a bacterial cellulose membrane with 1% adsorbed Brazilian red propolis [152]. In the study, STZ-treated rats showed better closure of the lesions after treatment with the bacterial membrane with absorbed propolis than either ethanol or butanol extract [152].…”

Section: Diabetic Complicationsmentioning

confidence: 52%

“…In the study, STZ-treated rats showed better closure of the lesions after treatment with the bacterial membrane with absorbed propolis than either ethanol or butanol extract [152]. The butanol extract-containing membrane markedly suppressed edema, hyperemia, and exudation, while the ethanol extract-containing membrane showed reduced but significant effects [152]. Furthermore, both extract-containing membranes also stimulated wound contraction accompanied with an enhanced induction of TGF-β [152].…”

Section: Diabetic Complicationsmentioning

confidence: 99%

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Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Kitamura

2019

Molecules

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Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and rats, have some advantages, as genetic and microbiological variables can be controlled. On the other hand, cellular models allow the investigation of detailed molecular events evoked by propolis and derivative compounds. Taking advantage of animal and cellular models, accumulating evidence suggests that propolis extracts have therapeutic effects on obesity by controlling adipogenesis, adipokine secretion, food intake, and energy expenditure. Studies in animal and cellular models have also indicated that propolis modulates oxidative stress, the accumulation of advanced glycation end products (AGEs), and adipose tissue inflammation, all of which contribute to insulin resistance or defects in insulin secretion. Consequently, propolis treatment may mitigate diabetic complications such as nephropathy, retinopathy, foot ulcers, and non-alcoholic fatty liver disease. This review describes the beneficial effects of propolis on metabolic disorders.

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Section: Diabetic Complicationssupporting

confidence: 67%

Section: Diabetic Complicationsmentioning

confidence: 52%

Section: Diabetic Complicationsmentioning

confidence: 99%

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Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Kitamura

2019

Molecules

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“…Clinical trials with diabetic patients demonstrated that propolis consumption improved antioxidant parameters [ 167 ], glycemic control [ 168 , 169 ], and the lipid profile and renal function [ 170 ]. Propolis is also an antimicrobial agent with wound healing properties [ 171 , 172 ], which has proven especially useful for diabetic patients [ 173 , 174 ], who tend to develop difficult to heal wounds.…”

Section: Comorbidities and Evidence Of How Propolis Can Help Reduce Tmentioning

confidence: 99%

Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Berretta

Silveira

Capcha

et al. 2020

Biomedicine & Pharmacotherapy

196

194

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“…Propolis is a product of honeybee hives, containing mainly beeswax and a resin obtained from various plant sources such as apical buds, young leaves and exudates (Salatino & Salatino 2018). Red propolis, with Dalbergia ecastaphyllum (Daugsch et al, 2008;Silva et al, 2008) and Symphonia globulifera (Ccana-Ccapatinta et al, 2020) as its main botanical sources, has recently stood out as a natural medicinal product due to its various biological properties such as anti-inflammatory (Batista et al 2018), antitumoral (Salatino & Salatino 2018) antioxidant, cytotoxic (de Oliveira Reis et al, 2019), antimicrobial (Miranda et al 2019) activities and healing capacity (Picolotto et al 2019). The biological activity of red propolis is mainly related to isoflavones, which act in synergy with the other compounds.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antiproliferative activity of red propolis hydroalcoholic extract and its fractions obtained by partition

et al. 2020

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Abstract. Squarisi IS, De Freitas KS, Lemes DC, Ccana-Ccapatinta GV, Mejia JAA, Bastos JK, Veneziani RCS, Ambrosio SR, Tavares DC. 2018. Evaluation of the antiproliferative activity of red propolis hydroalcoholic extract and its fractions obtained by partition. Biofarmasi J Nat Prod Biochem 18: 66-69. The present study aimed to evaluate the cytotoxicity of red propolis hydroalcoholic extract (RPHE) and its fractions obtained by partition, hexanes (HF), dichloromethane (DF), ethyl acetate (AF) and n-butanol (BF), on tumor and non-tumor cell lines. For this purpose, the XTT colorimetric assay was performed on human lung fibroblasts (GM07492A, non-tumor cell), breast adenocarcinoma (MCF-7), glioblastoma (U343) and cervix adenocarcinoma (HeLa) cells. The results showed that RPHE, HF and DF presented not only cytotoxic potential to all tumor cell lines but also to normal cell line, indicating selectivity absence. HF presented the lowest IC50 (half minimal inhibitory concentration; 33.8-133.3 µg/mL), with significant difference from those observed for RPHE (137.0-262.7 µg/mL). BF and AF revealed an IC50 which was higher than 1250 µg/mL in all cell lines. The results showed that red propolis has substances with antiproliferative activity, indicating that its hexanes fraction may have substances with antitumor potential.

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Bacterial cellulose membrane associated with red propolis as phytomodulator: Improved healing effects in experimental models of diabetes mellitus

Cited by 39 publications

References 43 publications

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models

Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease

Evaluation of the antiproliferative activity of red propolis hydroalcoholic extract and its fractions obtained by partition

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