Bacterial cellulose in biomedical applications: A review

Picheth, Guilherme Fadel; Pirich, Cleverton Luiz; Sierakowski, Maria Rita; Woehl, Marco Aurélio; Sakakibara, Caroline Novak; Souza, Camilla Mariane Menezes; Martin, Andressa Amado; Silva, Renata da; Freitas, Rilton Alves de

doi:10.1016/j.ijbiomac.2017.05.171

Cited by 464 publications

(272 citation statements)

References 94 publications

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“…Cellulose and its derivatives, such as cellulose acetate have been used for 3D cellular engineering . Recently, they have been used for the synthesis of cellulose nanoparticles, hydrogels, aerogels, and films for a wide range of biomedical applications, summarized in Figure a . There are several approaches for designing cellulose‐based hydrogels, including the partial modification of hydroxyl groups by charged groups, promoting physical crosslinking .…”

Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

261

184

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Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, cost‐effectiveness, abundance, and accessible functional groups that allow facile chemical modifications with other biomaterials or biomolecules. Despite the advantages of gelatin, poor mechanical properties, sensitivity to enzymatic degradation, high viscosity, and reduced solubility in concentrated aqueous media have limited its applications and encouraged the development of gelatin‐based composite hydrogels. The drawbacks of gelatin may be surmounted by synergistically combining it with a wide range of polysaccharides. The addition of polysaccharides to gelatin is advantageous in mimicking the ECM, which largely contains proteoglycans or glycoproteins. Moreover, gelatin–polysaccharide biomaterials benefit from mechanical resilience, high stability, low thermal expansion, improved hydrophilicity, biocompatibility, antimicrobial and anti‐inflammatory properties, and wound healing potential. Here, we discuss how combining gelatin and polysaccharides provides a promising approach for developing superior therapeutic biomaterials. We review gelatin–polysaccharides scaffolds and their applications in cell culture and tissue engineering, providing an outlook for the future of this family of biomaterials as advanced natural therapeutics.

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Section: Gelatin–polysaccharides Composites In Cell Culture and Tissumentioning

confidence: 99%

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Afewerki

Sheikhi

Kannan

et al. 2018

Bioengineering & Transla Med

261

184

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“…There was however significant difference in BC yield from basal medium supplemented with the nitrogen sources, F (3, 4) =772, p<0.05. Liyaskira et al, 2017;Moniri et al, 2017;Picheth et al, 2017).…”

Section: Issn: 2319-7706 Volume 7 Number 08 (2018)mentioning

confidence: 99%

Bacterial Cellulose Production from Mature Black Spear Grass Hydrolysate by Gluconacetobacter xylinus: Effect of pH, Fermentation Time and Nitrogen Supplementation

Dirisu¹,

Braide²

2018

Int.J.Curr.Microbiol.App.Sci

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“…It also functions as a complex ingredient that reduces the side effects of other difficult materials . Additionally, BNC shows features that allow the use of BNC as a wound treatment material and to prepare artificial skin . Skin wound healing is a very complex and long‐lasting process.…”

Section: Introductionmentioning

confidence: 99%

Bacterial nanocelullose in biomedical applications: a review

Sionkowska

Mężykowska

Piątek

2019

Polymer International

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This review reports recent advances in the application of bacterial nanocellulose (BNC) in biomedical fields. BNC has attracted both academic and industrial attention as it shows interesting properties for both biomedical and cosmetic applications. Herein, the structure, properties and selected applications of BNC in the preparation of wound dressings and artificial skin are discussed in general, and detailed examples are also drawn from the scientific literature. In this review the most common applications are presented in detail together with issues related to regenerative medicine and biomedicine, skin tissue engineering, auricular cartilage reconstruction, bone regeneration and the treatment of traumatic tympanic membrane perforation. © 2019 Society of Chemical Industry

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Bacterial cellulose in biomedical applications: A review

Cited by 464 publications

References 94 publications

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Gelatin‐polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics

Bacterial Cellulose Production from Mature Black Spear Grass Hydrolysate by Gluconacetobacter xylinus: Effect of pH, Fermentation Time and Nitrogen Supplementation

Bacterial nanocelullose in biomedical applications: a review

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