Bacterial cellulose-based scaffold materials for bone tissue engineering

Torgbo, Selorm; Sukyai, Prakit

doi:10.1016/j.apmt.2018.01.004

Cited by 223 publications

(115 citation statements)

References 223 publications

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“…Clinical conditions, such as tumors, trauma, and diseases (osteitis and osteomyelitis) have highlighted the importance of bone regeneration. Tissue engineering has been a highly studied alternative to conventional therapeutics, such as autografts, xenografts, and allografts . As a result of its physicochemical properties, several BC composites and strategies using this type of material have been studied.…”

Section: Applicationsmentioning

confidence: 99%

“…HA exhibits a chemical and crystallographic structure analogous to the one of the bone and has been exhaustively studied for bone regeneration purposes. Moreover, HA has been known by its bioabsorbability, biocompatibility, bone‐bonding ability, good osteoconductivity, and bone mimicking crystalline structure . Examples of the research done in the last years encompassing BC and HA are listed in Table .…”

Section: Applicationsmentioning

confidence: 99%

“…BC production is mainly performed in nutrient‐rich culture media, either static or agitated. These two methods for BC production originate structures with distinct morphologies, thus, the choice of the method used will depend on the final application envisaged . In the production of BC under static culture, a pellicle is originated, while in an agitated culture, suspended fibers, irregular pellets, or even spheres are produced .…”

Section: Introductionmentioning

confidence: 99%

“…These two methods for BC production originate structures with distinct morphologies, thus, the choice of the method used will depend on the final application envisaged . In the production of BC under static culture, a pellicle is originated, while in an agitated culture, suspended fibers, irregular pellets, or even spheres are produced . Although agitated culture is faster relatively to static culture, the production yields are lower and there is a higher probability of mutations in the bacteria .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

View full text Add to dashboard Cite

show abstract

“…In the present proof-of-concept study, we demonstrate that apple-derived cellulose scaffolds can act as a suitable biomaterial for BTE. While other studies have shown promising results using bacterial cellulose for BTE [19], plant-derived cellulose has not been previously employed for this particular application. Importantly, hypanthium tissue possesses a microstructure with geometric characteristics similar to trabecular bone [7].…”

Section: Introductionmentioning

confidence: 99%

Plant-derived Cellulose Scaffolds for Bone Tissue Engineering

Latour

Tarar

Hickey

et al. 2020

Preprint

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Plant-derived cellulose biomaterials have recently been utilized in several tissue engineering applications. Naturally-derived cellulose scaffolds have been shown to be highly biocompatible in vivo, possess structural features of relevance to several tissues, as well as support mammalian cell invasion and proliferation. Recent work utilizing decellularized apple hypanthium tissue has shown that it possesses a pore size and properties similar to trabecular bone. In the present study, we examined the potential of apple-derived cellulose scaffolds for bone tissue engineering (BTE). Confocal microscopy revealed that the scaffolds had a suitable pore size for BTE applications. To analyze their in vitro mineralization potential, MC3T3-E1 pre-osteoblasts were seeded in either bare cellulose scaffolds or in composite scaffolds composed of cellulose and collagen I. Following chemically-induced differentiation, scaffolds were mechanically tested and evaluated for mineralization. The Young's modulus of both types of scaffolds significantly increased after cell differentiation. Alkaline phosphatase and Alizarin Red staining further highlighted the osteogenic potential of the scaffolds. Histological sectioning of the constructs revealed complete invasion by the cells and mineralization throughout the entire constructs. Finally, scanning electron microscopy demonstrated the presence of mineral aggregates deposited on the scaffolds after differentiation, and energy-dispersive spectroscopy confirmed the presence of phosphate and calcium. In summary, our results indicate that plant-derived cellulose is a promising scaffold candidate for bone tissue engineering applications.

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