Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

Hou, Shuaiwen; Xia, Zhaopeng; Pan, Jiajun; Wang, Ning; Gao, Hanchao; Ren, Jingli; Xia, Xuekui

doi:10.1002/mabi.202300333

Cited by 7 publications

(3 citation statements)

References 156 publications

(172 reference statements)

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“…Additionally, the pristine BC membrane also displayed a certain degree of wound healing promotion, this can be attributed to its capacity to create a favorable moist environment conducive to wound healing. [35,36] The in vivo antibacterial activity of the prepared membrane was assessed by performing local bacterial counts on the wound area 2 days after treatment. There was no significant difference in bacterial quan-tity between the BC group and the control group.…”

Section: In Vivo Wound Healing Evaluationmentioning

confidence: 99%

Enhancing Wound Healing and Bactericidal Efficacy: A Hydrogel Membrane of Bacterial Cellulose and Sanxan Gel for Accelerating the Healing of Infected Wounds

Zhao,

Shi,

Niu

et al. 2024

Adv Healthcare Materials

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Bacterial cellulose is an extracellular polysaccharide produced by microorganisms, offering advantages such as high water‐holding capacity, flexibility, and biocompatibility. However, its lack of bactericidal activity hampers its wide application. Usnic acid, a secondary metabolite derived from lichens of the Usnea genus, is recognized for its antibacterial and anti‐biofilm efficiency, coupled with anti‐inflammatory properties. Its water insolubility presents challenges for wide utilization and stable release. Sanxan gel, a novel polysaccharide, exhibits exceptional freeze‐thaw stability, suspension properties, and high elasticity, rendering it effective as a suspending agent to improve the bioavailability of water‐insoluble drugs. In this study, a hydrogel membrane was designed by combining bacterial cellulose and usnic acid suspended in sanxan gel through a simple in situ microorganism fermentation. The obtained membranes demonstrated excellent ability for sustained drug release, strong eradication capability against tested bacteria in both in vitro and in vivo experiments, effective inhibition of biofilm formation, and excellent hemocompatibility and cytocompatibility. Additionally, the composite membranes promoted wound healing with reduced inflammation and bacterial infection in a full‐thickness wound infection model in mice. This study provides innovative insights and strategies for the development of functional dressings for infected wounds in future clinical applications.This article is protected by copyright. All rights reserved

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Section: In Vivo Wound Healing Evaluationmentioning

confidence: 99%

Enhancing Wound Healing and Bactericidal Efficacy: A Hydrogel Membrane of Bacterial Cellulose and Sanxan Gel for Accelerating the Healing of Infected Wounds

Zhao,

Shi,

Niu

et al. 2024

Adv Healthcare Materials

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“…Various polymers have been investigated and utilized for wound-dressing applications, including both synthetic and natural options. Synthetic polymers, such as polyurethane [4] and polyethylene glycol [5], are commonly utilized, while natural polymers, like alginate [2,6], chitosan [7,8], collagen [9], hyaluronic acid [10,11], and bacterial cellulose (BC) [12,13], are also prominent choices. Natural polymers offer a range of appealing properties, including biocompatibility, biodegradability, and often, excellent moisture retention capabilities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care

Amorim,

Cavalcanti,

Medeiros

et al. 2024

Processes

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Bacterial cellulose (BC) can be chemically modified and combined with other materials to create composites with enhanced properties. In the medical field, biomaterials offer advantages, such as biocompatibility and sustainability, enabling improved therapeutic strategies and patient outcomes. Incorporating lidocaine into wound dressings offers significant potential benefits. In this study, transparent BC films were produced in situ with an undefined minimal culture medium with a yeast and bacteria co-culture system on black tea (Camellia sinensis) and white sugar medium for three days. Lidocaine was incorporated ex situ into the BC matrix, and the composite film was sterilized using gamma radiation. Drug-release studies showed a two-stage release profile, with an initial fast release (24.6%) followed by a slower secondary release (27.2% cumulative release). The results confirmed the incorporation of lidocaine into the BC, producing highly transparent films with excellent thermal stability, essential for the storage and transportation of wound dressings. This study highlighted BC properties and drug incorporation and release behavior. The findings contribute towards optimizing wound dressings with controlled drug release, showcasing the potential of transparent BC films as an effective platform for wound care and drug-delivery applications.

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“…Bacterial nanocellulose (BNC) is a biopolymer with extremely appealing properties and applications, especially in its native, never-dried state, such as biocompatibility, high hydrophilicity, flexibility, transparency, high mechanical strength and chemical stability, and high surface area [19,20,[26][27][28]. Never-dried BNC (NDBNC) has a net-like structure formed by nanofibrils of 40-60 nm in diameter and its purity is higher than that of plant cellulose.…”

Section: Introductionmentioning

confidence: 99%

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Moraru,

Dima,

Tritean

et al. 2023

Pharmaceuticals

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Biocompatible drug-delivery systems for soft tissue applications are of high interest for the medical and pharmaceutical fields. The subject of this research is the development of hydrogels loaded with bioactive compounds (inulin, thyme essential oil, hydro-glycero-alcoholic extract of Vitis vinifera, Opuntia ficus-indica powder, lactic acid, citric acid) in order to support the vaginal microbiota homeostasis. The nanofibrillar phyto-hydrogel systems developed using the biocompatible polymers chitosan (CS), never-dried bacterial nanocellulose (NDBNC), and Poloxamer 407 (PX) incorporated the water-soluble bioactive components in the NDBNC hydrophilic fraction and the hydrophobic components in the hydrophobic core of the PX fraction. Two NDBNC-PX hydrogels and one NDBNC-PX-CS hydrogel were structurally and physical-chemically characterized using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and rheology. The hydrogels were also evaluated in terms of thermo-responsive properties, mucoadhesion, biocompatibility, and prebiotic and antimicrobial effects. The mucin binding efficiency of hydrogel base systems was determined by the periodic acid/Schiff base (PAS) assay. Biocompatibility of hydrogel systems was determined by the MTT test using mouse fibroblasts. The prebiotic activity was determined using the probiotic strains Limosilactobacillus reuteri and Lactiplantibacillus plantarum subsp. plantarum. Antimicrobial activity was also assessed using relevant microbial strains, respectively, E. coli and C. albicans. TEM evidenced PX micelles of around 20 nm on NDBNC nanofibrils. The FTIR and XRD analyses revealed that the binary hydrogels are dominated by PX signals, and that the ternary hydrogel is dominated by CS, with additional particular fingerprints for the biocompounds and the hydrogel interaction with mucin. Rheology evidenced the gel transition temperatures of 18–22 °C for the binary hydrogels with thixotropic behavior and, respectively, no gel transition, with rheopectic behavior for the ternary hydrogel. The adhesion energies of the binary and ternary hydrogels were evaluated to be around 1.2 J/m2 and 9.1 J/m2, respectively. The hydrogels exhibited a high degree of biocompatibility, with the potential to support cell proliferation and also to promote the growth of lactobacilli. The hydrogel systems also presented significant antimicrobial and antibiofilm activity.

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Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

Cited by 7 publications

References 156 publications

Enhancing Wound Healing and Bactericidal Efficacy: A Hydrogel Membrane of Bacterial Cellulose and Sanxan Gel for Accelerating the Healing of Infected Wounds

Enhancing Wound Healing and Bactericidal Efficacy: A Hydrogel Membrane of Bacterial Cellulose and Sanxan Gel for Accelerating the Healing of Infected Wounds

Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

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