Bacterial Bronchitis and Bronchiectasis in Human Immunodeficiency Virus Infection

Verghese, Abraham; Al-Samman, Mounzer; Nabhan, Della; Naylor, Anthony D.; Rivera, Marisa

doi:10.1001/archinte.1994.00420180096011

Cited by 60 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other noninfective pulmonary conditions Although bronchiectasis appears to be more common in individuals who are HIV infected, there do not appear to be any studies investigating the role, if any, of cigarette smoking in its pathogenesis [156,157]. Likewise, the contribution of smoking to the well-recognised association between HIV infection and predisposition for development of pulmonary hypertension [158] is also uncertain, with the exception of a single study which assessed the association between HIV, human herpesvirus-8, sociodemographic information (such as smoking) and pulmonary hypertension [159].…”

Section: Obstructive Lung Disease (Copd and Asthma)mentioning

confidence: 99%

Impact of HIV infection and smoking on lung immunity and related disorders

2015

View full text Add to dashboard Cite

HIV-infected persons not only have higher rates of smoking than the general population, but are also unusually vulnerable to the associated adverse health effects, both infective and noninfective in origin. Indeed, in the setting of well-organised care and availability of highly active antiretroviral therapy, HIV-infected smokers lose more life-years to smoking than to HIV infection per se, presenting a major challenge to healthcare providers. Not surprisingly, the respiratory system is particularly susceptible to the damaging interactive chronic inflammatory and immunosuppressive effects of HIV and smoking, intensifying the risk of the development of opportunistic infections, as well as lung cancer and obstructive lung disorders. The impact of smoking on the immunopathogenesis and frequencies of these respiratory conditions in the setting of HIV infection, as well as on the efficacy of antiretroviral therapy, represent the primary focus of this review. @ERSpublications Smoking exacerbates the immunosuppressive/pro-inflammatory effects of HIV, increasing the risk of pulmonary disease

show abstract

Section: Obstructive Lung Disease (Copd and Asthma)mentioning

confidence: 99%

Impact of HIV infection and smoking on lung immunity and related disorders

2015

View full text Add to dashboard Cite

show abstract

“…In numerous recent studies the important morbidity associated with bronchitis, bronchiolitis and bronchiectasis have been highlighted [10,15,16,17,18]. Chest radiographs often reveal the impression of an interstitial infiltrate or multiple small nodules [19].…”

Section: Bacterial Pneumoniamentioning

confidence: 99%

Computed tomography of the thorax in HIV disease

Padley

King

1999

European Radiology

View full text Add to dashboard Cite

A wide variety of thoracic disorders can arise in patients infected with the human immunodeficiency virus (HIV), although recent developments in the therapeutic management of AIDS patients has resulted in a changing pattern of chest disease. The use of CT in the diagnosis and management of these thoracic manifestations is discussed along with the CT appearances of the various infectious and non-infectious complications of the acquired immune deficiency syndrome (AIDS) which are commonly encountered in clinical practice.

show abstract

“…The values in bold type in Table 2 4 appears to split into three subgroups, designated a, b and c (Fig. 3), with the ET12 isolates falling in cluster 4a.…”

Section: Euclidean Distancementioning

confidence: 99%

“…The organism is also a pathogen in individuals immunocompromised by chronic granulomatous disease (CGD) and AIDS [3,4]. B. cepacia shows considerable metabolic diversity, but is less prevalent in the environment than was once thought .…”

Section: Introductionmentioning

confidence: 99%

Subspecific differentiation of Burkholderia cepacia isolates in cystic fibrosis

Livesley

Baxter

Lambert

et al. 1998

Journal of Medical Microbiology

View full text Add to dashboard Cite

Thirty clinical isolates of Burkholderia cepacia from cystic fibrosis (CF) patients in the UK and Denmark were characterised, together with other clinical isolates and laboratory strains of B. cepacia, B. gladioli and B. vietnamiensis. Outer-membrane protein (OMP) profiles were determined, and the organisms were typed genotypically by pulsed-field gel electrophoresis after DNA restriction analyses with Xba I and Dra I. This latter method revealed four clusters among the clinical isolates studied; one of these contained isolates of the UK and intercontinental CF epidemic lineage ET12, a cluster which appeared to contain three subtypes. Each of the four clusters appeared less closely related to laboratory strains of B. cepacia than were laboratory strains of B. vietnamiensis, but more closely related to both these species than to B. gladioli. Two types of OMP profile were distinguished among the clinical isolates and strains, and were designated A and B. In type A isolates the major proteins had mol.wts of 39, 27 and 18 kDa. Type B strains additionally contained a group of proteins in the size range 80-90kDa, although detection of these depended upon the conditions for sample denaturation, In most cases, the OMP type correlated with the genotype, suggesting that examination of OMPs might be of value in the initial characterisation of isolates.

show abstract

Bacterial Bronchitis and Bronchiectasis in Human Immunodeficiency Virus Infection

Abstract: Recurrent bacterial bronchitis should be added to the list of bacterial infections that occur with increased frequency with HIV infection. Repeated bacterial bronchitis may lead to bronchiectasis, which may be more common in HIV infection than generally appreciated.

Cited by 60 publications

References 24 publications

Impact of HIV infection and smoking on lung immunity and related disorders

Impact of HIV infection and smoking on lung immunity and related disorders

Computed tomography of the thorax in HIV disease

Subspecific differentiation of Burkholderia cepacia isolates in cystic fibrosis

Contact Info

Product

Resources

About