Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance

Sabir, Nargis; Ikram, Aamer; Zaman, Gohar; Satti, Luqman; Gardezi, Adeel; Ahmed, Aziz; Ahmed, Parvez

doi:10.1016/j.ajic.2017.05.009

Cited by 122 publications

(111 citation statements)

References 18 publications

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“…Also, traveling to developing countries has been identified as a risk factor for acquiring drug-resistant bacteria [20]. Risk factors related to healthcare-associated infections (HAI) have been reported as well, including admission to the intensive care unit (ICU), use of catheter, and dialysis [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Matsui

Riley

2020

Antimicrob Resist Infect Control

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Background: Antimicrobial resistance is a serious public health problem. Fecal carriage of drug-resistant bacteria has been suggested as an important source of antimicrobial resistant genes (ARGs). We aimed to identify risk factors associated with fecal carriage of drug-resistant commensal Escherichia coli among healthy adult population. Methods: We conducted a systematic review and meta-analysis following the PRISMA guideline. We identified observational studies published from 2014 to 2019 through PubMed, Embase, and Web of Science. Studies were eligible if they investigated and reported risk factors and accompanying measure of associations for fecal carriage of drug-resistant E. coli for healthy population aged 18-65. Data on risk factors assessed in three or more studies were extracted. Results: Fifteen of 395 studies involving 11480 healthy individuals were included. The pooled prevalence of drug-resistant Enterobacteriaceae was 14% (95% confidence interval [CI] 8-23%). Antimicrobial use within the 12 months prior to stool culture (odds ratio [OR] 1.84 [95%CI 1.35-2.51]), diarrhea symptoms (OR 1.56 [95%CI 1.09-2.25]), travel to India (OR 4.15 [95%CI 2.54-6.78]), and vegetarian diet (OR 1.60 [95%CI 1.00(1.0043)-2.56(2.5587)]) were associated with increased risk of fecal carriage of drug-resistant E. coli. Among travellers, antimicrobial use (OR 2.81 [95%CI 1.47-5.36]), diarrhea symptoms (OR 1.65 [95%CI 1.02-2.68]), travel to India (OR 3.80 [95%CI 2.23-6.47]), and vegetarian diet (OR 1.92 [95%CI 1.13-3.26]) were associated with increased risk. Among general adult population, antimicrobial use (OR 1.51 [95%CI 1.17-1.94]), diarrhea symptoms (OR 1.53 [95%CI 1.27-1.84]), and travel to Southeast Asia (OR 1.67 [95%CI 1.02-2.73]) were associated with the increased risk of drug-resistant E. coli carriage. Conclusions:The findings indicate that dietary habit as well as past antimicrobial use and travel to high-risk country are associated with the risk of fecal carriage of drug-resistant commensal E. coli.

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Section: Introductionmentioning

confidence: 99%

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Matsui

Riley

2020

Antimicrob Resist Infect Control

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“…Culture-based methods have shown that CBs typically harbor more than a single microbial organism (5, 6, 21). Culture-independent metagenomic surveys have identified fastidious microbes including genera such as Actinomyces , Stenotrophomonas , Corynebacterium , and Finegoldia spp .…”

Section: Introductionmentioning

confidence: 99%

Nutritional Immunity and Antibiotic Drug Treatments Influence Microbial Composition but Fail to Eliminate Urethral Catheter Biofilms in Recurrently Catheterized Patients

Singh

Tsitrin

et al. 2019

Preprint

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21Polymicrobial biofilms that form on indwelling urethral catheters used by neurogenic 22 bladder patients are known to recur following catheter replacements. Uropathogens dominate in 23 catheter biofilms (CBs), grow and disperse as multi-cellular aggregates. Their microbial 24 complexity, the characteristics of host immune responses and the molecular crosstalk in this 25 ecosystem are incompletely understood. By surveying eight patients over up to six months with 26 meta-omics analysis methods, we shed new light on the longitudinal microbial dynamics in CBs 27 and the microbial-host crosstalk. There was evidence of chronic innate immune responses in all 28 patients. Pathogens dominated the microbial contents. Proteus mirabilis often out-competed other 29 species in cases of salt encrustation of catheters. The examination of proteomes in CBs and 30 associated urinary pellets revealed many abundant bacterial systems for transition metal ion (TMI) 31 acquisition. TMIs are sequestered by effector proteins released by activated neutrophils and 32 urothelial cells, such as lactotransferrin and calgranulins, which were abundant in the host 33 proteomes. We identified positive quantitative correlations among systems responsible for 34 siderophore biosynthesis, TMI/siderophore uptake and TMI cellular import in bacterial species, 35 suggesting competition for TMIs to support their metabolism and growth in CBs. Enterococcus 36 faecalis was prevalent as a cohabitant of CBs and expressed three lipoproteins with apparent TMI 37 acquisition functions. Fastidious anaerobic bacteria such as Veillonella, Actinobaculum, and 38 Bifidobacterium grew in CB communities that appeared to be oxygen starved. Finally, antibiotic 39 drug treatments were shown to influence microbial composition of CBs but failed to prevent re-40 colonization of urethral catheters with persisting and/or drug-resistant newly emerging pathogens. 41 42 43 44 45 46 Urethral catheter-associated urinary tract infection (CAUTI) is the most common type of 47 complicated UTI. CAUTIs have a higher risk of recurrence, pyelonephritis and bacteremia than 48 uncomplicated UTIs in nosocomial environments (1-3). Asymptomatic cases are usually 49 diagnosed as catheter-associated asymptomatic bacteriuria (CAASB). The use of nearly 100 50 million urethral catheters per year worldwide, the 3% to 10% incidence of bacteriuria over 24 51 hours following patient catheterization and an average bladder catheter insertion time of 72 h (2) 52 suggest an estimated 9 to 27 million CAUTI cases per year globally. Among the most common 53 causes are Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, 54 Enterococcus and Candida spp. (1, 3, 4). Indwelling Foley catheters are often used by patients 55 with anatomical urinary tract abnormalities and neurogenic bladder syndrome and retained in the 56 urinary tract for one week or longer. Microbial colonization is difficult to avoid even when catheters 57 are regularly replaced, and antibi...

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“…Bactérias multirresistentes pertencentes ao grupo ESKAPE são importantes patógenos de infecções relacionadas à assistência à saúde, sendo frequentemente identificados em infecções associadas a biofilmes e infecções crônicas, como a fibrose cística, endocardite, osteomielite, infecção urinária por cateter vesical, ou outros procedimentos invasivos associados ao uso de cateteres e sondas (LIN et al, 2018;REEN et al, 2018;DE ANGELIS et al, 2018;VELÁZQUEZ-ACOSTA et al, 2018;OTTON et al, 2017;ROSSI et al, 2017;JAIN et al, 2017;PARKER et al, 2017;SABIR et al, 2017;VUOTTO et al, 2017;VALIZADEH et al, 2017;BARDBARI et al, 2017;KRZYŚCIAK et al, 2017;HE et al, 2017;MAKOVCOVA, et al, 2017;KARLOWSKY et al, 2017). Embora, o fenótipo MR decorra da expressão de mecanismos mediados por genes intrínsecos e/ou adquiridos, o crescimento bacteriano na forma de biofilme contribui para um importante fenômeno fisiológico de resistência, o qual é inespecífico quanto ao substrato antimicrobiano (LIN et al, 2018;REEN et al, 2018;DE ANGELIS et al, 2018;VELÁZQUEZ-ACOSTA et al, 2018;MAUNDERS;WELCH, 2017).…”

Section: Discussionunclassified

“…Tendo em vista a complexidade e o custo do tratamento de infecções crônicas associadas à formação de biofilme, a busca de novas alternativas terapêuticas contra esse tipo de crescimento bacteriano tem sido considerada um desafio urgente para a medicina humana e veterinária (LIN et al, 2018;REEN et al, 2018;DE ANGELIS et al, 2018;VELÁZQUEZ-ACOSTA et al, 2018;BARDBARI et al, 2017;KRZYŚCIAK et al, 2017;HE et al, 2017;MAKOVCOVA, et al, 2017;OTTON et al, 2017;ROSSI et al, 2017;Jain et al, 2017;PARKER et al, 2017;SABIR et al, 2017;VUOTTO et;KRZYŚCIAK et al, 2017;KARLOWSKY et al, 2017;SWANSON et al, 2014;BAYNE, 2014).…”

Section: Discussionunclassified

“…A formação de biofilme tem sido observada em infecções causadas por bactérias Gram-negativas e Gram-positivas, acometendo preferencialmente superfícies abióticas, como dispositivos médicos e implantes, porém, também pode ser encontrado em tecidos bióticos, sendo associado com outras doenças e infeções como pneumonia em pacientes com fibrose cística, endocardite, osteomielite e feridas crônicas (Figura 3) (ROSSI et al, 2018;OTTO et al, 2017;JAIN et al, 2017;PARKER et al, 2017;SABIR et al, 2017;VUOTTO et al, 2017;VALIZADEH et al, 2017;BARDBARI et al, 2017;KRZYŚCIAK et al, 2017;HEet al, 2017;MAKOVCOVA, et al, 2017). Seu desenvolvimento ocorre de forma lenta, pode surgir em mais de um local e normalmente os sintomas associados demoram a serem apresentados.…”

Section: Biofilme Bacterianounclassified

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Avaliação da eficácia de agentes físicos e químicos contra biofilmes produzidos por clones de bactérias multirresistentes de importância clínica e epidemiológica no Brasil

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Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance

Cited by 122 publications

References 18 publications

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Nutritional Immunity and Antibiotic Drug Treatments Influence Microbial Composition but Fail to Eliminate Urethral Catheter Biofilms in Recurrently Catheterized Patients

Avaliação da eficácia de agentes físicos e químicos contra biofilmes produzidos por clones de bactérias multirresistentes de importância clínica e epidemiológica no Brasil

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Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance

Cited by 122 publications

References 18 publications

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Risk factors for fecal carriage of drug-resistant Escherichia coli: a systematic review and meta-analysis

Nutritional Immunity and Antibiotic Drug Treatments Influence Microbial Composition but Fail to Eliminate Urethral Catheter Biofilms in Recurrently Catheterized Patients

Avaliação da eficácia de agentes fí­sicos e químicos contra biofilmes produzidos por clones de bactérias multirresistentes de importância clínica e epidemiológica no Brasil

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Avaliação da eficácia de agentes físicos e químicos contra biofilmes produzidos por clones de bactérias multirresistentes de importância clínica e epidemiológica no Brasil