Bacterial and Protozoan Lipoxygenases Could be Involved in Cell-to-Cell Signaling and Immune Response Suppression

Features of microbiota in underweight premature infants

“…Изучение качественных и количественных параметров нами проводилось с использованием бактериологического метода, который в данном случае позволил не только выделить условнопатогенные микроорганизмы, но и определить их различные фенотипические свой ства, в частности, чувствительность к противомикробным препаратам, наличие факторов патогенности [28,29]. Кроме того, в лечебных учреждениях достаточно часто используют данный метод определения УПМ, по сравнению с молекулярно-генетическим подходом.…”

Bacterial lipoxygenases are associated with host-microbe interactions and may provide cross-kingdom host jumps

“…The method of updating the dataset is the same as for collecting the initial dataset (described in our previous paper [8]). The difference was that we used pathogen and symbiont LOX sequences form the “old” dataset as queries and downloaded all hits that belong to pathogens and symbionts (they were typically sorted at the top of the hit list) along with some cyanobacterial and myxobacterial LOXs (according to our previous research, they are outgroups for all pathogen and symbiont LOXs).…”

“…We started with the same dataset of bacterial lipoxygenases as used in our previous research [6]. However, we are updating it in an ongoing manner because LOX-like sequences are constantly added to protein databases, and some sequences are revised and deleted.…”

“…In our previous paper [8], we have noticed some additional traits common for lipoxygenase-positive bacteria. They were opportunistic pathogens (these bacteria are prone to affect immunocompromised people, especially patients with cystic fibrosis).…”

Bacterial lipoxygenases: Biochemical characteristics, molecular structure and potential applications

“…An in vitro study indicated that P. aeruginosa LOX also exhibits lipoxin synthase activity, leading to the production of lipoxin, an anti-inflammatory mediator, that silences the host immune response (Banthiya et al, 2016). In line with these speculations, it has been proposed on the basis of evolutionary and taxonomic analysis that bacterial LOXs are primarily associated with multicellularity and serve as versatile virulence/symbiosis factors which suppress the host immune response (Kurakin et al, 2020). Moreover, it has been speculated that bacterial LOXs are associated with a broad range of hosts, ranging from coral to plants and humans, which suggests that bacterial LOXs may play an important role in host-microbe interactions and provide cross-kingdom host jumps (Kurakin, 2022).…”