Bacterial and fungal bloodstream infections in solid organ transplant recipients: results from a Danish cohort with nationwide follow-up

Abstract

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Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

“…Similarly, the Spanish cohort study RESITRA reported highest incidence rates of bacteraemia in lung and pancreas transplant recipients 14 . In contrast, a Danish national cohort study reported higher incidence of bacteraemia in liver and kidney SOTr as compared to other SOT categories 15 …”

“…14 In contrast, a Danish national cohort study reported higher incidence of bacteraemia in liver and kidney SOTr as compared to other SOT categories. 15 Most BJI were rather late post-transplant complications, with the exception of thoracic organ transplant recipients, who developed an infection within the 1st year post-transplant, predominately nonvertebral osteomyelitis. In fact, when we looked at time to infection for thoracic (heart and lung) versus abdominal (liver, kidney, kidneypancreas) transplant recipients, BJI occurred significantly earlier in the former (median 5.5 months, IQR: 1-14 versus 22 months, IQR: 10.5-54.5; p = .0001).…”

“… 14 In contrast, a Danish national cohort study reported higher incidence of bacteraemia in liver and kidney SOTr as compared to other SOT categories. 15 …”

Ceftazidime/Avibactam for the Treatment of Carbapenem-Resistant Pseudomonas aeruginosa Infection in Lung Transplant Recipients

“…Considering the immunosuppressive drugs used for the prevention and therapy of rejection event, immune function was impaired and the risk of infection was increased in SOT recipients. 34 In a single-center cohort of kidney transplantation with carbapenem-resistant Klebsiella pneumoniae (CRKP) infection, recipients in the CAZ/AVI therapy group had better clinical outcomes than those in the other antibiotic regimens group, demonstrating the effectiveness of CAZ/AVI. 35 Moreover, another retrospective study evaluated the efficacy of CAZ/AVI in liver transplant recipients with CRKP infection, and showed the clinical benefit of CAZ/AVI with promising results.…”

“…Considering the immunosuppressive drugs used for the prevention and therapy of rejection event, immune function was impaired and the risk of infection was increased in SOT recipients. 34 In a single- 35 Moreover, another retrospective study evaluated the efficacy of CAZ/AVI in liver transplant recipients with CRKP infection, and showed the clinical benefit of CAZ/AVI with promising results. 29 Besides, patients who underwent lung transplantation with XDR-GNB infection were reviewed.…”