Bacterial Agents in Diabetic Foot Infections and Their Biofilm Formation Rates

Öztürk, Şerife Barçın; Ertuğrul, Mustafa Bülent; Çörekli, Esra

doi:10.5222/tmcd.2017.033

“…Yine bazı çalışmalarda, biyofilm Şekil 2. (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Son yıllarda yapılmış çalışmalarda bildirilen dirençli Pseudomonas infeksiyonu gelişme oranları da %18-21' e ulaşmıştır (19,25,28).…”

Section: Soru 2: Hangi Durumlarda Dirençli Patojenler Düşünülmelidir?unclassified

“…Diyabetik Ayak İnfeksiyonlarında Etken Mikroorganizmalar Nelerdir?Diyabetik ayak infeksiyonlarının etkenleri, infeksiyonun akut ya da kronik olmasına ve şiddetine bağlı olarak değişiklik gösterir. Türkiye' de çeşitli çalışmalarda belirlenen DAİ etkenleri Tablo 1' de gösterilmiştir(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Selüliti olan ve daha önce antibiyotik kullanmamış hastalarda gelişen yüzeysel DAİ'lerden, daha çok Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes gibi aerop Gram-pozitif koklar sorumludur.…”

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2024

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Surgical management of DF ulcers can be analyzed in five sections: (a) Urgent ulcer intervention; abscess drainage and/or debridement, (b) surgical interventions for vascular pathologies, (c) ulcer closure interventions; reconstruction methods; graft and flap surgery, (d) reconstruction of bone and foot pathologies for ulcer prevention and treatment (Charcot foot deformity, Achilles lengthening, tenotomy, and osteotomies, etc.), (e) minor and major amputations when necessary. 14) Amputation may be a more appropriate choice when infected tissue cannot be completely cleaned with debridement, when the patient is bedridden or has a non-functional extremity, when it is believed that adequate revascularization cannot be achieved by orthopedic and plastic surgical interventions, in cases where reconstruction is nearly impossible, and in dialysis patients. 15) The goal of post-DFI reconstruction is to allow the ankle to reach a neutral position and to make the plantar surface of the foot have a balanced contact with the ground. 16) Selected ulcer care products can be used based on the characteristics of the ulcer to support and accelerate ulcer healing, reduce the risk of complications, ensure patient comfort during treatment, and improve quality of life. 17) DF ulcers often develop due to improper shoe selection during the structural and biomechanical changes, resulting in fluid accumulation and callus formation around bone surfaces. 18) Orthoses, which distribute pressure over the widest possible area, are the most effective means of reducing plantar pressure in the foot. 19) Hyperbaric oxygen therapy is beneficial in addition to revascularization and antibiotic therapy, which are the primary treatments for pathologies causing tissue hypoxia, such as ischemia, infection, and edema. 20) Negative pressure ulcer therapy is an additional adjunct method to conventional techniques, and it can contribute to the healing process with the correct indications. 21) In cases where the infection is under control, active osteomyelitis is absent, topical epidermal growth factor (EGF) can be used for Meggitt-Wagner ulcer classification grade 1-3, and intralesional EGF applications can be used for grade 3-4 in addition to standard treatments. 22) Preventive medical practices in people with diabetes, collaborative efforts of the patients, their families, and the medical team, and regular patient education are necessary to prevent DF ulcer development. In the event of DF ulcer development, interdisciplinary collaboration in moderate/severe infections is essential for early treatment and infection prevention.

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“…Diyabetik ayak enfeksiyon etkenlerinin biyofilm oluşturmasını önlemek veya oluşan biyofilmi ortadan kaldırmak için yeni tedavi stratejilerinin geliştirilmesi gerektiği, biyofilm yönetiminin kronik yara tedavisinin en etkili basamağını oluşturduğu ve bu konuda az sayıda çalışma olduğu vurgulanmaktadır. 18…”

Section: P Aeruginosa Pao1 Pseudomonas Protegensunclassified

Biofilm Formation by Mixed Gram-Negative Bacteria Cultures and its Effects on Ciprofloxacin Sensitivity: Cross-Sectional Research

BİTAR,

YILMAZ

2024

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Diagnosis, Treatment, Prevention, and Rehabilitation of Diabetic Foot Ulcers and Infections: Turkish Consensus Report, 2024

Kadanali,

Saltoglu,

Ak

et al. 2024

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Surgical management of DF ulcers can be analyzed in five sections: (a) Urgent ulcer intervention; abscess drainage and/or debridement, (b) surgical interventions for vascular pathologies, (c) ulcer closure interventions; reconstruction methods; graft and flap surgery, (d) reconstruction of bone and foot pathologies for ulcer prevention and treatment (Charcot foot deformity, Achilles lengthening, tenotomy, and osteotomies, etc.), (e) minor and major amputations when necessary. 14) Amputation may be a more appropriate choice when infected tissue cannot be completely cleaned with debridement, when the patient is bedridden or has a non-functional extremity, when it is believed that adequate revascularization cannot be achieved by orthopedic and plastic surgical interventions, in cases where reconstruction is nearly impossible, and in dialysis patients. 15) The goal of post-DFI reconstruction is to allow the ankle to reach a neutral position and to make the plantar surface of the foot have a balanced contact with the ground. 16) Selected ulcer care products can be used based on the characteristics of the ulcer to support and accelerate ulcer healing, reduce the risk of complications, ensure patient comfort during treatment, and improve quality of life. 17) DF ulcers often develop due to improper shoe selection during the structural and biomechanical changes, resulting in fluid accumulation and callus formation around bone surfaces. 18) Orthoses, which distribute pressure over the widest possible area, are the most effective means of reducing plantar pressure in the foot. 19) Hyperbaric oxygen therapy is beneficial in addition to revascularization and antibiotic therapy, which are the primary treatments for pathologies causing tissue hypoxia, such as ischemia, infection, and edema. 20) Negative pressure ulcer therapy is an additional adjunct method to conventional techniques, and it can contribute to the healing process with the correct indications. 21) In cases where the infection is under control, active osteomyelitis is absent, topical epidermal growth factor (EGF) can be used for Meggitt-Wagner ulcer classification grade 1-3, and intralesional EGF applications can be used for grade 3-4 in addition to standard treatments. 22) Preventive medical practices in people with diabetes, collaborative efforts of the patients, their families, and the medical team, and regular patient education are necessary to prevent DF ulcer development. In the event of DF ulcer development, interdisciplinary collaboration in moderate/severe infections is essential for early treatment and infection prevention.

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Bacterial Agents in Diabetic Foot Infections and Their Biofilm Formation Rates

Abstract: ÖZ Amaç: Yara yatağı bakterilerin üremesi için ideal bir yüzeydir ve mikrobiyal enfeksiyonun yara iyileşmesi üze-

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References 30 publications

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Biofilm Formation by Mixed Gram-Negative Bacteria Cultures and its Effects on Ciprofloxacin Sensitivity: Cross-Sectional Research

Diagnosis, Treatment, Prevention, and Rehabilitation of Diabetic Foot Ulcers and Infections: Turkish Consensus Report, 2024

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