Bacterial aetiology of neonatal meningitis: A study from north-east India

A Comprehensive Review of Meningococcal Disease Burden in India

“…These 32 publications reported data on meningococcal disease from different regions of India: Delhi ( n = 11) [ 16 , 24 – 26 , 34 , 40 , 45 – 47 , 52 , 53 ], Karnataka ( n = 5) [ 36 , 43 , 44 , 49 , 50 ], Assam ( n = 3) [ 28 , 32 , 33 ], Kashmir ( n = 2) [ 27 , 41 ], Chandigarh ( n = 2) [ 37 , 51 ], Meghalaya ( n = 2) [ 30 , 31 ], multiple states ( n = 2) [ 38 , 39 ], Maharashtra ( n = 1) [ 29 ], Uttar Pradesh ( n = 1) [ 23 ], Odisha ( n = 1) [ 48 ], Tripura ( n = 1) [ 42 ] and Tamil Nadu ( n = 1) [ 35 ] (Table 2 ).…”

“…Excluding the 11 case reports, a total of 20 publications reported disease epidemiology from either retrospective or prospective studies [ 16 , 26 – 30 , 32 , 34 – 36 , 38 – 43 , 45 , 47 , 49 , 51 ]. The study design was not reported for one publication [ 50 ] (Table 2 ).…”

“…An equal number of publications reported data for the pediatric population ( n = 11) [ 23 , 25 , 29 , 35 , 38 , 46 , 48 – 52 ] and mixed populations of different age groups including neonatal, pediatric, adolescent and adult, respectively [ 16 , 28 , 30 , 34 , 36 , 39 , 40 , 42 , 43 , 45 , 47 ]. A few publications reported data specifically for adult ( n = 5) [ 26 , 27 , 41 , 44 , 53 ], adolescent ( n = 3) [ 24 , 31 , 37 ] and neonatal ( n = 2) [ 32 , 33 ] populations, respectively (Table 2 ).…”

“…Twelve publications presented data from non-outbreak settings in India, which reported cases mostly from regions that did not usually have outbreaks. Most publications reported percentages of confirmed cases in the range of 0.1 ( n = 2)–7.6% ( n = 18) [ 28 , 29 , 32 , 35 , 36 , 38 , 43 , 49 – 51 ] of suspected cases, and in one publication from Delhi, 71.4–100% ( n = 34) of the samples were positive for N.meningitidis , depending on the technique used for diagnosis [ 40 ]. Mortality was not reported in any of these publications (Table 2 ).…”

Extended-spectrum β-lactamase & carbapenemase-producing Gram-negative bacilli in neonates from a tertiary care centre in Dibrugarh, Assam, India

“…(n=6) and E. coli (n=1) were characterized. Three isolates of A. baumannii , two of Klebsiella and one isolate of Pseudomonas detected by the direct CSF polymerase chain reaction (PCR) 13 were included for genotypic characterization. Isolates resistant to at least one of the following: cefotaxime, ceftriaxone, ceftazidime, or cefepime were screened for ESBL as per the Clinical Laboratory Standard Institute (CLSI) guidelines 14 .…”