Bacteria-targeted photothermal therapy for combating drug-resistant bacterial infections

Abstract

Photothermal therapy is an ideal non-invasive treatment for bacterial infections. However, if the photothermal agents are unable to target bacteria, it can also cause thermal damage to healthy tissue. This...

PMMA/PDMS/MXene Nanofibers for Postsurgery Monitoring of Vascular Implants

“…There is no significant change in hemolysis for samples from 0 to 5 wt % MXene; however, there is a slight increase in hemolysis with samples from 10 wt % and above. When exposed to red blood cells, MXene nanosheets contain knife-like edges, which have a hemolytic effect, allowing hemoglobin to leak out . In this instance, both partial and full encapsulation of the nanosheets in the PMMA/PDMS matrix restricts the hemolysis rate to less than 5%, which is considered nonhemolytic.…”

“…When exposed to red blood cells, MXene nanosheets contain knife-like edges, which have a hemolytic effect, allowing hemoglobin to leak out. 34 In this instance, both partial and full encapsulation of the nanosheets in the PMMA/PDMS matrix restricts the hemolysis rate to less than 5%, which is considered nonhemolytic. Plasma protein adhesion onto the lumen surface of an artificial graft marks the initial stage in postimplantation healing, often triggering platelet adhesion, activation, and aggregation.…”

Nanogold-coated stent facilitated non-invasive photothermal ablation of stent thrombosis and restoration of blood flow

“…Photothermal therapy (PTT) is a well-established but burgeoning eld of medical research that has been widely employed in wound healing, [14][15][16][17] treatment of bacterial infection, [18][19][20][21] pain relief, 22,23 drug delivery [24][25][26][27] and for selective thermal ablation of malignant tissues [54][55][56][57][58] at temperatures above 40 °C, which ensues protein denaturation and disruption of target cell membranes. Subsequent studies from our group and others established the anti-thrombotic attributes of PTT as it leads to disintegration of brin-rich clots by segregation of component brin strands, which are then washed off from the lesion site under arterial hydrodynamic shear.…”

“…Advantages of minimal invasive photothermal therapy have widely been recognized as an effective, safer and sound approach in wound healing, [14][15][16][17] treatment of bacterial infection, [18][19][20][21] pain relief, 22,23 drug delivery [24][25][26][27] and cancer management. [27][28][29] For example, an attempt has been made to manage obstructive rectal cancer 30 or minimize rat esophageal granulation tissue 31 with heat generated from photothermally active stents.…”

Novel Antibacterial Materials and Coatings—A Perspective by the Editors

“…The delivery of AgNPs has been a huge research focus utilizing different kinds of platforms, including pH- and temperature-responsive hydrogels [ 18 ], mesoporous silica [ 19 ], microneedles [ 20 ], and 3D printings [ 21 ], all of which show exceptional potential to eliminate infection safely. Other attractive approaches include photothermal therapy of bacteria using near-infrared light (NIR), generating a cocktail of reactive oxygen species and spatial heat and providing a convenient method for ablating bacterial infection with an on-demand release strategy [ 22 , 23 ]. For example, Min and colleagues developed a dual-function pH-sensitive hydrogel capable of real-time wound monitoring with on-demand photothermal therapy that resulted in 99% bacterial inhibition, offering a highly innovative platform for smart infection management [ 24 ].…”