Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Xiao, Susu; Shi, Huan; Zhang, Yan; Fan, Yu; Wang, Li; Li, Xiang; Liu, Yanlin; Zhao, Ling; Shao, Fu

doi:10.1186/s12951-022-01373-1

Cited by 37 publications

(37 citation statements)

References 55 publications

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“… 40–42 Intravenously administered Bif or its hybrid did not result in any significant toxicity in the heart, liver, spleen, lung, kidney and blood of mice. 27 , 28 Bif-mediated delivery of doxorubicin NPs to the hypoxic area of breast tumors improved the therapeutic outcome. 27 Therefore, Bif-based biohybrids are a safe and efficient drug delivery system for cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

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Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

Shi¹,

Chen²,

Liu³

et al. 2023

IJN

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Background Chemotherapy still plays a dominant role in cancer treatment. However, the inability of conventional chemotherapeutic drugs to reach the hypoxic zone of solid tumors significantly weakens their efficacy. Bacteria-mediated drug delivery systems can be an effective targeting strategy for improving the therapeutic outcomes in cancer. Anaerobic bacteria have the unique ability to selectively transport drug loads to the hypoxic regions of tumors. Methods We designed a Bifidobacterium infantis (Bif)-based biohybrid (Bif@PDA-PTX-NPs) to deliver polydopamine (PDA)-coated paclitaxel nanoparticles (PTX-NPs) to tumor tissues. Results The self-driven Bif@PDA-PTX-NPs maintained the toxicity of PTX as well as the hypoxic homing tendency of Bif. Furthermore, Bif@PDA-PTX-NPs significantly inhibited the growth of A549 xenografts in nude mice, and prolonged the survival of the tumor-bearing mice compared to the other PTX formulations without any systemic or localized toxicity. Conclusion The Bif@PDA-PTX-NPs biohybrids provide a new therapeutic strategy for targeted chemotherapy to solid tumors.

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Section: Discussionmentioning

confidence: 99%

“… 25 , 26 Bif can be combined with nano-drugs in vitro or through antigen-antibody binding in vivo to form biohybrids for targeted drug delivery to hypoxic tumor zones. 27 , 28 …”

Section: Introductionmentioning

confidence: 99%

Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

Shi¹,

Chen²,

Liu³

et al. 2023

IJN

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“…The result showed that DOX-PFP-PLGA were successfully connected to the surface of EcM. According to the reported method (Xiao et al, 2022), we next validated the effect of DOX-PFP-PLGA coating on bacterial activity. By counting the bacterial colonization in each plate, it was found that no statistical difference in the activity of bacteria attaches or non-attach nanodroplets (Figure 3D).…”

Section: Characterization Of Sonobacteriabotmentioning

confidence: 92%

Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release

Wang²,

Feng³

et al. 2023

Front. Bioeng. Biotechnol.

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Bacteria-driven biohybrid microbots have shown great potential in cancer treatment. However, how precisely controlling drug release at the tumor site is still an issue. To overcome the limitation of this system, we proposed the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM). Doxorubicin (DOX) and perfluoro-n-pentane (PFP) were encapsulated in polylactic acid-glycolic acid (PLGA) to form ultrasound-responsive DOX-PFP-PLGA nanodroplets. Then, DOX-PFP-PLGA@EcM is created by DOX-PFP-PLGA amide-bonded to the surface of E. coli MG1655 (EcM). The DOX-PFP-PLGA@EcM was proved to have the characteristics of high tumor-targeting efficiency, controlled drug release capability, and ultrasound imaging. Based on the acoustic phase change function of nanodroplets, DOX-PFP-PLGA@EcM enhance the signal of US imaging after ultrasound irradiation. Meanwhile, the DOX loaded into DOX-PFP-PLGA@EcM can be released. After being intravenously injected, DOX-PFP-PLGA@EcM can efficiently accumulate in tumors without causing harm to critical organs. In conclusion, the SonoBacteriaBot has significant benefits in real-time monitoring and controlled drug release, which has significant potential applications for therapeutic drug delivery in clinical settings.

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“…These results indicated that B. bifidum and PFH@CL/Fe 3 O 4 NPs successfully synthesized biological target magnetic NPs, which confirmed that the B. bifidum binds to cationic liposome NPs through electrostatic adsorption. 26,27,37…”

Section: Synthesis and Characterization Of Pfh@cl/fe 3 O 4 Nps And B ...mentioning

confidence: 99%

US/MR Bimodal Imaging-Guided Bio-Targeting Synergistic Agent for Tumor Therapy

Jiang¹,

Wang²,

Tang³

et al. 2022

IJN

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Breast cancer is detrimental to the health of women due to the difficulty of early diagnosis and unsatisfactory therapeutic efficacy of available breast cancer therapies. High intensity focused ultrasound (HIFU) ablation is a new method for the treatment of breast tumors, but there is a problem of low ablation efficiency. Therefore, the improvement of HIFU efficiency to combat breast cancer is immediately needed. This study aimed to describe a novel anaerobic bacteria-mediated nanoplatform, comprising synergistic HIFU therapy for breast cancer under guidance of ultrasound (US) and magnetic resonance (MR) bimodal imaging. Methods: The PFH@CL/Fe 3 O 4 nanoparticles (NPs) (Perfluorohexane (PFH) and superparamagnetic iron oxides (SPIO, Fe 3 O 4 ) with cationic lipid (CL) NPs) were synthesized using the thin membrane hydration method. The novel nanoplatform Bifidobacterium bifidum-mediated PFH@CL/Fe 3 O 4 NPs were constructed by electrostatic adsorption. Thereafter, US and MR bimodal imaging ability of B. bifidum-mediated PFH@CL/Fe 3 O 4 NPs was evaluated in vitro and in vivo. Finally, the efficacy of HIFU ablation based on B. bifidum-PFH@CL/Fe 3 O 4 NPs was studied. Results: B. bifidum combined with PFH@CL/Fe 3 O 4 NPs by electrostatic adsorption and enhanced the tumor targeting ability of PFH@CL/Fe 3 O 4 NPs. US and MR bimodal imaging clearly displayed the distribution of the bio-targeting nanoplatform in vivo. It was conducive for accurate and effective guidance of HIFU synergistic treatment of tumors. Furthermore, PFH@CL/Fe 3 O 4 NPs could form microbubbles by acoustic droplet evaporation and promote efficiency of HIFU ablation under guidance of bimodal imaging. Conclusion:A bio-targeting nanoplatform with high stability and good physicochemical properties was constructed. The HIFU synergistic agent achieved early precision imaging of tumors and promoted therapeutic effect, monitored by US and MR bimodal imaging during the treatment process.

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Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Cited by 37 publications

References 55 publications

Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

Bacteria-Driven Tumor Microenvironment-Sensitive Nanoparticles Targeting Hypoxic Regions Enhances the Chemotherapy Outcome of Lung Cancer

Establishment of ultrasound-responsive SonoBacteriaBot for targeted drug delivery and controlled release

US/MR Bimodal Imaging-Guided Bio-Targeting Synergistic Agent for Tumor Therapy

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