Bacteria-derived outer membrane vesicles engineered with over-expressed pre-miRNA as delivery nanocarriers for cancer therapy

Cui, Chenyang; Guo, Tingting; Zhang, Shuai; Yang, Mingjun; Cheng, Jiaqi; Wang, Jiajia; Kang, Jie; Ma, Wenjie; Nian, Yuanru; Sun, Zhiyong; Weng, Haibo

doi:10.1016/j.nano.2022.102585

Cited by 9 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro studies using eukaryotic cells demonstrated that pre-miRNA incorporated inside OMVs could be delivered and processed to mature miRNAs using tRNA scaffolds ( Figure 5 ). In vivo characterization further showed the successful inhibition of the expression of target oncogenic CXCR4 using OMVtRNA-pre-miR-126 to suppress the growth of breast cancer cells [ 177 ]. The use of exosomes as delivery carriers for miRNA may be effective in overcoming in vivo miRNA degradation since exosomes can efficiently cross the biological carrier and sustain communication with target cells.…”

Section: Mirna Delivery Systemsmentioning

confidence: 99%

miRNA: A Promising Therapeutic Target in Cancer

Menon

Abd‐Aziz

Khalid

et al. 2022

IJMS

126

View full text Add to dashboard Cite

microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.

show abstract

Section: Mirna Delivery Systemsmentioning

confidence: 99%

miRNA: A Promising Therapeutic Target in Cancer

Menon

Abd‐Aziz

Khalid

et al. 2022

IJMS

126

View full text Add to dashboard Cite

show abstract

“…Limited clinical evidence has demonstrated a positive correlation between the abundance of plasma PA and the BMD/T score (Wang et al., 2022). PA significantly accumulates in bone marrow during the early stages of OP after ovariectomy, but such change is not observed in the late stage of OP following ovariectomy (Cui et al., 2023), indicating the potential consumption of PA during the progression of bone loss. However, it has been shown that PA acts as an inflammatory trigger by activating Toll‐like receptor 2 (TLR2) and increasing the expression of NACHT, LRR and PYD domains‐containing protein 3 (NALP3), which in turn induces the expression and release of IL‐1b (Snodgrass et al., 2013), ultimately leading to the apoptosis of osteoblasts (Cao et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

Grape seed extract prevents oestrogen deficiency‐induced bone loss by modulating the gut microbiota and metabolites

Lu,

Li,

Liu

et al. 2024

Microbial Biotechnology

View full text Add to dashboard Cite

Proanthocyanidin‐rich grape seed extract (GSE) has been shown to have the potential to protect bones, although the underlying mechanism remains unknown. The current study aims to explore GSE's preventive and therapeutic impact on bone loss induced by oestrogen deficiency and the underlying mechanism through the gut microbiota (GM) and metabolomic responses. In oestrogen‐deficient ovariectomized (OVX) mice, GSE ameliorated bone loss by inhibiting the expansion of bone marrow adipose tissue (BMAT), restoring BMAT lipolysis and promoting bone formation. GSE regulated OVX‐induced GM dysbiosis by reducing the abundance of opportunistic pathogenic bacteria, such as Alistipes, Turicibacter and Romboutsia, while elevating the abundance of beneficial bacteria, such as Bifidobacterium. The modified GM primarily impacted lipid and amino acid metabolism. Furthermore, the serum metabolites of GSE exhibited a significant enrichment in lipid metabolism. In summary, GSE shows potential as a functional food for preventing oestrogen deficiency‐induced bone loss by modulating GM and metabolite‐mediated lipid metabolism.

show abstract

“…In addition, the researchers designed a nanobody-functionalized nucleic acid nanogel for the targeted delivery of miRNAs to cells to treat tumors [ 133 , 134 , 135 ]. Recently, new studies have found that the use of outer membrane vesicles (OMVs) of Escherichia coli as a delivery system for miRNA transport in nanoscale spherical vesicles is promising in cancer therapy [ 136 ]. Moreover, using exosomes as miRNA delivery vehicles may effectively overcome miRNA degradation in vivo, which has also been shown to promote cancer cell apoptosis [ 137 ].…”

Section: Micrornas As Therapeutic Targets For Obesitymentioning

confidence: 99%

MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity

Gilani

et al. 2022

Biology

View full text Add to dashboard Cite

Obesity is a growing health problem worldwide, associated with an increased risk of multiple chronic diseases. The thermogenic activity of brown adipose tissue (BAT) correlates with leanness in adults. Understanding the mechanisms behind BAT activation and the process of white fat “browning” has important implications for developing new treatments to combat obesity. MicroRNAs (miRNAs) are small transcriptional regulators that control gene expression in various tissues, including adipose tissue. Recent studies show that miRNAs are involved in adipogenesis and adipose tissue thermogenesis. In this review, we discuss recent advances in the role of miRNAs in adipocyte thermogenesis and obesity. The potential for miRNA-based therapies for obesity and recommendations for future research are highlighted, which may help provide new targets for treating obesity and obesity-related diseases.

show abstract

Bacteria-derived outer membrane vesicles engineered with over-expressed pre-miRNA as delivery nanocarriers for cancer therapy

Cited by 9 publications

References 40 publications

miRNA: A Promising Therapeutic Target in Cancer

miRNA: A Promising Therapeutic Target in Cancer

Grape seed extract prevents oestrogen deficiency‐induced bone loss by modulating the gut microbiota and metabolites

MicroRNAs as Mediators of Adipose Thermogenesis and Potential Therapeutic Targets for Obesity

Contact Info

Product

Resources

About