Bacteria as vitamin suppliers to their host: a gut microbiota perspective

LeBlanc, Jean Guy; Milani, Christian; Giori, Graciela Savoy de; Sesma, Fernando; Sinderen, Douwe van; Ventura, Marco

doi:10.1016/j.copbio.2012.08.005

Cited by 1,099 publications

(698 citation statements)

References 64 publications

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“…For vitamin C, a defined mixed co‐culture process is recently established on a large scale, and even a direct fermentation route is about to bring a breakthrough. Furthermore, it is well known that gut microbiota, mainly anaerobic eubacteria and archaea, act as vitamin suppliers to their hosts (Le Blanc et al ., 2013); however, few of them have been studied sufficiently in this context. They could be a source of novel genes and for strain development for industrial vitamin and other growth and health factor production.…”

Section: Challenges and Future Developmentsmentioning

confidence: 99%

Microbial biotechnology for the synthesis of (pro)vitamins, biopigments and antioxidants: challenges and opportunities

Revuelta

Buey

Ledesma‐Amaro

et al. 2016

Microbial Biotechnology

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SummaryVitamins and related compounds, such as provitamins, biopigments and antioxidants, belong to those few chemicals that appeal in a positive way to most people. These terms sound synonymous to vitality, good health and mental strenght, even to the layman. Everyone of us needs his/her daily intake of (pro)vitamins and antioxidants, normally provided by a balanced and varied diet. However, current food habits or preferences, food availabilities, as well as food processing, preservation or cooking methodologies and technologies, do not always assure a sufficient balanced natural daily (pro)vitamin supply to a healthy individual, and even more so for a stressed or sick human being. Today, modern society is seldom confronted with the notorious avitaminoses of the past, well known to the Western World, but they do still occur frequently in overpopulated, war‐ridden, poverty‐ or famine‐struck regions on our globe, as well as for surprisingly large population groups in developed countries.

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Section: Challenges and Future Developmentsmentioning

confidence: 99%

Microbial biotechnology for the synthesis of (pro)vitamins, biopigments and antioxidants: challenges and opportunities

Revuelta

Buey

Ledesma‐Amaro

et al. 2016

Microbial Biotechnology

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“…The host takes up and utilizes an array of bacterial metabolites, including a major energy source in the form of short chain fatty acids, as well as folic acid and vitamins (60). LeBlanc and colleagues also propose that such bacterial metabolites interact with the mammalian epigenetic machinery, including histone modifications and DNA methylation, thereby influencing the host's chromatin state and active gene expression (60). As such, the effects of breastfeeding and the variations in its constituents modulate a complex array of physiological processes and systems.…”

Section: Breastfeeding: Modulation Of the Gut And Gut-brain Axismentioning

confidence: 99%

Breastfeeding and the gut-brain axis: is there a role for melatonin?

Anderson¹,

Vaillancourt²,

Maes

et al. 2017

Biomolecular Concepts

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The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a significant improvement in the contents of formula feed. In this article, the overlooked role of melatonin and the melatonergic pathways in breast milk and in the regulation of wider breast milk components are reviewed. There is a growing appreciation that the benefits of breastfeeding are mediated by its effects in the infant gut, with consequences for the development of the gut-brain axis and the immune system. The melatonergic pathways are intimately associated with highly researched processes in the gut, gut microbiome and gut-brain axis. As the melatonergic pathways are dependent on the levels of serotonin availability as a necessary precursor, decreased melatonin is linked to depression and depression-associated disorders. The association of breastfeeding and the gut-brain axis with a host of medical conditions may be mediated by their regulation of processes that modulate depression susceptibility. The biological underpinnings of depression include increased levels of pro-inflammatory cytokines, oxidative stress, kynurenine pathway activity and dysregulation of the hypothalamic-pituitary adrenal axis, all of which can decrease melatonergic pathway activity. The inclusion of the melatonergic pathways in the biological interactions of breast milk and gut development has significant theoretical and treatment implications, as well as being important to the prevention of a host of infant-, child-and adult-onset medical conditions.

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“…These techniques can be used for in-cell NMR (29)(30)(31) or fluorescence (32-34) studies of already translated and folded proteins. Studying cotranslational folding in vivo is even more difficult, as the ribosome itself contains more than 50 proteins in E. coli, a number that increases up to 80 in eukaryotes (35). In addition, chaperones such as Trigger factor and DnaK, but also enzymes such as PDF, MAP and other modifying enzymes interact (transiently) with the nascent chain (20).…”

Section: Techniques To Study Protein Folding In Vivomentioning

confidence: 99%

“…Off-pathway intermediate formation is also characteristic for the folding of CheY-like proteins, which share the flavodoxin-like fold (33,34). A MG that has been extensively studied is the off-pathway MG (MG off ) of the 179-residue flavodoxin from A. vinelandii (32, [35][36][37][38][39][40][41][42][43].…”

Section: W74mentioning

confidence: 99%

“…The flavodoxin-like fold is an ancestral fold (30) and is archetypal for the class of αβα sandwiches. It has been well established that proteins with a flavodoxin-like architecture fold in vitro through involvement of an off-pathway intermediate (11,(31)(32)(33)(34)(35)(36)(37). Upon folding, the large majority of unfolded flavodoxin molecules temporarily misfold.…”

Section: Introductionmentioning

confidence: 99%

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The ribosome regulates flavodoxin folding

Houwman¹

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Bacteria as vitamin suppliers to their host: a gut microbiota perspective

Cited by 1,099 publications

References 64 publications

Microbial biotechnology for the synthesis of (pro)vitamins, biopigments and antioxidants: challenges and opportunities

Microbial biotechnology for the synthesis of (pro)vitamins, biopigments and antioxidants: challenges and opportunities

Breastfeeding and the gut-brain axis: is there a role for melatonin?

The ribosome regulates flavodoxin folding

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