Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease

Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China

“…It can cause meningitis in ducklings and septicemia in pigeons, goslings and turkey poults, leading to high mortality in these poultries [5,6,7,8]. In humans, it is increasingly recognized as a cause of infant meningitis and bacteremia [9,10,11,12], and 58.7% of mortality rate has been observed with one-year neonates relating to this subspecies [13]. In adults, it is linked to a wide spectrum of diseases, including meningitis [14], endocarditis [15,16,17], splenic abscess [18], biliary and urinary tract infection [15,19,20,21], as well as gastric, pancreatic, hepatobiliary and colorectal cancers [16,22].…”

Association of bacteremias of Streptococcus gallolyticus with the development of colorectal cancer in people 65 years of age

“…Unfortunately, this association has been underestimated in the medical community, and the nomenclature trap in the literature and laboratories makes bacterial identification difficult. However, through the observation and adequate and timely monitoring of the patient, due to the possible pathogenic role of Streptococcus gallolyticus in colorectal cancer, it is possible to perform an early diagnosis and potentially curative treatment that saves the patient's life 4,5,[9][10][11][12][13][14][15][22][23][24] Therefore, the detection of this bacterial group in blood cultures or serum levels of elevated IgG antibodies against Streptococcus gallolyticus indicates the need for an evaluation to establish the origin of bacteremia and the presence of possible complications. 3,18,23,24 The present analysis describes a series of case reports that represent the evidence that exists between bacteraemia due to S. gallolyticus and its association with the presence of colorectal cancer and colorectal adenomas in patients with an average age of 65 years.…”

“…of colon through a report in which he made a complete evaluation of 15 patients with bacteraemia due to S. gallolyticus. 1,6,8,10,[13][14][15] With the report of Klein, a barrier that prevented directly related to Streptococcus was overcome gallolyticus with colorectal cancer, since through this study it was possible to formally establish the association that S. gallolyticus bacteremia has with the concomitant development of colorectal cancer, malignant or pre-malignant colorectal neoplasms and even with gastrointestinal neoplasms. This additionally suggests with certainty the performance of colonoscopy exams in infected patients, since the performance of colonoscopy after S. gallolyticus bacteremia could allow the detection of colorectal neoplasms in early or precancerous stages in affected patients, and thus, its clinical evolution would be beneficial for the reduction of morbidity and general mortality.…”

“…[1][2][3][4][5][6][7][8][9][10][11] Multiple factors can lead to the transformation of healthy intestinal mucosa to cancer, both inheritance and environmental factors such as personal and/or family history of colorectal cancer and adenomatous polyps, hereditary syndromes, diet (fat consumption) and obesity, physical inactivity, alcoholism, smoking, inflammatory bowel disease (such as ulcerative colitis) and pot agents Essentially infectious. [10][11][12][13] Specifically in patients with bacteremia due to S. gallolyticus, according to statistics, the most associated factors are obesity, alcohol abuse, smoking, diabetes mellitus, gastrointestinal surgery and cancer present or ancient. 14 S. gallolyticus was first associated with colorectal cancer and infectious endocarditis in 1951 by McCoy and Mason, however it was not until 1977 that S. gallolyticus was recognized by Robert Klein as the pathogen specifically related to the concomitant development of cancer.…”

Auxiliary antitumor effects of fungal proteins from Hericium erinaceus by target on the gut microbiota

“…In addition, research confirmed that Streptococcus , Enterococcus , Bacteroides fragilis , Fusobacterium , and Helicobacter hepaticus were associated with colorectal, breast, prostate, and liver cancer (Biragyn & Ferrucci, 2018). Certain strains of the Streptococcus bovis/equinus complex are consumed by millions of people daily and thus may be safe (Marmolin et al., 2016). However, 25% to 80% of people with S. bovis/gallolyticus bacteremia have concomitant colorectal tumors, and S. bovis/gallolyticus seropositivity is a candidate practical marker for the early prediction of an underlying bowel lesion in high‐risk populations (Chirouze et al., 2013).…”