Bacteremia in Charleston County, South Carolina

Filice, Gregory; Etta, Linda L. Van; Darby, Charles P.; Fraser, David W.

doi:10.1093/oxfordjournals.aje.a114206

Cited by 39 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, case-fatality rates in studies of IPD from other centres, both inside and outside Sweden, have varied considerably, from ,3 to 25%, or higher [10,14,[20][21][22][23][24][25][26][27][28][29]. These varying case-fatality rates are likely to be due to differences between study populations concerning demographics, underlying health characteristics or severity of illness on admission to hospital [12,13].…”

Section: Discussionmentioning

confidence: 99%

Prognostic score systems and community-acquired bacteraemic pneumococcal pneumonia

Spindler

Örtqvist²

2006

European Respiratory Journal

View full text Add to dashboard Cite

The aim of this study was to evaluate the accuracy of three score systems: the pneumonia severity index (PSI); CURB-65 (confusion; urea .7 mM; respiratory rate o30 breaths?min -1 ; blood pressure ,90 mmHg systolic or f60 mmHg diastolic; aged o65 yrs old); and modified American Thoracic Society rule for predicting intensive care unit (ICU) need and mortality due to bacteraemic pneumococcal pneumonia. All adult patients (n5114) with invasive pneumococcal pneumonia at the Karolinska University Hospital, Sweden, 1999-2000, were included in the study. Severity scores were calculated and the independent prognostic importance of different variables was analysed by multiple regression analyses.PSI oIV, CURB-65 o2, and the presence of one major or more than one minor risk factor in mATS all had a high sensitivity, but somewhat lower specificity for predicting death and ICU need. The death rate was 12% (13 out of 114). Severity score and treatment in departments other than the Dept of Infectious Diseases were the only factors independently correlated to death. Patients treated in other departments more often had severe underlying illnesses and were more severely ill on admission. However, a significant difference in death rates remained after adjustment for severity between the two groups.In conclusion, all score systems were useful for predicting the need for intensive care unit treatment and death due to bacteremic pneumococcal pneumonia. The pneumonia severity index was the most sensitive, but CURB-65 was easier to use.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic score systems and community-acquired bacteraemic pneumococcal pneumonia

Spindler

Örtqvist²

2006

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…In the United States, African American populations have higher rates of SAB (61) and MRSA-B (74,95,143) than Caucasian patients. In 2005, in a U.S. population-based surveillance study, predominantly of health care-associated MRSA bacteremic episodes (66%; 5,813/8,792), the annual invasive MRSA infection incidence rate for Caucasians was 27.7/100,000 population (95% CI, 21.9 to 32.4), compared to 66.5/100,000 (95% CI, 43.5 to 63.1) for African Americans (143).…”

Section: Ethnicitymentioning

confidence: 99%

Predictors of Mortality in Staphylococcus aureus Bacteremia

et al. 2012

View full text Add to dashboard Cite

SUMMARY Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these patients will die from SAB. Comparatively, this accounts for a greater number of deaths than for AIDS, tuberculosis, and viral hepatitis combined. Multiple factors influence outcomes for SAB patients. The most consistent predictor of mortality is age, with older patients being twice as likely to die. Except for the presence of comorbidities, the impacts of other host factors, including gender, ethnicity, socioeconomic status, and immune status, are unclear. Pathogen-host interactions, especially the presence of shock and the source of SAB, are strong predictors of outcomes. Although antibiotic resistance may be associated with increased mortality, questions remain as to whether this reflects pathogen-specific factors or poorer responses to antibiotic therapy, namely, vancomycin. Optimal management relies on starting appropriate antibiotics in a timely fashion, resulting in improved outcomes for certain patient subgroups. The roles of surgery and infectious disease consultations require further study. Although the rate of mortality from SAB is declining, it remains high. Future international collaborative studies are required to tease out the relative contributions of various factors to mortality, which would enable the optimization of SAB management and patient outcomes.

show abstract

“…Escherichia coli is the most common cause of BSI reported in overall population-based studies (1)(2)(3)(4)(5)(6)(7)(8)(9). However, few population-based studies have specifically focused on E. coli BSI (78-81).…”

Section: Specific Etiologiesmentioning

confidence: 99%

“…loodstream infection (BSI) is a major cause of infectious disease morbidity and mortality worldwide (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Due to a number of determinants, not limited to changing population de-mographics, shifts in health care delivery models, and increasing globalization, the epidemiology of community-onset BSI has been changing in recent decades.…”

mentioning

confidence: 99%

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

2014

View full text Add to dashboard Cite

SUMMARY Bloodstream infection (BSI) is a major cause of infectious disease morbidity and mortality worldwide. While a positive blood culture is mandatory for establishment of the presence of a BSI, there are a number of determinants that must be considered for establishment of this entity. Community-onset BSIs are those that occur in outpatients or are first identified <48 h after admission to hospital, and they may be subclassified further as health care associated, when they occur in patients with significant prior health care exposure, or community associated, in other cases. The most common causes of community-onset BSI include Escherichia coli , Staphylococcus aureus , and Streptococcus pneumoniae . Antimicrobial-resistant organisms, including methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase/metallo-β-lactamase/carbapenemase-producing Enterobacteriaceae , have emerged as important etiologies of community-onset BSI.

show abstract

Bacteremia in Charleston County, South Carolina

Cited by 39 publications

References 0 publications

Prognostic score systems and community-acquired bacteraemic pneumococcal pneumonia

Prognostic score systems and community-acquired bacteraemic pneumococcal pneumonia

Predictors of Mortality in Staphylococcus aureus Bacteremia

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

Contact Info

Product

Resources

About